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Evidens för trombosprofylax till medicinpatienter med hög risk

Själander, Anders ; Jansson, Jan-Åke ; Bergqvist, David ; Eriksson, Henry and Svensson, Peter LU (2007) In Läkartidningen 104(20-21). p.1585-1587
Abstract
Venous thromboembolism (VTE) is a common complication of hospitalization, and can result in substantial morbidity and treatment cost. In orthopedic and general surgery, it is common practice to use low-molecular-weight heparin as a thromboprophylaxis. For medical patients, however, the issue of prophylaxis remains under debate. Data from three recent large randomized studies of medical patients at risk for VTE: PREVENT, MEDENOX and ARTEMIS, were combined. They showed an absolute risk reduction (ARR) for symptomatic VTE of 0,48 percent, asymptomatic VTE of 2,5 percent with a subsequent increase in major bleedings of 0,38 percent. In most studies, low-molecular-weight heparin reduces the risk of VTE by approximately 45 percent. Thus, the... (More)
Venous thromboembolism (VTE) is a common complication of hospitalization, and can result in substantial morbidity and treatment cost. In orthopedic and general surgery, it is common practice to use low-molecular-weight heparin as a thromboprophylaxis. For medical patients, however, the issue of prophylaxis remains under debate. Data from three recent large randomized studies of medical patients at risk for VTE: PREVENT, MEDENOX and ARTEMIS, were combined. They showed an absolute risk reduction (ARR) for symptomatic VTE of 0,48 percent, asymptomatic VTE of 2,5 percent with a subsequent increase in major bleedings of 0,38 percent. In most studies, low-molecular-weight heparin reduces the risk of VTE by approximately 45 percent. Thus, the prophylaxis may be efficient, but its clinical use is limited to patient populations with a high incidence of VTE. Further studies to identify medical patients who are at high risk and would benefit from prophylaxis are warranted. (Less)
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author
; ; ; and
organization
alternative title
Evidence for thrombosis prophylaxis to high-risk patients
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Fibrinolytika, Ventrombos, Blodförtunningsmedel, Blodproppssjukdomar
in
Läkartidningen
volume
104
issue
20-21
pages
1585 - 1587
publisher
Swedish Medical Association
external identifiers
  • pmid:17564265
  • scopus:34249008480
ISSN
0023-7205
language
Swedish
LU publication?
yes
id
b6c5e3fc-0155-438b-b4a2-480ec7062f78 (old id 1139956)
alternative location
http://ltarkiv.lakartidningen.se/artNo33449
date added to LUP
2016-04-01 16:49:06
date last changed
2022-01-28 22:23:09
@article{b6c5e3fc-0155-438b-b4a2-480ec7062f78,
  abstract     = {{Venous thromboembolism (VTE) is a common complication of hospitalization, and can result in substantial morbidity and treatment cost. In orthopedic and general surgery, it is common practice to use low-molecular-weight heparin as a thromboprophylaxis. For medical patients, however, the issue of prophylaxis remains under debate. Data from three recent large randomized studies of medical patients at risk for VTE: PREVENT, MEDENOX and ARTEMIS, were combined. They showed an absolute risk reduction (ARR) for symptomatic VTE of 0,48 percent, asymptomatic VTE of 2,5 percent with a subsequent increase in major bleedings of 0,38 percent. In most studies, low-molecular-weight heparin reduces the risk of VTE by approximately 45 percent. Thus, the prophylaxis may be efficient, but its clinical use is limited to patient populations with a high incidence of VTE. Further studies to identify medical patients who are at high risk and would benefit from prophylaxis are warranted.}},
  author       = {{Själander, Anders and Jansson, Jan-Åke and Bergqvist, David and Eriksson, Henry and Svensson, Peter}},
  issn         = {{0023-7205}},
  keywords     = {{Fibrinolytika; Ventrombos; Blodförtunningsmedel; Blodproppssjukdomar}},
  language     = {{swe}},
  number       = {{20-21}},
  pages        = {{1585--1587}},
  publisher    = {{Swedish Medical Association}},
  series       = {{Läkartidningen}},
  title        = {{Evidens för trombosprofylax till medicinpatienter med hög risk}},
  url          = {{http://ltarkiv.lakartidningen.se/artNo33449}},
  volume       = {{104}},
  year         = {{2007}},
}