Inhibitory effect of honey bee venom on immune complex mediated leukocyte migration into rabbit knee-joints
(1984) In Agents and Actions 14(5-6). p.662-666- Abstract
- The anti-inflammatory effect of purified honey bee venom (HBV) was studied using a recently described animal model in which preformed immune complexes were injected into rabbit knee-joints. As little as a single injection of 1.2 micrograms HBV/kg body weight subcutaneously significantly reduced the immune complex induced joint inflammation as measured by reduction in leukocyte counts in the joint fluid. This decrease was obvious 3 and 6 but not 9 hours after induction of the inflammation. There was no significant effect on leukocyte random migration, chemotactic responsiveness or phagocytosis, indicating that HBV did not interfere with normal phagocyte motility and ingestion. The modifying effects by HBV on the inflammatory response to... (More)
- The anti-inflammatory effect of purified honey bee venom (HBV) was studied using a recently described animal model in which preformed immune complexes were injected into rabbit knee-joints. As little as a single injection of 1.2 micrograms HBV/kg body weight subcutaneously significantly reduced the immune complex induced joint inflammation as measured by reduction in leukocyte counts in the joint fluid. This decrease was obvious 3 and 6 but not 9 hours after induction of the inflammation. There was no significant effect on leukocyte random migration, chemotactic responsiveness or phagocytosis, indicating that HBV did not interfere with normal phagocyte motility and ingestion. The modifying effects by HBV on the inflammatory response to immune complexes in vivo is most likely due to interference with other components of the inflammatory response. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1103162
- author
- Thomsen, P ; Bjursten, Lars Magnus LU ; Ahlstedt, S ; Bagge, U and Bjorksten, B
- organization
- publishing date
- 1984
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Agents and Actions
- volume
- 14
- issue
- 5-6
- pages
- 662 - 666
- publisher
- Birkhäuser Verlag
- external identifiers
-
- pmid:6475661
- scopus:0021443282
- ISSN
- 0065-4299
- DOI
- 10.1007/BF01978904
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Bioimplant Research (013242910)
- id
- ca331856-029a-435b-bd0e-061fffcc9024 (old id 1103162)
- date added to LUP
- 2016-04-01 16:01:00
- date last changed
- 2021-01-03 09:30:59
@article{ca331856-029a-435b-bd0e-061fffcc9024,
abstract = {{The anti-inflammatory effect of purified honey bee venom (HBV) was studied using a recently described animal model in which preformed immune complexes were injected into rabbit knee-joints. As little as a single injection of 1.2 micrograms HBV/kg body weight subcutaneously significantly reduced the immune complex induced joint inflammation as measured by reduction in leukocyte counts in the joint fluid. This decrease was obvious 3 and 6 but not 9 hours after induction of the inflammation. There was no significant effect on leukocyte random migration, chemotactic responsiveness or phagocytosis, indicating that HBV did not interfere with normal phagocyte motility and ingestion. The modifying effects by HBV on the inflammatory response to immune complexes in vivo is most likely due to interference with other components of the inflammatory response.}},
author = {{Thomsen, P and Bjursten, Lars Magnus and Ahlstedt, S and Bagge, U and Bjorksten, B}},
issn = {{0065-4299}},
language = {{eng}},
number = {{5-6}},
pages = {{662--666}},
publisher = {{Birkhäuser Verlag}},
series = {{Agents and Actions}},
title = {{Inhibitory effect of honey bee venom on immune complex mediated leukocyte migration into rabbit knee-joints}},
url = {{http://dx.doi.org/10.1007/BF01978904}},
doi = {{10.1007/BF01978904}},
volume = {{14}},
year = {{1984}},
}