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An improved method for detecting and delineating genomic regions with altered gene expression in cancer

Nilsson, Björn LU ; Johansson, Mikael ; Heyden, Anders LU orcid ; Nelander, Sven and Fioretos, Thoas LU (2008) In Genome Biology 9(1).
Abstract
ABSTRACT: Genomic regions with altered gene expression are a characteristic feature of cancer cells. We present a novel method for identifying such regions in gene expression maps. This method is based on total variation (TV) minimization, a classical signal restoration technique. In systematic evaluations, we show that our method combines top-notch detection performance with an ability to delineate relevant regions without excessive over-segmentation, making it a significant advance over existing methods. Software (Rendersome) is provided.
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Genome Biology
volume
9
issue
1
article number
R13
publisher
BioMed Central (BMC)
external identifiers
  • pmid:18208590
  • wos:000253779800021
  • scopus:46249086537
  • pmid:18208590
ISSN
1474-7596
DOI
10.1186/gb-2008-9-1-r13
language
English
LU publication?
yes
id
76b0d4ba-4057-424d-bcfb-8dae11c50cc0 (old id 1143863)
date added to LUP
2016-04-01 13:09:25
date last changed
2023-09-02 19:44:55
@article{76b0d4ba-4057-424d-bcfb-8dae11c50cc0,
  abstract     = {{ABSTRACT: Genomic regions with altered gene expression are a characteristic feature of cancer cells. We present a novel method for identifying such regions in gene expression maps. This method is based on total variation (TV) minimization, a classical signal restoration technique. In systematic evaluations, we show that our method combines top-notch detection performance with an ability to delineate relevant regions without excessive over-segmentation, making it a significant advance over existing methods. Software (Rendersome) is provided.}},
  author       = {{Nilsson, Björn and Johansson, Mikael and Heyden, Anders and Nelander, Sven and Fioretos, Thoas}},
  issn         = {{1474-7596}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Genome Biology}},
  title        = {{An improved method for detecting and delineating genomic regions with altered gene expression in cancer}},
  url          = {{http://dx.doi.org/10.1186/gb-2008-9-1-r13}},
  doi          = {{10.1186/gb-2008-9-1-r13}},
  volume       = {{9}},
  year         = {{2008}},
}