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The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase

Rosengren, Evald LU ; Åman, Pierre ; Thelin, Sofia ; Hansson, Christer LU ; Ahlfors, Stefan LU ; Björk, Peter LU ; Jacobsson, Lars and Rorsman, Hans LU (1997) In FEBS Letters 417(1). p.85-88
Abstract
A macrophage migration inhibitory factor (MIF), originally described as a product of activated lymphocytes, has been defined as a 12 kDa protein, expressed in a wide variety of tissues. Here MIF is identified as a phenylpyruvate tautomerase (EC 5.3.2.1) having p-hydroxyphenylpyruvate and phenylpyruvate as its natural substrates. The definition of MIF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine.
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Macrophage migration inhibitory factor, Phenylpyruvate tautomerase, Dopachrome tautomerase, Cytokine
in
FEBS Letters
volume
417
issue
1
pages
85 - 88
publisher
Wiley-Blackwell
external identifiers
  • pmid:9395080
  • scopus:0343580469
ISSN
1873-3468
DOI
10.1016/S0014-5793(97)01261-1
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Department of Dermatology and Venereology (Lund) (013006000), Department of Experimental Medical Science (013210000)
id
51fc7f63-7860-4422-845b-554d65d03607 (old id 1112115)
date added to LUP
2016-04-01 15:59:27
date last changed
2022-03-22 07:38:13
@article{51fc7f63-7860-4422-845b-554d65d03607,
  abstract     = {{A macrophage migration inhibitory factor (MIF), originally described as a product of activated lymphocytes, has been defined as a 12 kDa protein, expressed in a wide variety of tissues. Here MIF is identified as a phenylpyruvate tautomerase (EC 5.3.2.1) having p-hydroxyphenylpyruvate and phenylpyruvate as its natural substrates. The definition of MIF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine.}},
  author       = {{Rosengren, Evald and Åman, Pierre and Thelin, Sofia and Hansson, Christer and Ahlfors, Stefan and Björk, Peter and Jacobsson, Lars and Rorsman, Hans}},
  issn         = {{1873-3468}},
  keywords     = {{Macrophage migration inhibitory factor; Phenylpyruvate tautomerase; Dopachrome tautomerase; Cytokine}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{85--88}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{FEBS Letters}},
  title        = {{The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase}},
  url          = {{http://dx.doi.org/10.1016/S0014-5793(97)01261-1}},
  doi          = {{10.1016/S0014-5793(97)01261-1}},
  volume       = {{417}},
  year         = {{1997}},
}