A review of pioglitazone HCL and glimepiride in the treatment of type 2 diabetes.
(2007) In Vascular Health and Risk Management 3(5). p.721-731- Abstract
- Type 2 diabetes (T2D) is a progressive disorder with a consistent and steady increase in glycosylated hemoglobin (HbA1c) over time associated with enhanced risk of micro- and macrovascular complications and a substantial reduction in life expectancy. There are three major pathophysiologic abnormalities associated with T2D: impaired insulin secretion, excessive hepatic glucose output, and insulin resistance in skeletal muscle, liver, and adipose tissue. These defects have been treated in clinical praxis by use of oral insulin secretagogues (sulfonylureas/ glinides) or insulin, biguanides, and thiazolidinediones (TZDs) respectively. Pioglitazone HCL is an insulin sensitizer in the TZD family and glimepiride is an insulin secretagogue in the... (More)
- Type 2 diabetes (T2D) is a progressive disorder with a consistent and steady increase in glycosylated hemoglobin (HbA1c) over time associated with enhanced risk of micro- and macrovascular complications and a substantial reduction in life expectancy. There are three major pathophysiologic abnormalities associated with T2D: impaired insulin secretion, excessive hepatic glucose output, and insulin resistance in skeletal muscle, liver, and adipose tissue. These defects have been treated in clinical praxis by use of oral insulin secretagogues (sulfonylureas/ glinides) or insulin, biguanides, and thiazolidinediones (TZDs) respectively. Pioglitazone HCL is an insulin sensitizer in the TZD family and glimepiride is an insulin secretagogue in the SU family. This article reviews mechanisms of action and clinical data behind the use of these two commonly used oral hypoglycemic agents with documented efficacy and good safety profile of once-daily administration, alone or in combination with insulin or metformin, in the management of T2D in terms of glycemic and non-glycemic effects, tolerability and side effects, and impact on vascular health. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1035310
- author
- Dorkhan, Mozhgan LU and Frid, Anders LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Sulfonylurea Compounds: therapeutic use, Thiazolidinediones: therapeutic use, Diabetes Mellitus, Sulfonylurea Compounds: adverse effects, Type 2: drug therapy, Type 2: blood, Blood Glucose: metabolism, Thiazolidinediones: adverse effects
- in
- Vascular Health and Risk Management
- volume
- 3
- issue
- 5
- pages
- 721 - 731
- publisher
- Dove Medical Press Ltd.
- external identifiers
-
- pmid:18078023
- scopus:36148960037
- ISSN
- 1178-2048
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Diabetes and Endocrinology (013241530), Pediatrics/Urology/Gynecology/Endocrinology (013240400)
- id
- 94a58947-6dc1-4842-8462-35148a04db24 (old id 1035310)
- alternative location
- http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2291316
- date added to LUP
- 2016-04-01 12:02:28
- date last changed
- 2024-01-08 06:04:41
@article{94a58947-6dc1-4842-8462-35148a04db24,
abstract = {{Type 2 diabetes (T2D) is a progressive disorder with a consistent and steady increase in glycosylated hemoglobin (HbA1c) over time associated with enhanced risk of micro- and macrovascular complications and a substantial reduction in life expectancy. There are three major pathophysiologic abnormalities associated with T2D: impaired insulin secretion, excessive hepatic glucose output, and insulin resistance in skeletal muscle, liver, and adipose tissue. These defects have been treated in clinical praxis by use of oral insulin secretagogues (sulfonylureas/ glinides) or insulin, biguanides, and thiazolidinediones (TZDs) respectively. Pioglitazone HCL is an insulin sensitizer in the TZD family and glimepiride is an insulin secretagogue in the SU family. This article reviews mechanisms of action and clinical data behind the use of these two commonly used oral hypoglycemic agents with documented efficacy and good safety profile of once-daily administration, alone or in combination with insulin or metformin, in the management of T2D in terms of glycemic and non-glycemic effects, tolerability and side effects, and impact on vascular health.}},
author = {{Dorkhan, Mozhgan and Frid, Anders}},
issn = {{1178-2048}},
keywords = {{Sulfonylurea Compounds: therapeutic use; Thiazolidinediones: therapeutic use; Diabetes Mellitus; Sulfonylurea Compounds: adverse effects; Type 2: drug therapy; Type 2: blood; Blood Glucose: metabolism; Thiazolidinediones: adverse effects}},
language = {{eng}},
number = {{5}},
pages = {{721--731}},
publisher = {{Dove Medical Press Ltd.}},
series = {{Vascular Health and Risk Management}},
title = {{A review of pioglitazone HCL and glimepiride in the treatment of type 2 diabetes.}},
url = {{http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2291316}},
volume = {{3}},
year = {{2007}},
}