Effects of isradipine, a new calcium antagonist, on postpartum uterine activity
(1989) In Acta Obstetricia et Gynecologica Scandinavica 68(8). p.725-730- Abstract
- The effects of a new calcium antagonist, isradipine (PN 200-110) on postpartum uterine activity and the maternal cardiovascular system were investigated. Uterine activity was recorded by a microtip transducer catheter inserted transcervically within 45 min of normal vaginal delivery. 0.5 mg of isradipine was given as a bolus injection during 5 min to 7 women with spontaneous uterine activity and 1 mg was given during a 15-min period to another 8 women with oxytocin-stimulated uterine activity. Matched controls with similar pre-injection activity (+/- 5%) but not given the drug were selected for comparison. The effects of the drug in 3 women (given 1 mg of isradipine) were compared with those in matched controls and in women given 0.25 mg... (More)
- The effects of a new calcium antagonist, isradipine (PN 200-110) on postpartum uterine activity and the maternal cardiovascular system were investigated. Uterine activity was recorded by a microtip transducer catheter inserted transcervically within 45 min of normal vaginal delivery. 0.5 mg of isradipine was given as a bolus injection during 5 min to 7 women with spontaneous uterine activity and 1 mg was given during a 15-min period to another 8 women with oxytocin-stimulated uterine activity. Matched controls with similar pre-injection activity (+/- 5%) but not given the drug were selected for comparison. The effects of the drug in 3 women (given 1 mg of isradipine) were compared with those in matched controls and in women given 0.25 mg of terbutalin i.v. as a bolus injection. Isradipine had a marked inhibitory effect on both spontaneous and oxytocin-stimulated uterine activity. The inhibitory effect of 1 mg of isradipine seemed comparable to that of 0.25 mg of terbutalin. The inhibition occurred within 1-2 min after the injection and was sustained throughout the study period (2 h). A transient reduction of the systolic (mean maximum decrease 10-15%) and diastolic blood pressure (mean maximum decrease 15-20%) was seen, particularly during the injection period. Hypotension (systolic blood pressure less than 80 mmHg) was not recorded. A moderate increase in pulse rate (mean maximum increase 22-27%) was seen in all cases. The results show that isradipine given as a bolus injection can inhibit early postpartum uterine activity, with minimal side effects. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1104825
- author
- Ingemarsson, Ingemar LU ; Arulkumaran, S ; Wide-Swensson, Dag LU ; Forman, A ; Andersson, K E and Ratnam, S S
- organization
- publishing date
- 1989
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Obstetricia et Gynecologica Scandinavica
- volume
- 68
- issue
- 8
- pages
- 725 - 730
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:2534341
- scopus:0024936279
- ISSN
- 1600-0412
- DOI
- 10.3109/00016348909006146
- language
- English
- LU publication?
- yes
- id
- 0f9d1102-7baf-43c9-bea0-f34029a8be09 (old id 1104825)
- date added to LUP
- 2016-04-01 16:45:35
- date last changed
- 2021-01-03 08:30:30
@article{0f9d1102-7baf-43c9-bea0-f34029a8be09,
abstract = {{The effects of a new calcium antagonist, isradipine (PN 200-110) on postpartum uterine activity and the maternal cardiovascular system were investigated. Uterine activity was recorded by a microtip transducer catheter inserted transcervically within 45 min of normal vaginal delivery. 0.5 mg of isradipine was given as a bolus injection during 5 min to 7 women with spontaneous uterine activity and 1 mg was given during a 15-min period to another 8 women with oxytocin-stimulated uterine activity. Matched controls with similar pre-injection activity (+/- 5%) but not given the drug were selected for comparison. The effects of the drug in 3 women (given 1 mg of isradipine) were compared with those in matched controls and in women given 0.25 mg of terbutalin i.v. as a bolus injection. Isradipine had a marked inhibitory effect on both spontaneous and oxytocin-stimulated uterine activity. The inhibitory effect of 1 mg of isradipine seemed comparable to that of 0.25 mg of terbutalin. The inhibition occurred within 1-2 min after the injection and was sustained throughout the study period (2 h). A transient reduction of the systolic (mean maximum decrease 10-15%) and diastolic blood pressure (mean maximum decrease 15-20%) was seen, particularly during the injection period. Hypotension (systolic blood pressure less than 80 mmHg) was not recorded. A moderate increase in pulse rate (mean maximum increase 22-27%) was seen in all cases. The results show that isradipine given as a bolus injection can inhibit early postpartum uterine activity, with minimal side effects.}},
author = {{Ingemarsson, Ingemar and Arulkumaran, S and Wide-Swensson, Dag and Forman, A and Andersson, K E and Ratnam, S S}},
issn = {{1600-0412}},
language = {{eng}},
number = {{8}},
pages = {{725--730}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Obstetricia et Gynecologica Scandinavica}},
title = {{Effects of isradipine, a new calcium antagonist, on postpartum uterine activity}},
url = {{http://dx.doi.org/10.3109/00016348909006146}},
doi = {{10.3109/00016348909006146}},
volume = {{68}},
year = {{1989}},
}