Prognosis of asymptomatic stenosis of the middle cerebral artery
(2004) In Journal of Neurology, Neurosurgery and Psychiatry 75(9). p.1300-1303- Abstract
- BACKGROUND: The risk of ischaemic events in asymptomatic intracranial atherosclerosis is unknown. OBJECTIVE: To follow up patients with asymptomatic atherosclerotic middle cerebral artery stenosis (MCAS) to evaluate the long term stroke risk in its territory. METHODS: Consecutive white patients with asymptomatic atherosclerotic MCAS were enrolled. Patients with MCAS of possible or proven non-atherosclerotic origin were excluded. MCAS was assessed by transcranial colour duplex sonography according to published angiography validated criteria. Medical treatment was given at the discretion of the treating physician. RESULTS: 50 patients were included and followed for (mean (SD)) 815 (351) days; three were lost to follow up. MCAS was < 50%... (More)
- BACKGROUND: The risk of ischaemic events in asymptomatic intracranial atherosclerosis is unknown. OBJECTIVE: To follow up patients with asymptomatic atherosclerotic middle cerebral artery stenosis (MCAS) to evaluate the long term stroke risk in its territory. METHODS: Consecutive white patients with asymptomatic atherosclerotic MCAS were enrolled. Patients with MCAS of possible or proven non-atherosclerotic origin were excluded. MCAS was assessed by transcranial colour duplex sonography according to published angiography validated criteria. Medical treatment was given at the discretion of the treating physician. RESULTS: 50 patients were included and followed for (mean (SD)) 815 (351) days; three were lost to follow up. MCAS was < 50% in 38 and > or = 50% in 12. No patient suffered an ischaemic event in the MCAS territory; one had a transient ischaemic attack in the contralateral hemisphere. Three patients died, one from a subdural haematoma in the contralateral hemisphere, and two from non-stroke-related causes. Medical treatment at baseline included antithrombotic drugs in 42 cases (antiplatelet agent, n = 39; warfarin, n = 3), and statins in 22; at the end of follow up 45 of the 47 survivors were on antithrombotic drugs (antiplatelet agent, n = 37; warfarin, n = 8), and 30 were on statins. CONCLUSIONS: Asymptomatic MCAS of atherosclerotic origin appears to have a benign long term prognosis with a low risk of ipsilateral stroke in medically treated white patients. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1130890
- author
- Kremer, Christine LU ; Schaettin, T ; Georgiadis, D and Baumgartner, R W
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Neurology, Neurosurgery and Psychiatry
- volume
- 75
- issue
- 9
- pages
- 1300 - 1303
- publisher
- BMJ Publishing Group
- external identifiers
-
- pmid:15314120
- scopus:4344601559
- ISSN
- 1468-330X
- DOI
- 10.1136/jnnp.2003.017863
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neurology, Malmö (013027010)
- id
- d2e0e8e7-9dad-43ba-b098-86726d271716 (old id 1130890)
- date added to LUP
- 2016-04-01 17:00:46
- date last changed
- 2022-01-28 23:44:45
@article{d2e0e8e7-9dad-43ba-b098-86726d271716, abstract = {{BACKGROUND: The risk of ischaemic events in asymptomatic intracranial atherosclerosis is unknown. OBJECTIVE: To follow up patients with asymptomatic atherosclerotic middle cerebral artery stenosis (MCAS) to evaluate the long term stroke risk in its territory. METHODS: Consecutive white patients with asymptomatic atherosclerotic MCAS were enrolled. Patients with MCAS of possible or proven non-atherosclerotic origin were excluded. MCAS was assessed by transcranial colour duplex sonography according to published angiography validated criteria. Medical treatment was given at the discretion of the treating physician. RESULTS: 50 patients were included and followed for (mean (SD)) 815 (351) days; three were lost to follow up. MCAS was < 50% in 38 and > or = 50% in 12. No patient suffered an ischaemic event in the MCAS territory; one had a transient ischaemic attack in the contralateral hemisphere. Three patients died, one from a subdural haematoma in the contralateral hemisphere, and two from non-stroke-related causes. Medical treatment at baseline included antithrombotic drugs in 42 cases (antiplatelet agent, n = 39; warfarin, n = 3), and statins in 22; at the end of follow up 45 of the 47 survivors were on antithrombotic drugs (antiplatelet agent, n = 37; warfarin, n = 8), and 30 were on statins. CONCLUSIONS: Asymptomatic MCAS of atherosclerotic origin appears to have a benign long term prognosis with a low risk of ipsilateral stroke in medically treated white patients.}}, author = {{Kremer, Christine and Schaettin, T and Georgiadis, D and Baumgartner, R W}}, issn = {{1468-330X}}, language = {{eng}}, number = {{9}}, pages = {{1300--1303}}, publisher = {{BMJ Publishing Group}}, series = {{Journal of Neurology, Neurosurgery and Psychiatry}}, title = {{Prognosis of asymptomatic stenosis of the middle cerebral artery}}, url = {{http://dx.doi.org/10.1136/jnnp.2003.017863}}, doi = {{10.1136/jnnp.2003.017863}}, volume = {{75}}, year = {{2004}}, }