Increased arterial stiffness in women, but not in men, with IDDM
Rydén Ahlgren, Åsa LU
; Länne, Toste
; Wollmer, Per
LU
; Sonesson, Björn
LU
; Hansen, F
and Sundkvist, Göran
LU
(1995)
In Diabetologia
38(9).
p.1082-1089
- Abstract
- For unknown reasons, there is a greater increase in the risk for cardiovascular complications in diabetic women than in diabetic men. Our aim was to study gender-related differences in the mechanical properties of the great arteries in patients with insulin-dependent diabetes mellitus (IDDM) but free from known cardiovascular and cerebrovascular complications. We measured arterial stiffness (beta, inversely related to arterial compliance) in the abdominal aorta and the common carotid artery non-invasively using echo-tracking sonography in 30 women (mean age 34 years, range 20-61) and 26 men (mean age 38 years, range 22-56) with IDDM. The results were compared with those of healthy individuals of corresponding age and gender. The results... (More)
- For unknown reasons, there is a greater increase in the risk for cardiovascular complications in diabetic women than in diabetic men. Our aim was to study gender-related differences in the mechanical properties of the great arteries in patients with insulin-dependent diabetes mellitus (IDDM) but free from known cardiovascular and cerebrovascular complications. We measured arterial stiffness (beta, inversely related to arterial compliance) in the abdominal aorta and the common carotid artery non-invasively using echo-tracking sonography in 30 women (mean age 34 years, range 20-61) and 26 men (mean age 38 years, range 22-56) with IDDM. The results were compared with those of healthy individuals of corresponding age and gender. The results showed a marked gender-difference in changes of arterial stiffness. Arterial stiffness was increased in both the abdominal aorta and the common carotid artery in diabetic women compared to control women (p = 0.0001 and p = 0.0076, respectively). In contrast, there was no significant difference in stiffness of the abdominal aorta or the common carotid artery between the diabetic men and the control men (p = 0.69 and p = 0.39, respectively). In conclusion, this study has shown that stiffness of the aorta and the common carotid artery is increased in diabetic women but not in diabetic men. Increased arterial stiffness in diabetic women may be a pathogenic factor which could help to explain the gender-related differences in the risk for cardiovascular and cerebrovascular complications in diabetic subjects. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1109598
- author
- Rydén Ahlgren, Åsa
LU
; Länne, Toste
; Wollmer, Per
LU
; Sonesson, Björn
LU
; Hansen, F
and Sundkvist, Göran
LU
- organization
- publishing date
- 1995
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Ultrasonic echo-tracking, insulin-dependent diabetes mellitus, arterial stiffness, gender-difference, arterial compliance
- in
- Diabetologia
- volume
- 38
- issue
- 9
- pages
- 1082 - 1089
- publisher
- Springer
- external identifiers
-
- pmid:8591823
- scopus:0029087756
- ISSN
- 1432-0428
- DOI
- 10.1007/BF00402179
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Diabetes Epidemiology and Neuropathy (013241560), Emergency medicine/Medicine/Surgery (013240200), Clinical Physiology and Nuclear Medicine Unit (013242320)
- id
- 05430810-e02c-44c4-8930-1344c5a1bf85 (old id 1109598)
- date added to LUP
- 2016-04-01 12:01:54
- date last changed
- 2023-09-01 16:38:31
@article{05430810-e02c-44c4-8930-1344c5a1bf85,
abstract = {{For unknown reasons, there is a greater increase in the risk for cardiovascular complications in diabetic women than in diabetic men. Our aim was to study gender-related differences in the mechanical properties of the great arteries in patients with insulin-dependent diabetes mellitus (IDDM) but free from known cardiovascular and cerebrovascular complications. We measured arterial stiffness (beta, inversely related to arterial compliance) in the abdominal aorta and the common carotid artery non-invasively using echo-tracking sonography in 30 women (mean age 34 years, range 20-61) and 26 men (mean age 38 years, range 22-56) with IDDM. The results were compared with those of healthy individuals of corresponding age and gender. The results showed a marked gender-difference in changes of arterial stiffness. Arterial stiffness was increased in both the abdominal aorta and the common carotid artery in diabetic women compared to control women (p = 0.0001 and p = 0.0076, respectively). In contrast, there was no significant difference in stiffness of the abdominal aorta or the common carotid artery between the diabetic men and the control men (p = 0.69 and p = 0.39, respectively). In conclusion, this study has shown that stiffness of the aorta and the common carotid artery is increased in diabetic women but not in diabetic men. Increased arterial stiffness in diabetic women may be a pathogenic factor which could help to explain the gender-related differences in the risk for cardiovascular and cerebrovascular complications in diabetic subjects.}},
author = {{Rydén Ahlgren, Åsa and Länne, Toste and Wollmer, Per and Sonesson, Björn and Hansen, F and Sundkvist, Göran}},
issn = {{1432-0428}},
keywords = {{Ultrasonic echo-tracking; insulin-dependent diabetes mellitus; arterial stiffness; gender-difference; arterial compliance}},
language = {{eng}},
number = {{9}},
pages = {{1082--1089}},
publisher = {{Springer}},
series = {{Diabetologia}},
title = {{Increased arterial stiffness in women, but not in men, with IDDM}},
url = {{http://dx.doi.org/10.1007/BF00402179}},
doi = {{10.1007/BF00402179}},
volume = {{38}},
year = {{1995}},
}