Relationship between abdominal fat compartments and glucose and lipid metabolism in early postmenopausal women
(2001) In Journal of Clinical Endocrinology and Metabolism 86(2). p.744-749- Abstract
- The relationships between abdominal and pelvic fat compartments and glucose and lipid metabolism were investigated in early postmenopausal women. Fifty-five healthy, postmenopausal women aged 52-53 yr participated in the study. Fat distribution (intra-abdominal and sc abdominal fat, and intrapelvic and sc pelvic fat) was estimated by computed tomography. Insulin sensitivity was assessed by euglycemic hyperinsulinemic clamp. In a multiple regression analysis, the size of the intra-abdominal fat compartment was the only significant predictor of insulin sensitivity (r(2) = 24%; P = 0.0002). Plasma triglycerides were closely related to the size of the intra-abdominal fat compartment (r(2) = 26%; P < 0.0001), whereas plasma free fatty acid... (More)
- The relationships between abdominal and pelvic fat compartments and glucose and lipid metabolism were investigated in early postmenopausal women. Fifty-five healthy, postmenopausal women aged 52-53 yr participated in the study. Fat distribution (intra-abdominal and sc abdominal fat, and intrapelvic and sc pelvic fat) was estimated by computed tomography. Insulin sensitivity was assessed by euglycemic hyperinsulinemic clamp. In a multiple regression analysis, the size of the intra-abdominal fat compartment was the only significant predictor of insulin sensitivity (r(2) = 24%; P = 0.0002). Plasma triglycerides were closely related to the size of the intra-abdominal fat compartment (r(2) = 26%; P < 0.0001), whereas plasma free fatty acid concentrations only correlated to the size of the sc abdominal fat compartment (r(2) = 18.5%, P = 0.001). In early postmenopausal women the amount of the intra-abdominal fat strongly influences insulin sensitivity and plasma triglyceride levels, whereas plasma free fatty acids are closely related to the amount of the sc abdominal fat. Accordingly, from a metabolic standpoint it seems most essential to reduce intra-abdominal fat in postmenopausal women. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1120215
- author
- Rendell, M ; Hulthen, U L ; Törnquist, C ; Groop, Leif LU and Mattiasson, Ingrid LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Clinical Endocrinology and Metabolism
- volume
- 86
- issue
- 2
- pages
- 744 - 749
- publisher
- Oxford University Press
- external identifiers
-
- pmid:11158040
- scopus:0035090380
- ISSN
- 1945-7197
- language
- English
- LU publication?
- yes
- id
- c6f4bc61-e31e-4baa-89cd-e5430d44f48a (old id 1120215)
- alternative location
- http://jcem.endojournals.org/cgi/content/full/86/2/744
- date added to LUP
- 2016-04-01 16:59:33
- date last changed
- 2024-01-11 18:38:43
@article{c6f4bc61-e31e-4baa-89cd-e5430d44f48a,
abstract = {{The relationships between abdominal and pelvic fat compartments and glucose and lipid metabolism were investigated in early postmenopausal women. Fifty-five healthy, postmenopausal women aged 52-53 yr participated in the study. Fat distribution (intra-abdominal and sc abdominal fat, and intrapelvic and sc pelvic fat) was estimated by computed tomography. Insulin sensitivity was assessed by euglycemic hyperinsulinemic clamp. In a multiple regression analysis, the size of the intra-abdominal fat compartment was the only significant predictor of insulin sensitivity (r(2) = 24%; P = 0.0002). Plasma triglycerides were closely related to the size of the intra-abdominal fat compartment (r(2) = 26%; P < 0.0001), whereas plasma free fatty acid concentrations only correlated to the size of the sc abdominal fat compartment (r(2) = 18.5%, P = 0.001). In early postmenopausal women the amount of the intra-abdominal fat strongly influences insulin sensitivity and plasma triglyceride levels, whereas plasma free fatty acids are closely related to the amount of the sc abdominal fat. Accordingly, from a metabolic standpoint it seems most essential to reduce intra-abdominal fat in postmenopausal women.}},
author = {{Rendell, M and Hulthen, U L and Törnquist, C and Groop, Leif and Mattiasson, Ingrid}},
issn = {{1945-7197}},
language = {{eng}},
number = {{2}},
pages = {{744--749}},
publisher = {{Oxford University Press}},
series = {{Journal of Clinical Endocrinology and Metabolism}},
title = {{Relationship between abdominal fat compartments and glucose and lipid metabolism in early postmenopausal women}},
url = {{http://jcem.endojournals.org/cgi/content/full/86/2/744}},
volume = {{86}},
year = {{2001}},
}