Expression of mouse Tbx22 supports its role in palatogenesis and glossogenesis
(2003) In Developmental Dynamics 226(4). p.579-586- Abstract
- TBX22 belongs to the T-box family of transcription factors and was originally found in an in silico approach designed to identify new genes on the human Xq12-q21 region. Mutations in TBX22 have been reported in families with X-linked cleft palate and ankyloglossia (CPX), but the underlying pathogenetic mechanism remained unknown. We have identified mouse Tbx22 and analyzed its expression during embryogenesis by reverse transcriptase-polymerase chain reaction and in situ hybridization. In mouse embryos, it is expressed in distinct areas of the head, namely the mesenchyme of the inferior nasal septum, the posterior palatal shelf before fusion, the attachment of the tongue, and mesenchymal cells surrounding the eye anlage. The localization in... (More)
- TBX22 belongs to the T-box family of transcription factors and was originally found in an in silico approach designed to identify new genes on the human Xq12-q21 region. Mutations in TBX22 have been reported in families with X-linked cleft palate and ankyloglossia (CPX), but the underlying pathogenetic mechanism remained unknown. We have identified mouse Tbx22 and analyzed its expression during embryogenesis by reverse transcriptase-polymerase chain reaction and in situ hybridization. In mouse embryos, it is expressed in distinct areas of the head, namely the mesenchyme of the inferior nasal septum, the posterior palatal shelf before fusion, the attachment of the tongue, and mesenchymal cells surrounding the eye anlage. The localization in the tongue frenulum perfectly correlates with the ankyloglossia phenotype in CPX. Furthermore, we identified positionally conserved binding sites for transcription factors, two of which have been implicated previously in palatogenesis (MSX1, PRX2). (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1128138
- author
- Herr, Alexander ; Meunier, Dominique ; Muller, Ines ; Rump, Andreas ; Fundele, Reinald ; Ropers, H-Hilger and Nuber, Ulrike LU
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Developmental Dynamics
- volume
- 226
- issue
- 4
- pages
- 579 - 586
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:12666195
- scopus:0037382630
- pmid:12666195
- ISSN
- 1097-0177
- DOI
- 10.1002/dvdy.10260
- language
- English
- LU publication?
- no
- id
- 8206cfb6-bb3d-4faf-b49a-84af728ea0bd (old id 1128138)
- date added to LUP
- 2016-04-01 11:41:27
- date last changed
- 2022-01-26 08:50:24
@article{8206cfb6-bb3d-4faf-b49a-84af728ea0bd,
abstract = {{TBX22 belongs to the T-box family of transcription factors and was originally found in an in silico approach designed to identify new genes on the human Xq12-q21 region. Mutations in TBX22 have been reported in families with X-linked cleft palate and ankyloglossia (CPX), but the underlying pathogenetic mechanism remained unknown. We have identified mouse Tbx22 and analyzed its expression during embryogenesis by reverse transcriptase-polymerase chain reaction and in situ hybridization. In mouse embryos, it is expressed in distinct areas of the head, namely the mesenchyme of the inferior nasal septum, the posterior palatal shelf before fusion, the attachment of the tongue, and mesenchymal cells surrounding the eye anlage. The localization in the tongue frenulum perfectly correlates with the ankyloglossia phenotype in CPX. Furthermore, we identified positionally conserved binding sites for transcription factors, two of which have been implicated previously in palatogenesis (MSX1, PRX2).}},
author = {{Herr, Alexander and Meunier, Dominique and Muller, Ines and Rump, Andreas and Fundele, Reinald and Ropers, H-Hilger and Nuber, Ulrike}},
issn = {{1097-0177}},
language = {{eng}},
number = {{4}},
pages = {{579--586}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Developmental Dynamics}},
title = {{Expression of mouse Tbx22 supports its role in palatogenesis and glossogenesis}},
url = {{http://dx.doi.org/10.1002/dvdy.10260}},
doi = {{10.1002/dvdy.10260}},
volume = {{226}},
year = {{2003}},
}