Histopathological and cell biological factors of ductal carcinoma in situ before and after the introduction of mammographic screening
Idvall, Ingrid LU ; Andersson, Christina ; Fallenius, Ghita ; Ingvar, Christian LU ; Ringberg, Anita LU ; Forsare, Carina LU
; Åkerman, Måns
LU
and Fernö, Mårten
LU
(2001)
In Acta Oncologica
40(5).
p.653-659
- Abstract
- With the introduction of mammographic screening the incidence of ductal carcinoma in situ (DCIS) has increased to 10-15% of all breast cancers. The aim of this study was to investigate whether there were any morphological and cell biological differences between DCIS detected during the pre-screening (n = 39) as opposed to the screening period (n = 120). We could not demonstrate any statistically significant differences between the pre-screening and the screening period with regard to nuclear grade, presence of necrosis, the Van Nuys classification system, growth pattern, or cell biological factors (estrogen and progesterone receptors, c-erbB-2, p53, DNA ploidy status, Ki67, and Auer classes). These findings suggest that DCIS tumors... (More)
- With the introduction of mammographic screening the incidence of ductal carcinoma in situ (DCIS) has increased to 10-15% of all breast cancers. The aim of this study was to investigate whether there were any morphological and cell biological differences between DCIS detected during the pre-screening (n = 39) as opposed to the screening period (n = 120). We could not demonstrate any statistically significant differences between the pre-screening and the screening period with regard to nuclear grade, presence of necrosis, the Van Nuys classification system, growth pattern, or cell biological factors (estrogen and progesterone receptors, c-erbB-2, p53, DNA ploidy status, Ki67, and Auer classes). These findings suggest that DCIS tumors detected during the two time periods have a similar malignant potential. DCIS detected during the screening period was further divided into the prevalence period versus the period thereafter, and symptomatic versus screening-detected asymptomatic cases. More cases with diffuse growth patterns were seen during the prevalence period than after the prevalence period, and screening-detected asymptomatic DCISs were more often 15 mm or smaller in diameter than DCISs detected symptomatically. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1120741
- author
- Idvall, Ingrid
LU
; Andersson, Christina
; Fallenius, Ghita
; Ingvar, Christian
LU
; Ringberg, Anita
LU
; Forsare, Carina
LU
; Åkerman, Måns
LU
and Fernö, Mårten
LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Oncologica
- volume
- 40
- issue
- 5
- pages
- 653 - 659
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:11669340
- scopus:0034794724
- ISSN
- 1651-226X
- DOI
- 10.1080/028418601750444222
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Surgery Research Unit (013242220), Surgery (Lund) (013009000), Oncology, MV (013035000)
- id
- 0b85da27-673d-44d4-8f97-1f36d4a34dc7 (old id 1120741)
- date added to LUP
- 2016-04-01 16:19:35
- date last changed
- 2022-01-28 18:55:51
@article{0b85da27-673d-44d4-8f97-1f36d4a34dc7,
abstract = {{With the introduction of mammographic screening the incidence of ductal carcinoma in situ (DCIS) has increased to 10-15% of all breast cancers. The aim of this study was to investigate whether there were any morphological and cell biological differences between DCIS detected during the pre-screening (n = 39) as opposed to the screening period (n = 120). We could not demonstrate any statistically significant differences between the pre-screening and the screening period with regard to nuclear grade, presence of necrosis, the Van Nuys classification system, growth pattern, or cell biological factors (estrogen and progesterone receptors, c-erbB-2, p53, DNA ploidy status, Ki67, and Auer classes). These findings suggest that DCIS tumors detected during the two time periods have a similar malignant potential. DCIS detected during the screening period was further divided into the prevalence period versus the period thereafter, and symptomatic versus screening-detected asymptomatic cases. More cases with diffuse growth patterns were seen during the prevalence period than after the prevalence period, and screening-detected asymptomatic DCISs were more often 15 mm or smaller in diameter than DCISs detected symptomatically.}},
author = {{Idvall, Ingrid and Andersson, Christina and Fallenius, Ghita and Ingvar, Christian and Ringberg, Anita and Forsare, Carina and Åkerman, Måns and Fernö, Mårten}},
issn = {{1651-226X}},
language = {{eng}},
number = {{5}},
pages = {{653--659}},
publisher = {{Taylor & Francis}},
series = {{Acta Oncologica}},
title = {{Histopathological and cell biological factors of ductal carcinoma in situ before and after the introduction of mammographic screening}},
url = {{http://dx.doi.org/10.1080/028418601750444222}},
doi = {{10.1080/028418601750444222}},
volume = {{40}},
year = {{2001}},
}