CD46 in meningococcal disease
(2003) In Science (New York, N.Y.) 301(5631). p.373-375- Abstract
- The human-specific bacterial pathogen Neisseria meningitidis is a major cause of sepsis and/or meningitis. The pili of N. meningitidis interact with CD46, a human cell-surface protein involved in regulation of complement activation. Transgenic mice expressing human CD46 were susceptible to meningococcal disease, because bacteria crossed the blood-brain barrier in these mice. Development of disease was more efficient with piliated bacteria after intranasal, but not intraperitoneal, challenge of CD46 transgenic mice, suggesting that human CD46 facilitates pilus-dependent interactions at the epithelial mucosa. Hence, the human CD46 transgenic mice model is a potentially useful tool for studying pathogenesis and for vaccine development against... (More)
- The human-specific bacterial pathogen Neisseria meningitidis is a major cause of sepsis and/or meningitis. The pili of N. meningitidis interact with CD46, a human cell-surface protein involved in regulation of complement activation. Transgenic mice expressing human CD46 were susceptible to meningococcal disease, because bacteria crossed the blood-brain barrier in these mice. Development of disease was more efficient with piliated bacteria after intranasal, but not intraperitoneal, challenge of CD46 transgenic mice, suggesting that human CD46 facilitates pilus-dependent interactions at the epithelial mucosa. Hence, the human CD46 transgenic mice model is a potentially useful tool for studying pathogenesis and for vaccine development against meningococcal disease. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1126309
- author
- Johansson, Linda ; Rytkonen, Anne ; Bergman, Peter ; Albiger, Barbara LU ; Kallstrom, Helena ; Hokfelt, Tomas ; Agerberth, Birgitta ; Cattaneo, Roberto and Jonsson, Ann-Beth
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Science (New York, N.Y.)
- volume
- 301
- issue
- 5631
- pages
- 373 - 375
- publisher
- American Association for the Advancement of Science (AAAS)
- external identifiers
-
- pmid:12869763
- scopus:0038638484
- pmid:12869763
- ISSN
- 1095-9203
- DOI
- 10.1126/science.1086476
- language
- English
- LU publication?
- no
- id
- db529046-558f-4630-b11b-07fc3b41b27b (old id 1126309)
- date added to LUP
- 2016-04-01 16:36:41
- date last changed
- 2022-01-28 20:55:50
@article{db529046-558f-4630-b11b-07fc3b41b27b,
abstract = {{The human-specific bacterial pathogen Neisseria meningitidis is a major cause of sepsis and/or meningitis. The pili of N. meningitidis interact with CD46, a human cell-surface protein involved in regulation of complement activation. Transgenic mice expressing human CD46 were susceptible to meningococcal disease, because bacteria crossed the blood-brain barrier in these mice. Development of disease was more efficient with piliated bacteria after intranasal, but not intraperitoneal, challenge of CD46 transgenic mice, suggesting that human CD46 facilitates pilus-dependent interactions at the epithelial mucosa. Hence, the human CD46 transgenic mice model is a potentially useful tool for studying pathogenesis and for vaccine development against meningococcal disease.}},
author = {{Johansson, Linda and Rytkonen, Anne and Bergman, Peter and Albiger, Barbara and Kallstrom, Helena and Hokfelt, Tomas and Agerberth, Birgitta and Cattaneo, Roberto and Jonsson, Ann-Beth}},
issn = {{1095-9203}},
language = {{eng}},
number = {{5631}},
pages = {{373--375}},
publisher = {{American Association for the Advancement of Science (AAAS)}},
series = {{Science (New York, N.Y.)}},
title = {{CD46 in meningococcal disease}},
url = {{http://dx.doi.org/10.1126/science.1086476}},
doi = {{10.1126/science.1086476}},
volume = {{301}},
year = {{2003}},
}