Global and local dispersion of ventricular repolarization: endocardial monophasic action potential mapping in swine and humans by using an electro-anatomical mapping system.

Kongstad Rasmussen, Ole; Yuan, Shiwen; Hertervig, Eva; Holm, Magnus; Grins, Edgars; Olsson, Bertil

Global and local dispersion of ventricular repolarization: endocardial monophasic action potential mapping in swine and humans by using an electro-anatomical mapping system.

Mark

Kongstad Rasmussen, Ole ^LU ; Yuan, Shiwen ^LU ; Hertervig, Eva ^LU ; Holm, Magnus ; Grins, Edgars and Olsson, Bertil ^LU (2002) In Journal of Electrocardiology 35(2). p.159-167

Abstract: This article evaluates whether the global dispersion of ventricular repolarization (DVR) can be estimated from measurements between a few adjacent or remote sites. Monophasic action potentials (MAP) were recorded from 61 +/- 18 left (LV) or right ventricular (RV) sites in 10 pigs and 44 +/- 16 LV, or RV sites in 8 patients by using the CARTO mapping system. MAP duration (MAPd) and end-of-repolarization time were calculated at each site and 13 repolarization maps from pigs and 10 from patients were reconstructed. Global dispersions in MAPd and EOR over the LV or RV were compared with the adjacent DVR among 3 - 7 MAPs in areas > or = 0.7 and < or = 1 cm(2) and with the remote DVRs between 2 MAPs with the greatest activation time... (More); This article evaluates whether the global dispersion of ventricular repolarization (DVR) can be estimated from measurements between a few adjacent or remote sites. Monophasic action potentials (MAP) were recorded from 61 +/- 18 left (LV) or right ventricular (RV) sites in 10 pigs and 44 +/- 16 LV, or RV sites in 8 patients by using the CARTO mapping system. MAP duration (MAPd) and end-of-repolarization time were calculated at each site and 13 repolarization maps from pigs and 10 from patients were reconstructed. Global dispersions in MAPd and EOR over the LV or RV were compared with the adjacent DVR among 3 - 7 MAPs in areas > or = 0.7 and < or = 1 cm(2) and with the remote DVRs between 2 MAPs with the greatest activation time difference (remote DVR1) and between the apical and laterobasal LV or RV (remote DVR2). The adjacent dispersions in end-of-repolarization and MAPd were significantly smaller than the global ones, 13 +/- 3 and 12 +/- 3 ms vs. 44 +/- 9 and 42 +/- 12 ms in pigs and 13 +/- 7 and 14 +/- 8 ms vs. 72 +/- 24 and 66 +/- 22 ms in patients. The remote DVR1 (30 +/- 8 and 17 +/- 10 ms in pigs and 40 +/- 28 and 28 +/- 17 ms in patients) and remote DVR2 (16 +/- 7 and 11 +/- 10 ms in pigs and 35 +/- 24 and 21 +/- 21 ms in patients) were also significantly smaller than the global DVRs. In conclusion, global DVR is poorly estimated from MAP recordings from a few adjacent or remote sites, suggesting the importance of obtaining global information in evaluating DVR. (Less)

Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/107661

author

Kongstad Rasmussen, Ole ^LU ; Yuan, Shiwen ^LU ; Hertervig, Eva ^LU ; Holm, Magnus ; Grins, Edgars and Olsson, Bertil ^LU

organization

Cardiology

publishing date

2002

type

Contribution to journal

publication status

published

subject

Cardiac and Cardiovascular Systems

keywords

Ventricular : surgery, Tachycardia, Ventricular : physiopathology, Swine, Optical Rotatory Dispersion, Cardiovascular, Models, Animal, Human, Middle Age, Heart Ventricle : physiopathology, Heart Ventricle : anatomy & histology, Endocardium : physiopathology, Cardiac, Endocardium : anatomy & histology, Action Potentials : physiology, Adult, Aged, Body Surface Potential Mapping : methods, Catheter Ablation, Comparative Study, Electrophysiologic Techniques

in

Journal of Electrocardiology

volume

35

issue

2

pages

159 - 167

publisher

Elsevier

external identifiers

pmid:11953917
wos:000175021400011
scopus:0036224065

ISSN

1532-8430

DOI

10.1054/jelc.2002.31825

language

English

LU publication?

yes

id

351deead-9bac-4880-95bc-c35383ff9ca0 (old id 107661)

alternative location

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11953917&dopt=Abstract

date added to LUP

2016-04-01 11:53:43

date last changed

2022-01-26 19:48:21

@article{351deead-9bac-4880-95bc-c35383ff9ca0,
  abstract     = {{This article evaluates whether the global dispersion of ventricular repolarization (DVR) can be estimated from measurements between a few adjacent or remote sites. Monophasic action potentials (MAP) were recorded from 61 +/- 18 left (LV) or right ventricular (RV) sites in 10 pigs and 44 +/- 16 LV, or RV sites in 8 patients by using the CARTO mapping system. MAP duration (MAPd) and end-of-repolarization time were calculated at each site and 13 repolarization maps from pigs and 10 from patients were reconstructed. Global dispersions in MAPd and EOR over the LV or RV were compared with the adjacent DVR among 3 - 7 MAPs in areas &gt; or = 0.7 and &lt; or = 1 cm(2) and with the remote DVRs between 2 MAPs with the greatest activation time difference (remote DVR1) and between the apical and laterobasal LV or RV (remote DVR2). The adjacent dispersions in end-of-repolarization and MAPd were significantly smaller than the global ones, 13 +/- 3 and 12 +/- 3 ms vs. 44 +/- 9 and 42 +/- 12 ms in pigs and 13 +/- 7 and 14 +/- 8 ms vs. 72 +/- 24 and 66 +/- 22 ms in patients. The remote DVR1 (30 +/- 8 and 17 +/- 10 ms in pigs and 40 +/- 28 and 28 +/- 17 ms in patients) and remote DVR2 (16 +/- 7 and 11 +/- 10 ms in pigs and 35 +/- 24 and 21 +/- 21 ms in patients) were also significantly smaller than the global DVRs. In conclusion, global DVR is poorly estimated from MAP recordings from a few adjacent or remote sites, suggesting the importance of obtaining global information in evaluating DVR.}},
  author       = {{Kongstad Rasmussen, Ole and Yuan, Shiwen and Hertervig, Eva and Holm, Magnus and Grins, Edgars and Olsson, Bertil}},
  issn         = {{1532-8430}},
  keywords     = {{Ventricular : surgery; Tachycardia; Ventricular : physiopathology; Swine; Optical Rotatory Dispersion; Cardiovascular; Models; Animal; Human; Middle Age; Heart Ventricle : physiopathology; Heart Ventricle : anatomy & histology; Endocardium : physiopathology; Cardiac; Endocardium : anatomy & histology; Action Potentials : physiology; Adult; Aged; Body Surface Potential Mapping : methods; Catheter Ablation; Comparative Study; Electrophysiologic Techniques}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{159--167}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Electrocardiology}},
  title        = {{Global and local dispersion of ventricular repolarization: endocardial monophasic action potential mapping in swine and humans by using an electro-anatomical mapping system.}},
  url          = {{http://dx.doi.org/10.1054/jelc.2002.31825}},
  doi          = {{10.1054/jelc.2002.31825}},
  volume       = {{35}},
  year         = {{2002}},
}

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Global and local dispersion of ventricular repolarization: endocardial monophasic action potential mapping in swine and humans by using an electro-anatomical mapping system.