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Actions of platelet-activating factor on isolated feline and human cerebral arteries

Uski, Tore LU and Reinstrup, Peter LU (1990) In Journal of Cerebral Blood Flow and Metabolism 10(3). p.428-431
Abstract
The effects of platelet-activating factor (PAF) were studied on isolated feline basilar arteries (BAs) and human pial arteries (PAs). PAF contracted the BAs by 67% of the contraction induced by 124 mM K+ and the PAs by 80%. The contraction in BAs was unaffected by both indomethacin and the thromboxane receptor antagonist AH23848. PAF relaxed prostaglandin F2 alpha-contracted arteries. In BAs 10(-6) M PAF reduced the contraction by 17% and in PAs by 47%. The relaxant effects in both arteries were unaffected by indomethacin. In conclusion, PAF can act both as a constrictor and as a dilator of isolated feline and human cerebral arteries. The effects are seemingly unrelated to vascular prostanoid production.
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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Cerebral Blood Flow and Metabolism
volume
10
issue
3
pages
428 - 431
publisher
Nature Publishing Group
external identifiers
  • pmid:2329129
  • scopus:0025228442
ISSN
1559-7016
language
English
LU publication?
yes
id
995303ba-8db7-456e-84e5-4179dd0c6770 (old id 1105159)
date added to LUP
2016-04-01 16:09:29
date last changed
2021-09-19 05:33:58
@article{995303ba-8db7-456e-84e5-4179dd0c6770,
  abstract     = {{The effects of platelet-activating factor (PAF) were studied on isolated feline basilar arteries (BAs) and human pial arteries (PAs). PAF contracted the BAs by 67% of the contraction induced by 124 mM K+ and the PAs by 80%. The contraction in BAs was unaffected by both indomethacin and the thromboxane receptor antagonist AH23848. PAF relaxed prostaglandin F2 alpha-contracted arteries. In BAs 10(-6) M PAF reduced the contraction by 17% and in PAs by 47%. The relaxant effects in both arteries were unaffected by indomethacin. In conclusion, PAF can act both as a constrictor and as a dilator of isolated feline and human cerebral arteries. The effects are seemingly unrelated to vascular prostanoid production.}},
  author       = {{Uski, Tore and Reinstrup, Peter}},
  issn         = {{1559-7016}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{428--431}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Journal of Cerebral Blood Flow and Metabolism}},
  title        = {{Actions of platelet-activating factor on isolated feline and human cerebral arteries}},
  volume       = {{10}},
  year         = {{1990}},
}