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Immigrants from the Middle-East have a different form of Type 2 diabetes compared with Swedish patients.

Glans, Forouzan LU ; Elgzyri, Targ LU ; Shaat, Nael LU orcid ; Lindholm, Eero LU ; Apelqvist, Jan LU and Groop, Leif LU (2008) In Diabetic Medicine: A journal of the British Diabetic Association 25(3). p.303-307
Abstract
AIMS: To compare the clinical characteristics of Type 2 diabetes (T2DM) between immigrants from the Middle-East and Swedish patients. METHODS: The study group included 450 consecutive patients with T2DM, 379 Swedish-born aged 61 +/- 12 years and 71 patients originally from the Middle-East aged 50 +/- 11 years from the diabetes clinic of Malmo University Hospital. RESULTS: Onset of diabetes had occurred 12 years earlier in the Middle-East immigrants compared with the Swedish-born patients (43 +/- 10 vs. 55 +/- 12 years, P < 0.001). Immigrants had lower fasting serum C-peptide [0.7 (0.1-2.6) vs. 0.9 (0.1-4.0) nmol/l, P = 0.013], lower homeostasis model assessment (HOMA)-beta[1.7 (0.1-9.1) vs. 2.7 (0.1-59.0), P = 0.010], lower HOMA-IR [0.4... (More)
AIMS: To compare the clinical characteristics of Type 2 diabetes (T2DM) between immigrants from the Middle-East and Swedish patients. METHODS: The study group included 450 consecutive patients with T2DM, 379 Swedish-born aged 61 +/- 12 years and 71 patients originally from the Middle-East aged 50 +/- 11 years from the diabetes clinic of Malmo University Hospital. RESULTS: Onset of diabetes had occurred 12 years earlier in the Middle-East immigrants compared with the Swedish-born patients (43 +/- 10 vs. 55 +/- 12 years, P < 0.001). Immigrants had lower fasting serum C-peptide [0.7 (0.1-2.6) vs. 0.9 (0.1-4.0) nmol/l, P = 0.013], lower homeostasis model assessment (HOMA)-beta[1.7 (0.1-9.1) vs. 2.7 (0.1-59.0), P = 0.010], lower HOMA-IR [0.4 (0.02-1.19) vs. 0.4 (0.01-2.8), P = 0.005] than the Swedish group. A first-degree family history of diabetes was reported in 61% of immigrants, compared with 47% of Swedish-born (P = 0.022). CONCLUSIONS: Immigrants from the Middle-East have an earlier onset, stronger family history and more rapid decline of pancreatic B-cell function than Swedish patients, suggesting that they have a different form of T2DM compared with Swedish patients. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetic Medicine: A journal of the British Diabetic Association
volume
25
issue
3
pages
303 - 307
publisher
Wiley-Blackwell
external identifiers
  • pmid:18307458
  • wos:000253609300009
  • scopus:40049088818
ISSN
1464-5491
DOI
10.1111/j.1464-5491.2007.02366.x
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pediatrics/Urology/Gynecology/Endocrinology (013240400), Diabetes and Endocrinology (013241530)
id
879baa84-5280-4c59-a94d-f7909f0cf52f (old id 1052992)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18307458?dopt=Abstract
date added to LUP
2016-04-04 09:18:13
date last changed
2024-02-11 09:22:52
@article{879baa84-5280-4c59-a94d-f7909f0cf52f,
  abstract     = {{AIMS: To compare the clinical characteristics of Type 2 diabetes (T2DM) between immigrants from the Middle-East and Swedish patients. METHODS: The study group included 450 consecutive patients with T2DM, 379 Swedish-born aged 61 +/- 12 years and 71 patients originally from the Middle-East aged 50 +/- 11 years from the diabetes clinic of Malmo University Hospital. RESULTS: Onset of diabetes had occurred 12 years earlier in the Middle-East immigrants compared with the Swedish-born patients (43 +/- 10 vs. 55 +/- 12 years, P &lt; 0.001). Immigrants had lower fasting serum C-peptide [0.7 (0.1-2.6) vs. 0.9 (0.1-4.0) nmol/l, P = 0.013], lower homeostasis model assessment (HOMA)-beta[1.7 (0.1-9.1) vs. 2.7 (0.1-59.0), P = 0.010], lower HOMA-IR [0.4 (0.02-1.19) vs. 0.4 (0.01-2.8), P = 0.005] than the Swedish group. A first-degree family history of diabetes was reported in 61% of immigrants, compared with 47% of Swedish-born (P = 0.022). CONCLUSIONS: Immigrants from the Middle-East have an earlier onset, stronger family history and more rapid decline of pancreatic B-cell function than Swedish patients, suggesting that they have a different form of T2DM compared with Swedish patients.}},
  author       = {{Glans, Forouzan and Elgzyri, Targ and Shaat, Nael and Lindholm, Eero and Apelqvist, Jan and Groop, Leif}},
  issn         = {{1464-5491}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{303--307}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Diabetic Medicine: A journal of the British Diabetic Association}},
  title        = {{Immigrants from the Middle-East have a different form of Type 2 diabetes compared with Swedish patients.}},
  url          = {{http://dx.doi.org/10.1111/j.1464-5491.2007.02366.x}},
  doi          = {{10.1111/j.1464-5491.2007.02366.x}},
  volume       = {{25}},
  year         = {{2008}},
}