High levels of HIF-2alpha highlight an immature neural crest-like neuroblastoma cell cohort located in a perivascular niche.
(2008) In Journal of Pathology 214(4). p.482-488- Abstract
- High HIF-2alpha protein levels in the sympathetic nervous system-derived childhood tumour neuroblastoma as well as immature phenotype correlate to unfavourable outcome. Here we show that a small subset of perivascularly located, strongly HIF-2alpha-positive tumour cells (MYCN amplified) lacks expression of differentiation markers, but expresses neural crest and early sympathetic progenitor marker genes such as Notch-1, HES-1, c-Kit, dHAND, and vimentin. HIF-2alpha- and CD68-positive tumour-associated macrophages were frequently found close to the immature and HIF-2alpha-positive neuroblastoma cells and as VEGF levels are high in the perivascular niche, we hypothesize that neuroblastoma neural crest-like cells and macrophages cooperate to... (More)
- High HIF-2alpha protein levels in the sympathetic nervous system-derived childhood tumour neuroblastoma as well as immature phenotype correlate to unfavourable outcome. Here we show that a small subset of perivascularly located, strongly HIF-2alpha-positive tumour cells (MYCN amplified) lacks expression of differentiation markers, but expresses neural crest and early sympathetic progenitor marker genes such as Notch-1, HES-1, c-Kit, dHAND, and vimentin. HIF-2alpha- and CD68-positive tumour-associated macrophages were frequently found close to the immature and HIF-2alpha-positive neuroblastoma cells and as VEGF levels are high in the perivascular niche, we hypothesize that neuroblastoma neural crest-like cells and macrophages cooperate to facilitate angiogenesis and thereby contribute to the aggressive neuroblastoma phenotype. Copyright (c) 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1021450
- author
- Pietras, Alexander LU ; Gisselsson Nord, David LU ; Øra, Ingrid LU ; Noguera, R ; Beckman, Siv LU ; Navarro, S and Påhlman, Sven LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Pathology
- volume
- 214
- issue
- 4
- pages
- 482 - 488
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:18189331
- wos:000253732200010
- scopus:40349088993
- pmid:18189331
- ISSN
- 0022-3417
- DOI
- 10.1002/path.2304
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Molecular Medicine (013031200), Division of Clinical Genetics (013022003), Paediatrics (Lund) (013002000)
- id
- 852ba686-f424-46a0-8d2f-e74f5a0be64a (old id 1021450)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18189331?dopt=Abstract
- date added to LUP
- 2016-04-01 12:04:43
- date last changed
- 2022-01-26 22:29:37
@article{852ba686-f424-46a0-8d2f-e74f5a0be64a,
abstract = {{High HIF-2alpha protein levels in the sympathetic nervous system-derived childhood tumour neuroblastoma as well as immature phenotype correlate to unfavourable outcome. Here we show that a small subset of perivascularly located, strongly HIF-2alpha-positive tumour cells (MYCN amplified) lacks expression of differentiation markers, but expresses neural crest and early sympathetic progenitor marker genes such as Notch-1, HES-1, c-Kit, dHAND, and vimentin. HIF-2alpha- and CD68-positive tumour-associated macrophages were frequently found close to the immature and HIF-2alpha-positive neuroblastoma cells and as VEGF levels are high in the perivascular niche, we hypothesize that neuroblastoma neural crest-like cells and macrophages cooperate to facilitate angiogenesis and thereby contribute to the aggressive neuroblastoma phenotype. Copyright (c) 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.}},
author = {{Pietras, Alexander and Gisselsson Nord, David and Øra, Ingrid and Noguera, R and Beckman, Siv and Navarro, S and Påhlman, Sven}},
issn = {{0022-3417}},
language = {{eng}},
number = {{4}},
pages = {{482--488}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Journal of Pathology}},
title = {{High levels of HIF-2alpha highlight an immature neural crest-like neuroblastoma cell cohort located in a perivascular niche.}},
url = {{http://dx.doi.org/10.1002/path.2304}},
doi = {{10.1002/path.2304}},
volume = {{214}},
year = {{2008}},
}