Protein H, an antiphagocytic surface protein in Streptococcus pyogenes
Kihlberg, B M ; Collin, Mattias LU
; Olsén, Arne
LU
and Björck, Lars
LU
(1999)
In Infection and Immunity
67(4).
p.1708-1714
- Abstract
- Surface-associated M protein is a major virulence factor in Streptococcus pyogenes which confers bacterial resistance to phagocytosis. However, many S. pyogenes strains also express additional structurally related so-called M-like proteins. The strain studied here is of the clinically important M1 serotype and expresses two structurally related surface proteins, the M1 protein and protein H. Mutants were generated that expressed only one or none of these proteins at the bacterial surface. For survival in human blood either protein H or M1 protein was sufficient, whereas the double mutant was rapidly killed. The protein-binding properties of protein H, M1 protein, and the mutants suggest that bacterial binding of immunoglobulin G and factor... (More)
- Surface-associated M protein is a major virulence factor in Streptococcus pyogenes which confers bacterial resistance to phagocytosis. However, many S. pyogenes strains also express additional structurally related so-called M-like proteins. The strain studied here is of the clinically important M1 serotype and expresses two structurally related surface proteins, the M1 protein and protein H. Mutants were generated that expressed only one or none of these proteins at the bacterial surface. For survival in human blood either protein H or M1 protein was sufficient, whereas the double mutant was rapidly killed. The protein-binding properties of protein H, M1 protein, and the mutants suggest that bacterial binding of immunoglobulin G and factor H or factor H-like protein 1, which are regulatory proteins in the complement system, contribute to the antiphagocytic property. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1114106
- author
- Kihlberg, B M
; Collin, Mattias
LU
; Olsén, Arne
LU
and Björck, Lars
LU
- organization
- publishing date
- 1999
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Infection and Immunity
- volume
- 67
- issue
- 4
- pages
- 1708 - 1714
- publisher
- American Society for Microbiology
- external identifiers
-
- pmid:10085008
- scopus:0033063964
- ISSN
- 1098-5522
- language
- English
- LU publication?
- yes
- id
- a26209b0-3cf6-41e7-a0ad-e062ce399cfc (old id 1114106)
- alternative location
- http://iai.asm.org/cgi/content/full/67/4/1708
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC96518/
- date added to LUP
- 2016-04-01 11:53:48
- date last changed
- 2022-01-26 19:48:24
@article{a26209b0-3cf6-41e7-a0ad-e062ce399cfc,
abstract = {{Surface-associated M protein is a major virulence factor in Streptococcus pyogenes which confers bacterial resistance to phagocytosis. However, many S. pyogenes strains also express additional structurally related so-called M-like proteins. The strain studied here is of the clinically important M1 serotype and expresses two structurally related surface proteins, the M1 protein and protein H. Mutants were generated that expressed only one or none of these proteins at the bacterial surface. For survival in human blood either protein H or M1 protein was sufficient, whereas the double mutant was rapidly killed. The protein-binding properties of protein H, M1 protein, and the mutants suggest that bacterial binding of immunoglobulin G and factor H or factor H-like protein 1, which are regulatory proteins in the complement system, contribute to the antiphagocytic property.}},
author = {{Kihlberg, B M and Collin, Mattias and Olsén, Arne and Björck, Lars}},
issn = {{1098-5522}},
language = {{eng}},
number = {{4}},
pages = {{1708--1714}},
publisher = {{American Society for Microbiology}},
series = {{Infection and Immunity}},
title = {{Protein H, an antiphagocytic surface protein in Streptococcus pyogenes}},
url = {{http://iai.asm.org/cgi/content/full/67/4/1708}},
volume = {{67}},
year = {{1999}},
}