Continuous drug delivery aiming continuous dopaminergic stimulation in Parkinson's disease
(2018) In Journal of Parkinson's Disease 8(s1). p.65-72- Abstract
Continuous dopaminergic stimulation in Parkinson's disease (PD) has several advantages over pulsatile, noncontinuous, stimulation. These therapies currently consist of pump-based and transcutaneous therapies and are based on a more constant delivery of the dopaminergic drug resulting in continuous dopaminergic stimulation and a more stable treatment effect. Several clinical and experimental observations have shown that continuous stimulation of dopaminergic receptors induces fewer complications, such as dyskinesia, compared to pulsatile stimulation. Currently available nonoral pharmacological continuous therapies in PD include the transdermal Rotigotine (RTG) patch, infusion therapies with Apomorphine and Intrajejunal Levodopa (IJLI)... (More)
Continuous dopaminergic stimulation in Parkinson's disease (PD) has several advantages over pulsatile, noncontinuous, stimulation. These therapies currently consist of pump-based and transcutaneous therapies and are based on a more constant delivery of the dopaminergic drug resulting in continuous dopaminergic stimulation and a more stable treatment effect. Several clinical and experimental observations have shown that continuous stimulation of dopaminergic receptors induces fewer complications, such as dyskinesia, compared to pulsatile stimulation. Currently available nonoral pharmacological continuous therapies in PD include the transdermal Rotigotine (RTG) patch, infusion therapies with Apomorphine and Intrajejunal Levodopa (IJLI) and the Rivastigmine patch. Here we aim to provide a concise review of these current therapies and discuss ongoing and future developments of continuous non-oral pharmacological dopaminergic therapies in PD.
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- author
- Van Wamelen, Daniel J. ; Grigoriou, Sotirios LU ; Chaudhuri, K. Ray and Odin, Per LU
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Apomorphine, Infusion pumps, Parkinson's disease, Rivastigmine, Rotigotine
- in
- Journal of Parkinson's Disease
- volume
- 8
- issue
- s1
- pages
- 65 - 72
- publisher
- IOS Press
- external identifiers
-
- pmid:30584160
- scopus:85058850953
- ISSN
- 1877-7171
- DOI
- 10.3233/JPD-181476
- language
- English
- LU publication?
- yes
- id
- 0d0bdaa1-6997-44a1-bcde-32e31913e027
- date added to LUP
- 2019-01-11 09:14:07
- date last changed
- 2024-03-18 22:49:59
@article{0d0bdaa1-6997-44a1-bcde-32e31913e027, abstract = {{<p>Continuous dopaminergic stimulation in Parkinson's disease (PD) has several advantages over pulsatile, noncontinuous, stimulation. These therapies currently consist of pump-based and transcutaneous therapies and are based on a more constant delivery of the dopaminergic drug resulting in continuous dopaminergic stimulation and a more stable treatment effect. Several clinical and experimental observations have shown that continuous stimulation of dopaminergic receptors induces fewer complications, such as dyskinesia, compared to pulsatile stimulation. Currently available nonoral pharmacological continuous therapies in PD include the transdermal Rotigotine (RTG) patch, infusion therapies with Apomorphine and Intrajejunal Levodopa (IJLI) and the Rivastigmine patch. Here we aim to provide a concise review of these current therapies and discuss ongoing and future developments of continuous non-oral pharmacological dopaminergic therapies in PD.</p>}}, author = {{Van Wamelen, Daniel J. and Grigoriou, Sotirios and Chaudhuri, K. Ray and Odin, Per}}, issn = {{1877-7171}}, keywords = {{Apomorphine; Infusion pumps; Parkinson's disease; Rivastigmine; Rotigotine}}, language = {{eng}}, number = {{s1}}, pages = {{65--72}}, publisher = {{IOS Press}}, series = {{Journal of Parkinson's Disease}}, title = {{Continuous drug delivery aiming continuous dopaminergic stimulation in Parkinson's disease}}, url = {{http://dx.doi.org/10.3233/JPD-181476}}, doi = {{10.3233/JPD-181476}}, volume = {{8}}, year = {{2018}}, }