Serum IgE reactivity to Malassezia furfur extract and recombinant M-furfur allergens in patients with atopic dermatitis
(2001) In Acta Dermato-Venereologica 81(6). p.418-422- Abstract
- IgE reactivity to the opportunistic yeast Malassezia furfur can be found in patients with atopic dermatitis (AD). We have previously cloned and expressed 6 recombinant allergens (rMal f 1. rMal f 5-9) from M. furfur. In the present study, we used ImmunoCAP to investigate whether these rMal f allergens can be useful in the diagnosis of M. furfur-associated AD compared with the M. furfur extract. A total of 156 adult patients with a clinical diagnosis of AD participated in the study. Sixty-four percent had increased total serum IgE levels, 79% had specific IgE antibodies to common inhalant allergens and 47% had IgE antibodies to M. furfur extract. IgE antibodies to any of the rMal f allergens were detected among 86 (55%) of the patients, 14... (More)
- IgE reactivity to the opportunistic yeast Malassezia furfur can be found in patients with atopic dermatitis (AD). We have previously cloned and expressed 6 recombinant allergens (rMal f 1. rMal f 5-9) from M. furfur. In the present study, we used ImmunoCAP to investigate whether these rMal f allergens can be useful in the diagnosis of M. furfur-associated AD compared with the M. furfur extract. A total of 156 adult patients with a clinical diagnosis of AD participated in the study. Sixty-four percent had increased total serum IgE levels, 79% had specific IgE antibodies to common inhalant allergens and 47% had IgE antibodies to M. furfur extract. IgE antibodies to any of the rMal f allergens were detected among 86 (55%) of the patients, 14 (16%) of whom did not react to the M. furfur extract. Any individual rMal f allergen detected between 32% and 89% of the patients ImmunoCAP-positive to the M. fin fur extract, with the highest sensitivity for rMal f 9. Therefore, a couple of individual rMal f allergens can improve the diagnosis of M. furfur-associated I-E allergies in patients with AD. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1118473
- author
- Zargari, A. ; Eshaghi, H. ; Bäck, Ove LU ; Johansson, S. and Scheynius, A.
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Dermato-Venereologica
- volume
- 81
- issue
- 6
- pages
- 418 - 422
- publisher
- Medical Journals Limited
- external identifiers
-
- wos:000173698500009
- scopus:0035699353
- ISSN
- 1651-2057
- DOI
- 10.1080/000155501317208363
- language
- English
- LU publication?
- yes
- id
- 46b66748-f96e-49df-9ed3-b5c6e7792753 (old id 1118473)
- date added to LUP
- 2016-04-01 17:02:36
- date last changed
- 2022-01-28 23:55:39
@article{46b66748-f96e-49df-9ed3-b5c6e7792753, abstract = {{IgE reactivity to the opportunistic yeast Malassezia furfur can be found in patients with atopic dermatitis (AD). We have previously cloned and expressed 6 recombinant allergens (rMal f 1. rMal f 5-9) from M. furfur. In the present study, we used ImmunoCAP to investigate whether these rMal f allergens can be useful in the diagnosis of M. furfur-associated AD compared with the M. furfur extract. A total of 156 adult patients with a clinical diagnosis of AD participated in the study. Sixty-four percent had increased total serum IgE levels, 79% had specific IgE antibodies to common inhalant allergens and 47% had IgE antibodies to M. furfur extract. IgE antibodies to any of the rMal f allergens were detected among 86 (55%) of the patients, 14 (16%) of whom did not react to the M. furfur extract. Any individual rMal f allergen detected between 32% and 89% of the patients ImmunoCAP-positive to the M. fin fur extract, with the highest sensitivity for rMal f 9. Therefore, a couple of individual rMal f allergens can improve the diagnosis of M. furfur-associated I-E allergies in patients with AD.}}, author = {{Zargari, A. and Eshaghi, H. and Bäck, Ove and Johansson, S. and Scheynius, A.}}, issn = {{1651-2057}}, language = {{eng}}, number = {{6}}, pages = {{418--422}}, publisher = {{Medical Journals Limited}}, series = {{Acta Dermato-Venereologica}}, title = {{Serum IgE reactivity to Malassezia furfur extract and recombinant M-furfur allergens in patients with atopic dermatitis}}, url = {{http://dx.doi.org/10.1080/000155501317208363}}, doi = {{10.1080/000155501317208363}}, volume = {{81}}, year = {{2001}}, }