Regulation of human neutrophil granule protein expression
(2001) In Current Opinion in Hematology 8(1). p.23-27- Abstract
- The function of the mature polymorphonuclear neutrophil is dependent on its granules, each with its characteristic content of proteins. The granule proteins are formed at different stages during maturation of neutrophils from myeloblasts to segmented cells. The regulation of granule protein expression is controlled by a number of transcription factors, many of which are also essential for commitment of multipotent hematopoietic stem cells to lineage-committed myeloid progenitor cells and for differentiation of these progenitor cells; among these, PU.1 and C/EBPalpha stand out as critical for all granule proteins whereas AML-1 is critical for primary granule protein expression and C/EBPepsilon for secondary and tertiary granule protein... (More)
- The function of the mature polymorphonuclear neutrophil is dependent on its granules, each with its characteristic content of proteins. The granule proteins are formed at different stages during maturation of neutrophils from myeloblasts to segmented cells. The regulation of granule protein expression is controlled by a number of transcription factors, many of which are also essential for commitment of multipotent hematopoietic stem cells to lineage-committed myeloid progenitor cells and for differentiation of these progenitor cells; among these, PU.1 and C/EBPalpha stand out as critical for all granule proteins whereas AML-1 is critical for primary granule protein expression and C/EBPepsilon for secondary and tertiary granule protein expression. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1119957
- author
- Borregaard, N ; Theilgaard-Monch, K ; Sørensen, Ole E LU and Cowland, J B
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Current Opinion in Hematology
- volume
- 8
- issue
- 1
- pages
- 23 - 27
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:11138622
- scopus:0035171827
- ISSN
- 1531-7048
- language
- English
- LU publication?
- yes
- id
- 4ac7864c-bcb8-486e-a345-8a2444bffd7a (old id 1119957)
- date added to LUP
- 2016-04-01 15:17:40
- date last changed
- 2022-01-28 04:37:43
@article{4ac7864c-bcb8-486e-a345-8a2444bffd7a,
abstract = {{The function of the mature polymorphonuclear neutrophil is dependent on its granules, each with its characteristic content of proteins. The granule proteins are formed at different stages during maturation of neutrophils from myeloblasts to segmented cells. The regulation of granule protein expression is controlled by a number of transcription factors, many of which are also essential for commitment of multipotent hematopoietic stem cells to lineage-committed myeloid progenitor cells and for differentiation of these progenitor cells; among these, PU.1 and C/EBPalpha stand out as critical for all granule proteins whereas AML-1 is critical for primary granule protein expression and C/EBPepsilon for secondary and tertiary granule protein expression.}},
author = {{Borregaard, N and Theilgaard-Monch, K and Sørensen, Ole E and Cowland, J B}},
issn = {{1531-7048}},
language = {{eng}},
number = {{1}},
pages = {{23--27}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Current Opinion in Hematology}},
title = {{Regulation of human neutrophil granule protein expression}},
volume = {{8}},
year = {{2001}},
}