Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein.
(2002) In Nature Reviews Neuroscience 3(12). p.932-942- Abstract
- Parkinson's disease is a devastating neurological condition that affects at least four million people. A striking feature of this disorder is the preferential loss of dopamine-producing neurons in the midbrain. Several aetiological triggers have been linked to Parkinson's disease, including genetic mutations and environmental toxins, but the pathway that leads to cell death is unknown. Recent developments have shed light on the pathogenic mechanisms that underlie the degeneration of these cells. We propose that defective sequestration of dopamine into vesicles, leading to the generation of reactive oxygen species in the cytoplasm, is a key event in the demise of dopaminergic neurons in Parkinson's disease, and might represent a common... (More)
- Parkinson's disease is a devastating neurological condition that affects at least four million people. A striking feature of this disorder is the preferential loss of dopamine-producing neurons in the midbrain. Several aetiological triggers have been linked to Parkinson's disease, including genetic mutations and environmental toxins, but the pathway that leads to cell death is unknown. Recent developments have shed light on the pathogenic mechanisms that underlie the degeneration of these cells. We propose that defective sequestration of dopamine into vesicles, leading to the generation of reactive oxygen species in the cytoplasm, is a key event in the demise of dopaminergic neurons in Parkinson's disease, and might represent a common pathway that underlies both genetic and sporadic forms of the disorder. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/111645
- author
- Lotharius, Julie LU and Brundin, Patrik LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Reviews Neuroscience
- volume
- 3
- issue
- 12
- pages
- 932 - 942
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000179600100012
- pmid:12461550
- scopus:0036884733
- ISSN
- 1471-003X
- DOI
- 10.1038/nrn983
- language
- English
- LU publication?
- yes
- id
- 331fbd01-d253-4e09-9ece-21660fb82e70 (old id 111645)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12461550&dopt=Abstract
- date added to LUP
- 2016-04-01 16:57:02
- date last changed
- 2022-04-23 01:21:52
@article{331fbd01-d253-4e09-9ece-21660fb82e70,
abstract = {{Parkinson's disease is a devastating neurological condition that affects at least four million people. A striking feature of this disorder is the preferential loss of dopamine-producing neurons in the midbrain. Several aetiological triggers have been linked to Parkinson's disease, including genetic mutations and environmental toxins, but the pathway that leads to cell death is unknown. Recent developments have shed light on the pathogenic mechanisms that underlie the degeneration of these cells. We propose that defective sequestration of dopamine into vesicles, leading to the generation of reactive oxygen species in the cytoplasm, is a key event in the demise of dopaminergic neurons in Parkinson's disease, and might represent a common pathway that underlies both genetic and sporadic forms of the disorder.}},
author = {{Lotharius, Julie and Brundin, Patrik}},
issn = {{1471-003X}},
language = {{eng}},
number = {{12}},
pages = {{932--942}},
publisher = {{Nature Publishing Group}},
series = {{Nature Reviews Neuroscience}},
title = {{Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein.}},
url = {{http://dx.doi.org/10.1038/nrn983}},
doi = {{10.1038/nrn983}},
volume = {{3}},
year = {{2002}},
}