Assessment of in vivo MR imaging compared to physical sections in vitro--a quantitative study of brain volumes using stereology
Jelsing, Jacob ; Rostrup, Egill ; Markenroth Bloch, Karin LU
; Paulson, Olaf B
; Gundersen, Hans Jorgen G
; Hemmingsen, Ralf
and Pakkenberg, Bente
(2005)
In NeuroImage
26(1).
p.57-65
- Abstract
- The object of the present study was to compare stereological estimates of brain volumes obtained in vivo by magnetic resonance imaging (MRI) to corresponding volumes from physical sections in vitro. Brains of ten domestic pigs were imaged using a 3-T scanner. The volumes of different brain compartments were obtained from MR images by two observers and from physical sections using the Cavalieri estimator in combination with point counting. Paired t tests revealed no significant differences between the two methods for any of the five compartments considered, except for the basal gray compartment. However, although intraobserver difference of MRI estimates was acceptable, the interobserver difference was not. A statistical highly significant... (More)
- The object of the present study was to compare stereological estimates of brain volumes obtained in vivo by magnetic resonance imaging (MRI) to corresponding volumes from physical sections in vitro. Brains of ten domestic pigs were imaged using a 3-T scanner. The volumes of different brain compartments were obtained from MR images by two observers and from physical sections using the Cavalieri estimator in combination with point counting. Paired t tests revealed no significant differences between the two methods for any of the five compartments considered, except for the basal gray compartment. However, although intraobserver difference of MRI estimates was acceptable, the interobserver difference was not. A statistical highly significant difference of 11-41% was observed between observers for volume estimates of all compartments considered. The study demonstrates that quantitative MRI is susceptible to observer dependent interpretation of images. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1132989
- author
- Jelsing, Jacob
; Rostrup, Egill
; Markenroth Bloch, Karin
LU
; Paulson, Olaf B
; Gundersen, Hans Jorgen G
; Hemmingsen, Ralf
and Pakkenberg, Bente
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- in
- NeuroImage
- volume
- 26
- issue
- 1
- pages
- 57 - 65
- publisher
- Elsevier
- external identifiers
-
- pmid:15862205
- scopus:18044368271
- ISSN
- 1095-9572
- DOI
- 10.1016/j.neuroimage.2005.01.005
- language
- English
- LU publication?
- no
- id
- bd73f643-13ff-4800-83c9-2c2d9915536c (old id 1132989)
- date added to LUP
- 2016-04-01 11:42:44
- date last changed
- 2022-01-26 17:06:30
@article{bd73f643-13ff-4800-83c9-2c2d9915536c,
abstract = {{The object of the present study was to compare stereological estimates of brain volumes obtained in vivo by magnetic resonance imaging (MRI) to corresponding volumes from physical sections in vitro. Brains of ten domestic pigs were imaged using a 3-T scanner. The volumes of different brain compartments were obtained from MR images by two observers and from physical sections using the Cavalieri estimator in combination with point counting. Paired t tests revealed no significant differences between the two methods for any of the five compartments considered, except for the basal gray compartment. However, although intraobserver difference of MRI estimates was acceptable, the interobserver difference was not. A statistical highly significant difference of 11-41% was observed between observers for volume estimates of all compartments considered. The study demonstrates that quantitative MRI is susceptible to observer dependent interpretation of images.}},
author = {{Jelsing, Jacob and Rostrup, Egill and Markenroth Bloch, Karin and Paulson, Olaf B and Gundersen, Hans Jorgen G and Hemmingsen, Ralf and Pakkenberg, Bente}},
issn = {{1095-9572}},
language = {{eng}},
number = {{1}},
pages = {{57--65}},
publisher = {{Elsevier}},
series = {{NeuroImage}},
title = {{Assessment of in vivo MR imaging compared to physical sections in vitro--a quantitative study of brain volumes using stereology}},
url = {{http://dx.doi.org/10.1016/j.neuroimage.2005.01.005}},
doi = {{10.1016/j.neuroimage.2005.01.005}},
volume = {{26}},
year = {{2005}},
}