Serotonin-stimulated phosphoinositide hydrolysis in platelets from post-withdrawal alcoholics
(1992) In Alcohol and Alcoholism 27(6). p.607-612- Abstract
- It has previously been reported that serotonin-stimulated second messenger formation is inhibited in platelets from alcoholics undergoing detoxification. Serotonin-stimulated signal transduction was therefore analysed in platelets from young post-withdrawal alcoholics to elucidate whether the previously reported inhibition is a state or trait marker of alcoholism. No difference between post-withdrawal alcoholics and controls was found with regard to serotonin-stimulated [32P]-phosphatidylinositol 4,5-bisphosphate hydrolysis or [32P]-phosphatidic acid formation. The results indicate that the inhibited serotonin2 receptor function seen in alcoholics undergoing detoxification is a state-dependent rather than a trait-dependent marker.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1106768
- author
- Simonsson, Per LU ; Berglund, Mats LU ; Oreland, Lars ; Moberg, Anne-Louise and Alling, Christer LU
- organization
- publishing date
- 1992
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Alcohol and Alcoholism
- volume
- 27
- issue
- 6
- pages
- 607 - 612
- publisher
- Oxford University Press
- external identifiers
-
- pmid:1337965
- scopus:0027081791
- ISSN
- 1464-3502
- language
- English
- LU publication?
- yes
- id
- b5aab4d1-c787-4b9d-a8a8-e740b4251de1 (old id 1106768)
- alternative location
- http://alcalc.oxfordjournals.org/cgi/reprint/27/6/607
- date added to LUP
- 2016-04-01 12:31:03
- date last changed
- 2021-01-03 10:42:13
@article{b5aab4d1-c787-4b9d-a8a8-e740b4251de1,
abstract = {{It has previously been reported that serotonin-stimulated second messenger formation is inhibited in platelets from alcoholics undergoing detoxification. Serotonin-stimulated signal transduction was therefore analysed in platelets from young post-withdrawal alcoholics to elucidate whether the previously reported inhibition is a state or trait marker of alcoholism. No difference between post-withdrawal alcoholics and controls was found with regard to serotonin-stimulated [32P]-phosphatidylinositol 4,5-bisphosphate hydrolysis or [32P]-phosphatidic acid formation. The results indicate that the inhibited serotonin2 receptor function seen in alcoholics undergoing detoxification is a state-dependent rather than a trait-dependent marker.}},
author = {{Simonsson, Per and Berglund, Mats and Oreland, Lars and Moberg, Anne-Louise and Alling, Christer}},
issn = {{1464-3502}},
language = {{eng}},
number = {{6}},
pages = {{607--612}},
publisher = {{Oxford University Press}},
series = {{Alcohol and Alcoholism}},
title = {{Serotonin-stimulated phosphoinositide hydrolysis in platelets from post-withdrawal alcoholics}},
url = {{http://alcalc.oxfordjournals.org/cgi/reprint/27/6/607}},
volume = {{27}},
year = {{1992}},
}