Increased neurogenesis in a model of electroconvulsive therapy
(2000) In Biological Psychiatry 47(12). p.1043-1049- Abstract
- BACKGROUND: Electroconvulsive therapy (ECT) is a widely used and efficient treatment modality in psychiatry, although the basis for its therapeutic effect is still unknown. Past research has shown seizure activity to be a regulator of neurogenesis in the adult brain. This study examines the effect of a single and multiple electroconvulsive seizures on neurogenesis in the rat dentate gyrus. METHODS: Rats were given either a single or a series of 10 electroconvulsive seizures. At different times after the seizures, a marker of proliferating cells, Bromodeoxyuridine (BrdU), was administered to the animals. Subsequently, newborn cells positive for BrdU were counted in the dentate gyrus. Double staining with a neuron-specific marker indicated... (More)
- BACKGROUND: Electroconvulsive therapy (ECT) is a widely used and efficient treatment modality in psychiatry, although the basis for its therapeutic effect is still unknown. Past research has shown seizure activity to be a regulator of neurogenesis in the adult brain. This study examines the effect of a single and multiple electroconvulsive seizures on neurogenesis in the rat dentate gyrus. METHODS: Rats were given either a single or a series of 10 electroconvulsive seizures. At different times after the seizures, a marker of proliferating cells, Bromodeoxyuridine (BrdU), was administered to the animals. Subsequently, newborn cells positive for BrdU were counted in the dentate gyrus. Double staining with a neuron-specific marker indicated that the newborn cells displayed a neuronal phenotype. RESULTS: A single electroconvulsive seizure significantly increased the number of new born cells in the dentate gyrus. These cells survived for at least 3 months. A series of seizures further increased neurogenesis, indicating a dose-dependent mechanism. CONCLUSIONS: We propose that generation of new neurons in the hippocampus may be an important neurobiologic element underlying the clinical effects of electroconvulsive seizures. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1117617
- author
- Madsen, T M ; Treschow, Alexandra LU ; Bengzon, Johan LU ; Bolwig, T G ; Lindvall, Olle LU and Tingström, Anders LU
- organization
- publishing date
- 2000
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Biological Psychiatry
- volume
- 47
- issue
- 12
- pages
- 1043 - 1049
- publisher
- Elsevier
- external identifiers
-
- pmid:10862803
- scopus:0034040357
- ISSN
- 0006-3223
- DOI
- 10.1016/S0006-3223(00)00228-6
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Restorative Neurology (0131000160), Psychiatry (Lund) (013303000), Neurosurgery (013026000), Medical Inflammation Research (013212019)
- id
- b7b66705-8b6c-497a-a30b-15b9c13fda38 (old id 1117617)
- date added to LUP
- 2016-04-01 12:04:05
- date last changed
- 2022-04-05 17:06:13
@article{b7b66705-8b6c-497a-a30b-15b9c13fda38,
abstract = {{BACKGROUND: Electroconvulsive therapy (ECT) is a widely used and efficient treatment modality in psychiatry, although the basis for its therapeutic effect is still unknown. Past research has shown seizure activity to be a regulator of neurogenesis in the adult brain. This study examines the effect of a single and multiple electroconvulsive seizures on neurogenesis in the rat dentate gyrus. METHODS: Rats were given either a single or a series of 10 electroconvulsive seizures. At different times after the seizures, a marker of proliferating cells, Bromodeoxyuridine (BrdU), was administered to the animals. Subsequently, newborn cells positive for BrdU were counted in the dentate gyrus. Double staining with a neuron-specific marker indicated that the newborn cells displayed a neuronal phenotype. RESULTS: A single electroconvulsive seizure significantly increased the number of new born cells in the dentate gyrus. These cells survived for at least 3 months. A series of seizures further increased neurogenesis, indicating a dose-dependent mechanism. CONCLUSIONS: We propose that generation of new neurons in the hippocampus may be an important neurobiologic element underlying the clinical effects of electroconvulsive seizures.}},
author = {{Madsen, T M and Treschow, Alexandra and Bengzon, Johan and Bolwig, T G and Lindvall, Olle and Tingström, Anders}},
issn = {{0006-3223}},
language = {{eng}},
number = {{12}},
pages = {{1043--1049}},
publisher = {{Elsevier}},
series = {{Biological Psychiatry}},
title = {{Increased neurogenesis in a model of electroconvulsive therapy}},
url = {{http://dx.doi.org/10.1016/S0006-3223(00)00228-6}},
doi = {{10.1016/S0006-3223(00)00228-6}},
volume = {{47}},
year = {{2000}},
}