PPAR expression and function during vertebrate development
(2002) In International Journal of Developmental Biology 46(1). p.105-114- Abstract
- The peroxisome proliferator activated receptors (PPARs) are ligand activated receptors which belong to the nuclear hormone receptor family. As with other members of this superfamily, it is thought that the ability of PPAR to bind to a ligand was acquired during metazoan evolution. Three different PPAR isotypes (PPARalpha, PPARbeta, also called 6, and PPARgamma) have been identified in various species. Upon binding to an activator, these receptors stimulate the expression of target genes implicated in important metabolic pathways. The present article is a review of PPAR expression and involvement in some aspects of Xenopus laevis and rodent embryonic development. PPARalpha and beta are ubiquitously expressed in Xenopus early embryos but... (More)
- The peroxisome proliferator activated receptors (PPARs) are ligand activated receptors which belong to the nuclear hormone receptor family. As with other members of this superfamily, it is thought that the ability of PPAR to bind to a ligand was acquired during metazoan evolution. Three different PPAR isotypes (PPARalpha, PPARbeta, also called 6, and PPARgamma) have been identified in various species. Upon binding to an activator, these receptors stimulate the expression of target genes implicated in important metabolic pathways. The present article is a review of PPAR expression and involvement in some aspects of Xenopus laevis and rodent embryonic development. PPARalpha and beta are ubiquitously expressed in Xenopus early embryos but become more tissue restricted later in development. In rodents, PPARalpha, PPARbeta and PPARgamma show specific time- and tissue-dependent patterns of expression during fetal development and in the adult animals. PPARs are implicated in several aspects of tissue differentiation and rodent development, such as differentiation of the adipose tissue, brain, placenta and skin. Particular attention is given to studies undertaken by us and others on the implication of PPARalpha and beta in rodent epidermal differentiation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1125417
- author
- Michalik, Liliane ; Desvergne, Beatrice ; Dreyer, Christine ; Gavillet, Mathilde ; Laurini, Ricardo LU and Wahli, Walter
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Developmental Biology
- volume
- 46
- issue
- 1
- pages
- 105 - 114
- publisher
- U B C Press
- external identifiers
-
- pmid:11902671
- scopus:0036005782
- ISSN
- 1696-3547
- language
- English
- LU publication?
- no
- id
- c07aac8d-0f89-43c7-ab45-7cbf8a495927 (old id 1125417)
- alternative location
- http://www.ijdb.ehu.es/web/paper.php?doi=11902671
- date added to LUP
- 2016-04-01 12:12:38
- date last changed
- 2022-04-05 19:11:47
@article{c07aac8d-0f89-43c7-ab45-7cbf8a495927, abstract = {{The peroxisome proliferator activated receptors (PPARs) are ligand activated receptors which belong to the nuclear hormone receptor family. As with other members of this superfamily, it is thought that the ability of PPAR to bind to a ligand was acquired during metazoan evolution. Three different PPAR isotypes (PPARalpha, PPARbeta, also called 6, and PPARgamma) have been identified in various species. Upon binding to an activator, these receptors stimulate the expression of target genes implicated in important metabolic pathways. The present article is a review of PPAR expression and involvement in some aspects of Xenopus laevis and rodent embryonic development. PPARalpha and beta are ubiquitously expressed in Xenopus early embryos but become more tissue restricted later in development. In rodents, PPARalpha, PPARbeta and PPARgamma show specific time- and tissue-dependent patterns of expression during fetal development and in the adult animals. PPARs are implicated in several aspects of tissue differentiation and rodent development, such as differentiation of the adipose tissue, brain, placenta and skin. Particular attention is given to studies undertaken by us and others on the implication of PPARalpha and beta in rodent epidermal differentiation.}}, author = {{Michalik, Liliane and Desvergne, Beatrice and Dreyer, Christine and Gavillet, Mathilde and Laurini, Ricardo and Wahli, Walter}}, issn = {{1696-3547}}, language = {{eng}}, number = {{1}}, pages = {{105--114}}, publisher = {{U B C Press}}, series = {{International Journal of Developmental Biology}}, title = {{PPAR expression and function during vertebrate development}}, url = {{http://www.ijdb.ehu.es/web/paper.php?doi=11902671}}, volume = {{46}}, year = {{2002}}, }