Effects of nerve growth factor on X-irradiated reaggregation cultures of rat brain cells
Dimberg, Y ; Aspberg, Anders LU
and Tottmar, O
(1993)
In International Journal of Radiation Biology
64(6).
p.731-737
- Abstract
- The effects of exogenously added nerve growth factor (NGF) on reaggregation cultures of foetal rat brain cells after X-irradiation with 2 Gy were studied. Irradiation caused decreased protein and DNA levels, which was not prevented by NGF. The activities of the cholinergic marker enzymes choline acetyl transferase and acetylcholine esterase were increased in irradiated cultures. However, no difference in the activities of these enzymes was found between irradiated and unirradiated NGF-treated cultures. Irradiation did not affect the activity of the marker enzyme for oligodendrocytes (2',3'-cyclic nucleotide 3'-phosphodiesterase), but caused an increase in the astrocyte marker (glutamine synthetase) activity. This effect on astrocytes was... (More)
- The effects of exogenously added nerve growth factor (NGF) on reaggregation cultures of foetal rat brain cells after X-irradiation with 2 Gy were studied. Irradiation caused decreased protein and DNA levels, which was not prevented by NGF. The activities of the cholinergic marker enzymes choline acetyl transferase and acetylcholine esterase were increased in irradiated cultures. However, no difference in the activities of these enzymes was found between irradiated and unirradiated NGF-treated cultures. Irradiation did not affect the activity of the marker enzyme for oligodendrocytes (2',3'-cyclic nucleotide 3'-phosphodiesterase), but caused an increase in the astrocyte marker (glutamine synthetase) activity. This effect on astrocytes was prevented by NGF. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1107660
- author
- Dimberg, Y
; Aspberg, Anders
LU
and Tottmar, O
- publishing date
- 1993
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Radiation Biology
- volume
- 64
- issue
- 6
- pages
- 731 - 737
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:7903341
- scopus:0027135272
- ISSN
- 0955-3002
- DOI
- 10.1080/09553009314551981
- language
- English
- LU publication?
- no
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Connective Tissue Biology (013230151)
- id
- 7ff09b7c-8843-400c-b0a2-33d46c660870 (old id 1107660)
- date added to LUP
- 2016-04-01 12:30:19
- date last changed
- 2021-01-03 04:48:28
@article{7ff09b7c-8843-400c-b0a2-33d46c660870,
abstract = {{The effects of exogenously added nerve growth factor (NGF) on reaggregation cultures of foetal rat brain cells after X-irradiation with 2 Gy were studied. Irradiation caused decreased protein and DNA levels, which was not prevented by NGF. The activities of the cholinergic marker enzymes choline acetyl transferase and acetylcholine esterase were increased in irradiated cultures. However, no difference in the activities of these enzymes was found between irradiated and unirradiated NGF-treated cultures. Irradiation did not affect the activity of the marker enzyme for oligodendrocytes (2',3'-cyclic nucleotide 3'-phosphodiesterase), but caused an increase in the astrocyte marker (glutamine synthetase) activity. This effect on astrocytes was prevented by NGF.}},
author = {{Dimberg, Y and Aspberg, Anders and Tottmar, O}},
issn = {{0955-3002}},
language = {{eng}},
number = {{6}},
pages = {{731--737}},
publisher = {{Taylor & Francis}},
series = {{International Journal of Radiation Biology}},
title = {{Effects of nerve growth factor on X-irradiated reaggregation cultures of rat brain cells}},
url = {{http://dx.doi.org/10.1080/09553009314551981}},
doi = {{10.1080/09553009314551981}},
volume = {{64}},
year = {{1993}},
}