Improvement of the plasma lipoprotein pattern after institution of insulin treatment in diabetes mellitus
(1982) In Diabetes Care 5(3). p.322-325- Abstract
- Plasma lipids and lipoproteins were studied in 26 nonobese diabetic patients, either newly diagnosed or unsatisfactorily controlled by oral antidiabetic treatment. Measurements were performed before and 3-4 mo after the institution of insulin treatment. In a subgroup of seven patients, the activities of lipoprotein lipase (LPL) and hepatic lipase (HL) in postheparin plasma and the elimination rate of exogenous triglyceride were also monitored. After beginning insulin treatment, diabetic control was improved as demonstrated by decreasing levels of HbA1. Mean plasma cholesterol and triglyceride levels decreased by about 10% (P less than 0.01) and 40% (P less than 0.05), respectively. The decrease in plasma cholesterol was largely accounted... (More)
- Plasma lipids and lipoproteins were studied in 26 nonobese diabetic patients, either newly diagnosed or unsatisfactorily controlled by oral antidiabetic treatment. Measurements were performed before and 3-4 mo after the institution of insulin treatment. In a subgroup of seven patients, the activities of lipoprotein lipase (LPL) and hepatic lipase (HL) in postheparin plasma and the elimination rate of exogenous triglyceride were also monitored. After beginning insulin treatment, diabetic control was improved as demonstrated by decreasing levels of HbA1. Mean plasma cholesterol and triglyceride levels decreased by about 10% (P less than 0.01) and 40% (P less than 0.05), respectively. The decrease in plasma cholesterol was largely accounted for by a fall in LDL cholesterol levels (-8%, P less than 0.05), while plasma HDL cholesterol concentrations increased by about 12% (P less than 0.01). The elimination rate of exogenous triglycerides increased significantly. There was a suggestive, but not significant, increase in LPL activity while the HL activity remained unchanged. It is concluded that the improved diabetic control after institution of insulin treatment results in a significant improvement of the plasma lipoprotein profile. Since the improvement of the lipoprotein pattern is not strictly correlated to the amelioration of indices reflecting glucose transport, we suggest that the plasma lipoprotein pattern may provide an additional tool for monitoring the degree of control in diabetes mellitus. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1102987
- author
- Agardh, Carl-David LU ; Nilsson-Ehle, Peter LU and Schersten, B
- organization
- publishing date
- 1982
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes Care
- volume
- 5
- issue
- 3
- pages
- 322 - 325
- publisher
- American Diabetes Association
- external identifiers
-
- pmid:6756840
- scopus:0020077402
- ISSN
- 1935-5548
- DOI
- 10.2337/diacare.5.3.322
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Clinical Chemistry and Pharmacology (013250300), Unit on Vascular Diabetic Complications (013241510)
- id
- 4a3ea03e-5f54-4401-a677-450789cd7e31 (old id 1102987)
- date added to LUP
- 2016-04-01 15:48:46
- date last changed
- 2021-01-03 04:59:54
@article{4a3ea03e-5f54-4401-a677-450789cd7e31,
abstract = {{Plasma lipids and lipoproteins were studied in 26 nonobese diabetic patients, either newly diagnosed or unsatisfactorily controlled by oral antidiabetic treatment. Measurements were performed before and 3-4 mo after the institution of insulin treatment. In a subgroup of seven patients, the activities of lipoprotein lipase (LPL) and hepatic lipase (HL) in postheparin plasma and the elimination rate of exogenous triglyceride were also monitored. After beginning insulin treatment, diabetic control was improved as demonstrated by decreasing levels of HbA1. Mean plasma cholesterol and triglyceride levels decreased by about 10% (P less than 0.01) and 40% (P less than 0.05), respectively. The decrease in plasma cholesterol was largely accounted for by a fall in LDL cholesterol levels (-8%, P less than 0.05), while plasma HDL cholesterol concentrations increased by about 12% (P less than 0.01). The elimination rate of exogenous triglycerides increased significantly. There was a suggestive, but not significant, increase in LPL activity while the HL activity remained unchanged. It is concluded that the improved diabetic control after institution of insulin treatment results in a significant improvement of the plasma lipoprotein profile. Since the improvement of the lipoprotein pattern is not strictly correlated to the amelioration of indices reflecting glucose transport, we suggest that the plasma lipoprotein pattern may provide an additional tool for monitoring the degree of control in diabetes mellitus.}},
author = {{Agardh, Carl-David and Nilsson-Ehle, Peter and Schersten, B}},
issn = {{1935-5548}},
language = {{eng}},
number = {{3}},
pages = {{322--325}},
publisher = {{American Diabetes Association}},
series = {{Diabetes Care}},
title = {{Improvement of the plasma lipoprotein pattern after institution of insulin treatment in diabetes mellitus}},
url = {{http://dx.doi.org/10.2337/diacare.5.3.322}},
doi = {{10.2337/diacare.5.3.322}},
volume = {{5}},
year = {{1982}},
}