The QUASAR reproducibility study, Part II : Results from a multi-center Arterial Spin Labeling test-retest study
(2010) In NeuroImage 49(1). p.13-104- Abstract
Arterial Spin Labeling (ASL) is a method to measure perfusion using magnetically labeled blood water as an endogenous tracer. Being fully non-invasive, this technique is attractive for longitudinal studies of cerebral blood flow in healthy and diseased individuals, or as a surrogate marker of metabolism. So far, ASL has been restricted mostly to specialist centers due to a generally low SNR of the method and potential issues with user-dependent analysis needed to obtain quantitative measurement of cerebral blood flow (CBF). Here, we evaluated a particular implementation of ASL (called Quantitative STAR labeling of Arterial Regions or QUASAR), a method providing user independent quantification of CBF in a large test-retest study across... (More)
Arterial Spin Labeling (ASL) is a method to measure perfusion using magnetically labeled blood water as an endogenous tracer. Being fully non-invasive, this technique is attractive for longitudinal studies of cerebral blood flow in healthy and diseased individuals, or as a surrogate marker of metabolism. So far, ASL has been restricted mostly to specialist centers due to a generally low SNR of the method and potential issues with user-dependent analysis needed to obtain quantitative measurement of cerebral blood flow (CBF). Here, we evaluated a particular implementation of ASL (called Quantitative STAR labeling of Arterial Regions or QUASAR), a method providing user independent quantification of CBF in a large test-retest study across sites from around the world, dubbed "The QUASAR reproducibility study". Altogether, 28 sites located in Asia, Europe and North America participated and a total of 284 healthy volunteers were scanned. Minimal operator dependence was assured by using an automatic planning tool and its accuracy and potential usefulness in multi-center trials was evaluated as well. Accurate repositioning between sessions was achieved with the automatic planning tool showing mean displacements of 1.87+/-0.95 mm and rotations of 1.56+/-0.66 degrees . Mean gray matter CBF was 47.4+/-7.5 [ml/100 g/min] with a between-subject standard variation SD(b)=5.5 [ml/100 g/min] and a within-subject standard deviation SD(w)=4.7 [ml/100 g/min]. The corresponding repeatability was 13.0 [ml/100 g/min] and was found to be within the range of previous studies.
(Less)
- author
- Petersen, Esben Thade ; Mouridsen, Kim and Golay, Xavier
- author collaboration
- publishing date
- 2010-01-01
- type
- Contribution to journal
- publication status
- published
- keywords
- Adolescent, Adult, Aged, Blood Volume, Brain Mapping, Cerebral Arteries, Cerebrovascular Circulation, Female, Humans, Male, Middle Aged, Reproducibility of Results, Software, Spin Labels, Young Adult
- in
- NeuroImage
- volume
- 49
- issue
- 1
- pages
- 10 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:19660557
- scopus:70349966233
- ISSN
- 1095-9572
- DOI
- 10.1016/j.neuroimage.2009.07.068
- project
- MRI brain perfusion quantification at 3 tesla using arterial spin labeling
- language
- English
- LU publication?
- no
- id
- 02636649-dbda-41a0-b39c-fb8bea001b99
- date added to LUP
- 2016-09-01 09:29:43
- date last changed
- 2024-04-05 05:35:53
@article{02636649-dbda-41a0-b39c-fb8bea001b99,
abstract = {{<p>Arterial Spin Labeling (ASL) is a method to measure perfusion using magnetically labeled blood water as an endogenous tracer. Being fully non-invasive, this technique is attractive for longitudinal studies of cerebral blood flow in healthy and diseased individuals, or as a surrogate marker of metabolism. So far, ASL has been restricted mostly to specialist centers due to a generally low SNR of the method and potential issues with user-dependent analysis needed to obtain quantitative measurement of cerebral blood flow (CBF). Here, we evaluated a particular implementation of ASL (called Quantitative STAR labeling of Arterial Regions or QUASAR), a method providing user independent quantification of CBF in a large test-retest study across sites from around the world, dubbed "The QUASAR reproducibility study". Altogether, 28 sites located in Asia, Europe and North America participated and a total of 284 healthy volunteers were scanned. Minimal operator dependence was assured by using an automatic planning tool and its accuracy and potential usefulness in multi-center trials was evaluated as well. Accurate repositioning between sessions was achieved with the automatic planning tool showing mean displacements of 1.87+/-0.95 mm and rotations of 1.56+/-0.66 degrees . Mean gray matter CBF was 47.4+/-7.5 [ml/100 g/min] with a between-subject standard variation SD(b)=5.5 [ml/100 g/min] and a within-subject standard deviation SD(w)=4.7 [ml/100 g/min]. The corresponding repeatability was 13.0 [ml/100 g/min] and was found to be within the range of previous studies.</p>}},
author = {{Petersen, Esben Thade and Mouridsen, Kim and Golay, Xavier}},
issn = {{1095-9572}},
keywords = {{Adolescent; Adult; Aged; Blood Volume; Brain Mapping; Cerebral Arteries; Cerebrovascular Circulation; Female; Humans; Male; Middle Aged; Reproducibility of Results; Software; Spin Labels; Young Adult}},
language = {{eng}},
month = {{01}},
number = {{1}},
pages = {{13--104}},
publisher = {{Elsevier}},
series = {{NeuroImage}},
title = {{The QUASAR reproducibility study, Part II : Results from a multi-center Arterial Spin Labeling test-retest study}},
url = {{http://dx.doi.org/10.1016/j.neuroimage.2009.07.068}},
doi = {{10.1016/j.neuroimage.2009.07.068}},
volume = {{49}},
year = {{2010}},
}