Expression of Ndufb11 encoding the neuronal protein 15.6 during neurite outgrowth and development
(2007) In Gene Expression Patterns 7(3). p.370-374- Abstract
- Neurite outgrowth (e.g. axonal or dendrite outgrowth) of neurons is necessary for the development and functioning of the central nervous system. It is well accepted that the differentiation of neurons and neurite outgrowth involve alterations in gene expression. Furthermore, mitochondria play a role in different aspects of neurite outgrowth. Here we show that the expression of Ndufb11, a gene encoding the mitochondrial protein NP15.6 is decreased in the course of neuronal differentiation. NP15.6 is homologous to the bovine protein ESSS, a component of the mitochondrial complex 1. The homologous human NDUFB11 gene is localized to Xp11.3-Xp11.23, a region associated with neurogenetic disorders. The down-regulation of NP15.6 correlates with... (More)
- Neurite outgrowth (e.g. axonal or dendrite outgrowth) of neurons is necessary for the development and functioning of the central nervous system. It is well accepted that the differentiation of neurons and neurite outgrowth involve alterations in gene expression. Furthermore, mitochondria play a role in different aspects of neurite outgrowth. Here we show that the expression of Ndufb11, a gene encoding the mitochondrial protein NP15.6 is decreased in the course of neuronal differentiation. NP15.6 is homologous to the bovine protein ESSS, a component of the mitochondrial complex 1. The homologous human NDUFB11 gene is localized to Xp11.3-Xp11.23, a region associated with neurogenetic disorders. The down-regulation of NP15.6 correlates with neurite outgrowth of PC12 cells induced by nerve growth factor. Furthermore, we analyzed the expression of Ndufb11 in the embryonic and adult mouse. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1143557
- author
- Gurok, Ulf ; Bork, Kaya ; Nuber, Ulrike LU ; Sporle, Ralf ; Nohring, Sabine and Horstkorte, Rudiger
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Gene Expression Patterns
- volume
- 7
- issue
- 3
- pages
- 370 - 374
- publisher
- Elsevier
- external identifiers
-
- pmid:16962385
- scopus:33751558450
- pmid:16962385
- ISSN
- 1567-133X
- DOI
- 10.1016/j.modgep.2006.07.004
- language
- English
- LU publication?
- no
- id
- 4aa0cd8e-5b98-481b-b86a-d91380d9c731 (old id 1143557)
- date added to LUP
- 2016-04-01 16:17:49
- date last changed
- 2022-01-28 18:44:48
@article{4aa0cd8e-5b98-481b-b86a-d91380d9c731,
abstract = {{Neurite outgrowth (e.g. axonal or dendrite outgrowth) of neurons is necessary for the development and functioning of the central nervous system. It is well accepted that the differentiation of neurons and neurite outgrowth involve alterations in gene expression. Furthermore, mitochondria play a role in different aspects of neurite outgrowth. Here we show that the expression of Ndufb11, a gene encoding the mitochondrial protein NP15.6 is decreased in the course of neuronal differentiation. NP15.6 is homologous to the bovine protein ESSS, a component of the mitochondrial complex 1. The homologous human NDUFB11 gene is localized to Xp11.3-Xp11.23, a region associated with neurogenetic disorders. The down-regulation of NP15.6 correlates with neurite outgrowth of PC12 cells induced by nerve growth factor. Furthermore, we analyzed the expression of Ndufb11 in the embryonic and adult mouse.}},
author = {{Gurok, Ulf and Bork, Kaya and Nuber, Ulrike and Sporle, Ralf and Nohring, Sabine and Horstkorte, Rudiger}},
issn = {{1567-133X}},
language = {{eng}},
number = {{3}},
pages = {{370--374}},
publisher = {{Elsevier}},
series = {{Gene Expression Patterns}},
title = {{Expression of Ndufb11 encoding the neuronal protein 15.6 during neurite outgrowth and development}},
url = {{http://dx.doi.org/10.1016/j.modgep.2006.07.004}},
doi = {{10.1016/j.modgep.2006.07.004}},
volume = {{7}},
year = {{2007}},
}