Intracranial haemorrhage in haemophilia A and B.
Ljung, Rolf LU
(2008)
In British Journal of Haematology
140(4).
p.378-384
- Abstract
- In countries with a good standard of health care, intracranial haemorrhage (ICH) during the neonatal period affects 3.5-4.0% of all haemophilia boys, which is considerably (40-80 times) higher than expected in the normal population. ICHs are also frequent after the neonatal period, affecting 3-10% of the haemophilia population who are mainly treated on demand. The risk is higher in inhibitor patients. Spontaneous haemorrhage is reported more frequently than trauma-induced haemorrhage in most studies. The prevalence of ICH in patients treated with a prophylactic regimen is not known. Although more frequent in younger patients, a substantial proportion of ICH occur in adults, suggesting that general risk factors because of age, such as... (More)
- In countries with a good standard of health care, intracranial haemorrhage (ICH) during the neonatal period affects 3.5-4.0% of all haemophilia boys, which is considerably (40-80 times) higher than expected in the normal population. ICHs are also frequent after the neonatal period, affecting 3-10% of the haemophilia population who are mainly treated on demand. The risk is higher in inhibitor patients. Spontaneous haemorrhage is reported more frequently than trauma-induced haemorrhage in most studies. The prevalence of ICH in patients treated with a prophylactic regimen is not known. Although more frequent in younger patients, a substantial proportion of ICH occur in adults, suggesting that general risk factors because of age, such as hypertension, are increasingly important as the haemophiliac gets older. Some studies have reported a substantial proportion of ICH affecting patients with milder forms of haemophilia. The risk of ICH has to be considered when discussing treatment strategies for haemophilia patients. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1035254
- author
- Ljung, Rolf
LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- British Journal of Haematology
- volume
- 140
- issue
- 4
- pages
- 378 - 384
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:18081890
- wos:000252556400002
- scopus:38349191638
- ISSN
- 0007-1048
- DOI
- 10.1111/j.1365-2141.2007.06949.x
- language
- English
- LU publication?
- yes
- id
- e9bab411-3033-4ead-bb32-8109649703f8 (old id 1035254)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18081890?dopt=Abstract
- date added to LUP
- 2016-04-04 08:16:04
- date last changed
- 2022-08-08 07:09:49
@article{e9bab411-3033-4ead-bb32-8109649703f8,
abstract = {{In countries with a good standard of health care, intracranial haemorrhage (ICH) during the neonatal period affects 3.5-4.0% of all haemophilia boys, which is considerably (40-80 times) higher than expected in the normal population. ICHs are also frequent after the neonatal period, affecting 3-10% of the haemophilia population who are mainly treated on demand. The risk is higher in inhibitor patients. Spontaneous haemorrhage is reported more frequently than trauma-induced haemorrhage in most studies. The prevalence of ICH in patients treated with a prophylactic regimen is not known. Although more frequent in younger patients, a substantial proportion of ICH occur in adults, suggesting that general risk factors because of age, such as hypertension, are increasingly important as the haemophiliac gets older. Some studies have reported a substantial proportion of ICH affecting patients with milder forms of haemophilia. The risk of ICH has to be considered when discussing treatment strategies for haemophilia patients.}},
author = {{Ljung, Rolf}},
issn = {{0007-1048}},
language = {{eng}},
number = {{4}},
pages = {{378--384}},
publisher = {{Wiley-Blackwell}},
series = {{British Journal of Haematology}},
title = {{Intracranial haemorrhage in haemophilia A and B.}},
url = {{http://dx.doi.org/10.1111/j.1365-2141.2007.06949.x}},
doi = {{10.1111/j.1365-2141.2007.06949.x}},
volume = {{140}},
year = {{2008}},
}