Urinary excretion of oligosaccharides induced by galactose given orally or intravenously
(1979) In European Journal of Biochemistry 100(2). p.385-392- Abstract
- The effect of oral administration of galactose, lactose, and sucrose and intravenous injection of galactose on the urinary excretion of blood-group-active oligosaccharides has been studied. Galactose given either as the free sugar, a glycoside (lactose) or a constituent of normal diet was an absolute requirement for the formation and excretion of A-trisaccharide, B-trisaccharide and 2'-fucosylgalactose in blood group A, B and O(H) secretors, respectively. Great individual variation was seen in the amounts of galactose-dependent oligosaccharides excreted. Injection of galactose resulted in excretion of 3-59% of the amount of oligosaccharide formed after oral administration to the same individual. The mean ratio... (More)
- The effect of oral administration of galactose, lactose, and sucrose and intravenous injection of galactose on the urinary excretion of blood-group-active oligosaccharides has been studied. Galactose given either as the free sugar, a glycoside (lactose) or a constituent of normal diet was an absolute requirement for the formation and excretion of A-trisaccharide, B-trisaccharide and 2'-fucosylgalactose in blood group A, B and O(H) secretors, respectively. Great individual variation was seen in the amounts of galactose-dependent oligosaccharides excreted. Injection of galactose resulted in excretion of 3-59% of the amount of oligosaccharide formed after oral administration to the same individual. The mean ratio A-trisaccharide/B-trisaccharide was 2.7 in four blood-group-A1B secretors and 0.22 in three A2B secretors and can thus serve as a parameter for chemical differentiation between the two blood groups. The excretion of larger blood-group-active oligosaccharides, including the A-pentasaccharide, the B-pentasaccharide and lactodifucotetraose, that are normal components in urine from, respectively, starved A, B, and H secretors, was about the same after oral administration of galactose or lactose. The B-trisaccharide was the only oligosaccharide detected in plasma after oral galactose administration to a blood-group-B secretor individual. The concentration was 0.38 mg/l of plasma. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1102716
- author
- Chester, Alan LU ; Hallgren, Peter ; Lundblad, Arne and Messeter, Lisbeth
- organization
- publishing date
- 1979
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Biochemistry
- volume
- 100
- issue
- 2
- pages
- 385 - 392
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:510288
- scopus:0018582651
- ISSN
- 0014-2956
- DOI
- 10.1111/j.1432-1033.1979.00385.pp.x
- language
- English
- LU publication?
- yes
- id
- e80ffcda-e4b5-45fc-9eca-796a81f8b8a8 (old id 1102716)
- date added to LUP
- 2016-04-01 16:26:45
- date last changed
- 2021-01-03 03:39:27
@article{e80ffcda-e4b5-45fc-9eca-796a81f8b8a8,
abstract = {{The effect of oral administration of galactose, lactose, and sucrose and intravenous injection of galactose on the urinary excretion of blood-group-active oligosaccharides has been studied. Galactose given either as the free sugar, a glycoside (lactose) or a constituent of normal diet was an absolute requirement for the formation and excretion of A-trisaccharide, B-trisaccharide and 2'-fucosylgalactose in blood group A, B and O(H) secretors, respectively. Great individual variation was seen in the amounts of galactose-dependent oligosaccharides excreted. Injection of galactose resulted in excretion of 3-59% of the amount of oligosaccharide formed after oral administration to the same individual. The mean ratio A-trisaccharide/B-trisaccharide was 2.7 in four blood-group-A1B secretors and 0.22 in three A2B secretors and can thus serve as a parameter for chemical differentiation between the two blood groups. The excretion of larger blood-group-active oligosaccharides, including the A-pentasaccharide, the B-pentasaccharide and lactodifucotetraose, that are normal components in urine from, respectively, starved A, B, and H secretors, was about the same after oral administration of galactose or lactose. The B-trisaccharide was the only oligosaccharide detected in plasma after oral galactose administration to a blood-group-B secretor individual. The concentration was 0.38 mg/l of plasma.}},
author = {{Chester, Alan and Hallgren, Peter and Lundblad, Arne and Messeter, Lisbeth}},
issn = {{0014-2956}},
language = {{eng}},
number = {{2}},
pages = {{385--392}},
publisher = {{Wiley-Blackwell}},
series = {{European Journal of Biochemistry}},
title = {{Urinary excretion of oligosaccharides induced by galactose given orally or intravenously}},
url = {{http://dx.doi.org/10.1111/j.1432-1033.1979.00385.pp.x}},
doi = {{10.1111/j.1432-1033.1979.00385.pp.x}},
volume = {{100}},
year = {{1979}},
}