Early, selective, and marked loss of sympathetic nerves from the islets of BioBreeder diabetic rats.
Mei, Q ; Mundinger, TO ; Lernmark, Åke LU
and Taborsky, GJ Jr.
(2002)
In Diabetes
51(10).
p.2997-3002
- Abstract
- To discover whether islet sympathetic nerves are damaged during the autoimmune destruction of islet B-cells, we immunostained sections of pancreas from BioBreeder (BB) diabetic rats, using antibodies against vesicular monoamine transporter 2 (VMAT2), a marker of sympathetic nerve terminals. We found a marked decrease in the VMAT2-positive fiber area in the islets of BB rats that had been diabetic for only 1-2 weeks compared with their nondiabetic controls. In contrast, there was no significant decrease in the VMAT2-positive fiber area in the exocrine pancreas in these early diabetic BB rats. Furthermore, streptozotocin-diabetic rats showed no decrease in VMAT2-positive fiber area in their islets compared with controls. The classical... (More)
- To discover whether islet sympathetic nerves are damaged during the autoimmune destruction of islet B-cells, we immunostained sections of pancreas from BioBreeder (BB) diabetic rats, using antibodies against vesicular monoamine transporter 2 (VMAT2), a marker of sympathetic nerve terminals. We found a marked decrease in the VMAT2-positive fiber area in the islets of BB rats that had been diabetic for only 1-2 weeks compared with their nondiabetic controls. In contrast, there was no significant decrease in the VMAT2-positive fiber area in the exocrine pancreas in these early diabetic BB rats. Furthermore, streptozotocin-diabetic rats showed no decrease in VMAT2-positive fiber area in their islets compared with controls. The classical diabetic autonomic neuropathy (DAN) that eventually occurs in the heart was not present in BB diabetic rats at this early stage as evidenced by normal cardiac VMAT2 immunostaining and normal cardiac norepinephrine content. Also, in contrast to DAN, this isl (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1124793
- author
- Mei, Q
; Mundinger, TO
; Lernmark, Åke
LU
and Taborsky, GJ Jr.
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes
- volume
- 51
- issue
- 10
- pages
- 2997 - 3002
- publisher
- American Diabetes Association Inc.
- external identifiers
-
- scopus:0036789177
- ISSN
- 1939-327X
- DOI
- 10.2337/diabetes.51.10.2997
- language
- English
- LU publication?
- no
- id
- 1da4aebc-65a5-4bc8-b54c-f25295794d37 (old id 1124793)
- alternative location
- http://diabetes.diabetesjournals.org/cgi/content/abstract/51/10/2997
- date added to LUP
- 2016-04-01 11:37:59
- date last changed
- 2022-04-20 19:30:25
@article{1da4aebc-65a5-4bc8-b54c-f25295794d37,
abstract = {{To discover whether islet sympathetic nerves are damaged during the autoimmune destruction of islet B-cells, we immunostained sections of pancreas from BioBreeder (BB) diabetic rats, using antibodies against vesicular monoamine transporter 2 (VMAT2), a marker of sympathetic nerve terminals. We found a marked decrease in the VMAT2-positive fiber area in the islets of BB rats that had been diabetic for only 1-2 weeks compared with their nondiabetic controls. In contrast, there was no significant decrease in the VMAT2-positive fiber area in the exocrine pancreas in these early diabetic BB rats. Furthermore, streptozotocin-diabetic rats showed no decrease in VMAT2-positive fiber area in their islets compared with controls. The classical diabetic autonomic neuropathy (DAN) that eventually occurs in the heart was not present in BB diabetic rats at this early stage as evidenced by normal cardiac VMAT2 immunostaining and normal cardiac norepinephrine content. Also, in contrast to DAN, this isl}},
author = {{Mei, Q and Mundinger, TO and Lernmark, Åke and Taborsky, GJ Jr.}},
issn = {{1939-327X}},
language = {{eng}},
number = {{10}},
pages = {{2997--3002}},
publisher = {{American Diabetes Association Inc.}},
series = {{Diabetes}},
title = {{Early, selective, and marked loss of sympathetic nerves from the islets of BioBreeder diabetic rats.}},
url = {{http://dx.doi.org/10.2337/diabetes.51.10.2997}},
doi = {{10.2337/diabetes.51.10.2997}},
volume = {{51}},
year = {{2002}},
}