Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Suppressed epileptogenesis in BDNF mutant mice

Kokaia, Merab LU ; Ernfors, Patrik ; Kokaia, Zaal LU orcid ; Elmer, Eskil LU orcid ; Jaenisch, Rudolf and Lindvall, Olle LU (1995) In Experimental Neurology 133(2). p.215-224
Abstract
Kindling is an animal model of epilepsy in which repeated electrical stimulations lead to progressive and permanent amplification of seizure activity, culminating in generalized convulsions. Each brief period of seizure activity during kindling epileptogenesis causes a marked, transient increase of the synthesis of brain-derived neurotrophic factor (BDNF) in cortical and hippocampal neurons. We find that the development of kindling is markedly suppressed in mice heterozygous for a deletion of the BDNF gene. In contrast, the maintenance of kindling is unaffected. The mutant mice show lower levels of BDNF mRNA in cortical and hippocampal neurons after seizures than do wild-type mice. Hippocampal mossy fiber sprouting is augmented in BDNF... (More)
Kindling is an animal model of epilepsy in which repeated electrical stimulations lead to progressive and permanent amplification of seizure activity, culminating in generalized convulsions. Each brief period of seizure activity during kindling epileptogenesis causes a marked, transient increase of the synthesis of brain-derived neurotrophic factor (BDNF) in cortical and hippocampal neurons. We find that the development of kindling is markedly suppressed in mice heterozygous for a deletion of the BDNF gene. In contrast, the maintenance of kindling is unaffected. The mutant mice show lower levels of BDNF mRNA in cortical and hippocampal neurons after seizures than do wild-type mice. Hippocampal mossy fiber sprouting is augmented in BDNF mutants but there are no other morphological abnormalities. These results show that BDNF plays an important role in establishing hyperexcitability during epileptogenesis, probably by increasing efficacy in stimulated synapses. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Experimental Neurology
volume
133
issue
2
pages
215 - 224
publisher
Elsevier
external identifiers
  • pmid:7649227
  • scopus:0029160413
  • pmid:7649227
ISSN
0014-4886
DOI
10.1006/exnr.1995.1024
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neurology, Lund (013027000), Laboratory for Experimental Brain Research (013041000)
id
e2c18cea-7a19-42f4-8f4f-069ff019deb8 (old id 1108973)
date added to LUP
2016-04-01 11:53:07
date last changed
2021-09-19 03:33:44
@article{e2c18cea-7a19-42f4-8f4f-069ff019deb8,
  abstract     = {{Kindling is an animal model of epilepsy in which repeated electrical stimulations lead to progressive and permanent amplification of seizure activity, culminating in generalized convulsions. Each brief period of seizure activity during kindling epileptogenesis causes a marked, transient increase of the synthesis of brain-derived neurotrophic factor (BDNF) in cortical and hippocampal neurons. We find that the development of kindling is markedly suppressed in mice heterozygous for a deletion of the BDNF gene. In contrast, the maintenance of kindling is unaffected. The mutant mice show lower levels of BDNF mRNA in cortical and hippocampal neurons after seizures than do wild-type mice. Hippocampal mossy fiber sprouting is augmented in BDNF mutants but there are no other morphological abnormalities. These results show that BDNF plays an important role in establishing hyperexcitability during epileptogenesis, probably by increasing efficacy in stimulated synapses.}},
  author       = {{Kokaia, Merab and Ernfors, Patrik and Kokaia, Zaal and Elmer, Eskil and Jaenisch, Rudolf and Lindvall, Olle}},
  issn         = {{0014-4886}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{215--224}},
  publisher    = {{Elsevier}},
  series       = {{Experimental Neurology}},
  title        = {{Suppressed epileptogenesis in BDNF mutant mice}},
  url          = {{http://dx.doi.org/10.1006/exnr.1995.1024}},
  doi          = {{10.1006/exnr.1995.1024}},
  volume       = {{133}},
  year         = {{1995}},
}