Relaxant effects of propofol on human omental arteries and veins
(1998) In British Journal of Anaesthesia 80(5). p.655-659- Abstract
- We have investigated the relaxant effects of propofol on smooth muscle tension in human omental arteries and veins to determine if endothelium-related mechanisms are involved. Isolated vessel segments were precontracted with endothelin-1 and propofol was added cumulatively (10(-7)-10(-4) mol litre-1). In both artery and vein segments, propofol induced relaxation, which was not dependent on an intact endothelium. Relaxation was reduced when the extracellular K+ concentration was increased and in the presence of tetraethylammonium chloride (TEA). In intact segments, N-nitro-L-arginine methyl ester (L-NAME), indomethacin, glibenclamide, 4-aminopyridine, clotrimazole and atropine did not affect the concentration-response curve of propofol.... (More)
- We have investigated the relaxant effects of propofol on smooth muscle tension in human omental arteries and veins to determine if endothelium-related mechanisms are involved. Isolated vessel segments were precontracted with endothelin-1 and propofol was added cumulatively (10(-7)-10(-4) mol litre-1). In both artery and vein segments, propofol induced relaxation, which was not dependent on an intact endothelium. Relaxation was reduced when the extracellular K+ concentration was increased and in the presence of tetraethylammonium chloride (TEA). In intact segments, N-nitro-L-arginine methyl ester (L-NAME), indomethacin, glibenclamide, 4-aminopyridine, clotrimazole and atropine did not affect the concentration-response curve of propofol. This indicates that propofol relaxes human omental arteries and veins in an endothelium independent manner, and that hyperpolarization caused by activation of the K+ channel, BKCa, may be involved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1112967
- author
- Wallerstedt, S M ; Tornebrandt, K and Bodelsson, Mikael LU
- organization
- publishing date
- 1998
- type
- Contribution to journal
- publication status
- published
- subject
- in
- British Journal of Anaesthesia
- volume
- 80
- issue
- 5
- pages
- 655 - 659
- publisher
- Elsevier
- external identifiers
-
- pmid:9691872
- scopus:2642624623
- ISSN
- 1471-6771
- language
- English
- LU publication?
- yes
- id
- 29cb8fda-efa6-4170-8920-da1326371051 (old id 1112967)
- alternative location
- http://bja.oxfordjournals.org/cgi/reprint/80/5/655
- date added to LUP
- 2016-04-01 11:48:33
- date last changed
- 2022-01-26 18:35:41
@article{29cb8fda-efa6-4170-8920-da1326371051,
abstract = {{We have investigated the relaxant effects of propofol on smooth muscle tension in human omental arteries and veins to determine if endothelium-related mechanisms are involved. Isolated vessel segments were precontracted with endothelin-1 and propofol was added cumulatively (10(-7)-10(-4) mol litre-1). In both artery and vein segments, propofol induced relaxation, which was not dependent on an intact endothelium. Relaxation was reduced when the extracellular K+ concentration was increased and in the presence of tetraethylammonium chloride (TEA). In intact segments, N-nitro-L-arginine methyl ester (L-NAME), indomethacin, glibenclamide, 4-aminopyridine, clotrimazole and atropine did not affect the concentration-response curve of propofol. This indicates that propofol relaxes human omental arteries and veins in an endothelium independent manner, and that hyperpolarization caused by activation of the K+ channel, BKCa, may be involved.}},
author = {{Wallerstedt, S M and Tornebrandt, K and Bodelsson, Mikael}},
issn = {{1471-6771}},
language = {{eng}},
number = {{5}},
pages = {{655--659}},
publisher = {{Elsevier}},
series = {{British Journal of Anaesthesia}},
title = {{Relaxant effects of propofol on human omental arteries and veins}},
url = {{http://bja.oxfordjournals.org/cgi/reprint/80/5/655}},
volume = {{80}},
year = {{1998}},
}