Effects of ethanol intake on lipoprotein lipase activity in adipose tissue of fasting subjects
(1978) In Lipids 13(6). p.433-437- Abstract
- Ethanol (ca. 1 g/kg body weight) was given alone or together with glucose or lipid (mixed triglycerides) perorally to young, fasting subjects. The changes with time (0-6 hr) of lipoprotein lipase activity (LLA) in adipose tissue, plasma glycerol, triglyceride, insulin, blood glucose, and alcohol concentrations were followed. A maximal mean blood alcohol concentration of 0.09% (w/v) was obtained 1 hr after ingestion with no apparent intoxicating effects. Ethanol intake prevented the previously observed [Nilsson-Ehle, P., S. Carlstrom, and P. Belfrage, Scand, J. Clin. Lab. Invest. 35:373 (1975)] glucose-induced rapid elevation of adipose tissue LLA but had small effects on this enzymatic activity when given alone or together with lipid.... (More)
- Ethanol (ca. 1 g/kg body weight) was given alone or together with glucose or lipid (mixed triglycerides) perorally to young, fasting subjects. The changes with time (0-6 hr) of lipoprotein lipase activity (LLA) in adipose tissue, plasma glycerol, triglyceride, insulin, blood glucose, and alcohol concentrations were followed. A maximal mean blood alcohol concentration of 0.09% (w/v) was obtained 1 hr after ingestion with no apparent intoxicating effects. Ethanol intake prevented the previously observed [Nilsson-Ehle, P., S. Carlstrom, and P. Belfrage, Scand, J. Clin. Lab. Invest. 35:373 (1975)] glucose-induced rapid elevation of adipose tissue LLA but had small effects on this enzymatic activity when given alone or together with lipid. Confirming results by others, ethanol intake decreased plasma glycerol concentration and increased plasma triglycerides, especially after intake of lipid. It is suggested that ethanol intake interferes with the normal carbohydrate-induced elevation of adipose tissue LLA after a mixed meal, thereby decreasing the removal capacity for circulating dietary lipid and causing enhanced and prolonged alimentary hyperlipemia. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1102705
- author
- Nilsson-Ehle, Peter LU ; Carlström, Sven and Belfrage, Per LU
- organization
- publishing date
- 1978
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Lipids
- volume
- 13
- issue
- 6
- pages
- 433 - 437
- publisher
- Springer
- external identifiers
-
- pmid:672483
- scopus:0018185016
- ISSN
- 0024-4201
- DOI
- 10.1007/BF02533714
- language
- English
- LU publication?
- yes
- id
- 041ce7f7-a1cc-4bf0-b9b6-22c613e7b56b (old id 1102705)
- date added to LUP
- 2016-04-01 11:45:33
- date last changed
- 2021-01-03 07:20:20
@article{041ce7f7-a1cc-4bf0-b9b6-22c613e7b56b,
abstract = {{Ethanol (ca. 1 g/kg body weight) was given alone or together with glucose or lipid (mixed triglycerides) perorally to young, fasting subjects. The changes with time (0-6 hr) of lipoprotein lipase activity (LLA) in adipose tissue, plasma glycerol, triglyceride, insulin, blood glucose, and alcohol concentrations were followed. A maximal mean blood alcohol concentration of 0.09% (w/v) was obtained 1 hr after ingestion with no apparent intoxicating effects. Ethanol intake prevented the previously observed [Nilsson-Ehle, P., S. Carlstrom, and P. Belfrage, Scand, J. Clin. Lab. Invest. 35:373 (1975)] glucose-induced rapid elevation of adipose tissue LLA but had small effects on this enzymatic activity when given alone or together with lipid. Confirming results by others, ethanol intake decreased plasma glycerol concentration and increased plasma triglycerides, especially after intake of lipid. It is suggested that ethanol intake interferes with the normal carbohydrate-induced elevation of adipose tissue LLA after a mixed meal, thereby decreasing the removal capacity for circulating dietary lipid and causing enhanced and prolonged alimentary hyperlipemia.}},
author = {{Nilsson-Ehle, Peter and Carlström, Sven and Belfrage, Per}},
issn = {{0024-4201}},
language = {{eng}},
number = {{6}},
pages = {{433--437}},
publisher = {{Springer}},
series = {{Lipids}},
title = {{Effects of ethanol intake on lipoprotein lipase activity in adipose tissue of fasting subjects}},
url = {{http://dx.doi.org/10.1007/BF02533714}},
doi = {{10.1007/BF02533714}},
volume = {{13}},
year = {{1978}},
}