Complex karyotypic anomalies in a bizarre leiomyoma of the uterus.
Nilbert, Mef LU ; Heim, Sverre LU ; Mandahl, Nils LU ; Flodérus, Ulla-Maria ; Willén, Helena ; Baldetorp, Bo LU and Mitelman, Felix LU
(1989)
In Genes, Chromosomes and Cancer
1(2).
p.131-134
- Abstract
- Cytogenetic investigation of short-term cultures from a bizarre leiomyoma of the uterus, a tumor type not hitherto karyotypically characterized, revealed two abnormal clones with multiple complex rearrangements. Three-fourths of the aberrant cells were hypodiploid with the composite karyotype 38-44, XX,-6,-7,-10,-11,+20,-22, r(1), der(2) (:2p23cen2q13::1q211qter), der(2)t(2;9)(p21;q13), t(5;?)(q35;?), t(5;?),(q35;?), + der(5)t(5;15)(q11;q15), der(8)t(8;11)(q24;q13), t(15;?)(p12;?), der(16)t(12;16)(q13;p13),+r,+mar. The remaining abnormal mitoses were hypotetraploid, with chromosome numbers ranging from 74 to 86. These massively rearranged cells showed the same markers that were found in the hypodiploid clone, but in duplicate, indicating... (More)
- Cytogenetic investigation of short-term cultures from a bizarre leiomyoma of the uterus, a tumor type not hitherto karyotypically characterized, revealed two abnormal clones with multiple complex rearrangements. Three-fourths of the aberrant cells were hypodiploid with the composite karyotype 38-44, XX,-6,-7,-10,-11,+20,-22, r(1), der(2) (:2p23cen2q13::1q211qter), der(2)t(2;9)(p21;q13), t(5;?)(q35;?), t(5;?),(q35;?), + der(5)t(5;15)(q11;q15), der(8)t(8;11)(q24;q13), t(15;?)(p12;?), der(16)t(12;16)(q13;p13),+r,+mar. The remaining abnormal mitoses were hypotetraploid, with chromosome numbers ranging from 74 to 86. These massively rearranged cells showed the same markers that were found in the hypodiploid clone, but in duplicate, indicating that this clone had arisen through polyploidization of hypodiploid cells. Flow cytometry revealed a DNA index of 1.03. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1104766
- author
- Nilbert, Mef
LU
; Heim, Sverre
LU
; Mandahl, Nils
LU
; Flodérus, Ulla-Maria
; Willén, Helena
; Baldetorp, Bo
LU
and Mitelman, Felix
LU
- organization
- publishing date
- 1989
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Genes, Chromosomes and Cancer
- volume
- 1
- issue
- 2
- pages
- 131 - 134
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:0024910245
- ISSN
- 1045-2257
- DOI
- 10.1002/gcc.2870010204
- language
- English
- LU publication?
- yes
- id
- f041931d-1f6f-4b4f-90ae-e7feeeee85d0 (old id 1104766)
- date added to LUP
- 2016-04-01 12:27:28
- date last changed
- 2021-09-19 05:44:47
@article{f041931d-1f6f-4b4f-90ae-e7feeeee85d0,
abstract = {{Cytogenetic investigation of short-term cultures from a bizarre leiomyoma of the uterus, a tumor type not hitherto karyotypically characterized, revealed two abnormal clones with multiple complex rearrangements. Three-fourths of the aberrant cells were hypodiploid with the composite karyotype 38-44, XX,-6,-7,-10,-11,+20,-22, r(1), der(2) (:2p23cen2q13::1q211qter), der(2)t(2;9)(p21;q13), t(5;?)(q35;?), t(5;?),(q35;?), + der(5)t(5;15)(q11;q15), der(8)t(8;11)(q24;q13), t(15;?)(p12;?), der(16)t(12;16)(q13;p13),+r,+mar. The remaining abnormal mitoses were hypotetraploid, with chromosome numbers ranging from 74 to 86. These massively rearranged cells showed the same markers that were found in the hypodiploid clone, but in duplicate, indicating that this clone had arisen through polyploidization of hypodiploid cells. Flow cytometry revealed a DNA index of 1.03.}},
author = {{Nilbert, Mef and Heim, Sverre and Mandahl, Nils and Flodérus, Ulla-Maria and Willén, Helena and Baldetorp, Bo and Mitelman, Felix}},
issn = {{1045-2257}},
language = {{eng}},
number = {{2}},
pages = {{131--134}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Genes, Chromosomes and Cancer}},
title = {{Complex karyotypic anomalies in a bizarre leiomyoma of the uterus.}},
url = {{http://dx.doi.org/10.1002/gcc.2870010204}},
doi = {{10.1002/gcc.2870010204}},
volume = {{1}},
year = {{1989}},
}