Cytogenetic and morphologic subgroups of myelodysplastic syndromes in relation to occupational and hobby exposures.

Albin, Maria; Björk, Jonas; Welinder, Hans; Tinnerberg, Håkan; Mauritzson, Nils; Billström, Rolf; Strömberg, Ulf; Mikoczy, Zoli; Johansson, Bertil; Ahlgren, Tomas; Nilsson, Per-Gunnar; Mitelman, Felix; Hagmar, Lars

Cytogenetic and morphologic subgroups of myelodysplastic syndromes in relation to occupational and hobby exposures.

Mark

Albin, Maria ^LU ; Björk, Jonas ^LU ; Welinder, Hans ^LU ; Tinnerberg, Håkan ^LU ; Mauritzson, Nils ; Billström, Rolf ; Strömberg, Ulf ^LU ; Mikoczy, Zoli ^LU ; Johansson, Bertil and Ahlgren, Tomas , et al. (2003) In Scandinavian Journal of Work, Environment and Health 29(5). p.378-387

Abstract: OBJECTIVES: This study investigated the association between occupational and hobby exposure and the risk of myelodysplastic syndromes (MDS) while focusing on differential patterns of clonal chromosome aberrations and morphologic subgroups. METHODS: A case-referent study was conducted with 330 MDS patients investigated cytogenetically in 1976-1993 (cases) and matched referents. Telephone interviews with either the person or a next-of-kin were used. The participation rate of the cases and referents was 85% and 60%, respectively. Information was obtained from the next-of-kin more often for the cases (88%) than for the referents (26%). Occupational hygienists assessed the exposure using interview data on worktasks and hobbies. Associations... (More); OBJECTIVES: This study investigated the association between occupational and hobby exposure and the risk of myelodysplastic syndromes (MDS) while focusing on differential patterns of clonal chromosome aberrations and morphologic subgroups. METHODS: A case-referent study was conducted with 330 MDS patients investigated cytogenetically in 1976-1993 (cases) and matched referents. Telephone interviews with either the person or a next-of-kin were used. The participation rate of the cases and referents was 85% and 60%, respectively. Information was obtained from the next-of-kin more often for the cases (88%) than for the referents (26%). Occupational hygienists assessed the exposure using interview data on worktasks and hobbies. Associations with disease risk were evaluated for 10 exposures with a logistic regression analysis. RESULTS: The investigated exposures were generally not associated with cytogenetically abnormal MDS. Effect estimates for specific cytogenetic or morphologic subgroups were generally imprecise. Occupational exposure to extremely low-frequency magnetic fields (EMF) was associated with MDS with a normal karyotype [odds ratio (OR) 2.0, 95% confidence interval (95% CI) 1.0-4.0]. The exposure-response association was consistent for intensity but inconclusive for duration. A decreased risk was observed for MDS, irrespective of karyotypic pattern, among farmers and farmhands (OR 0.53, 95% CI 0.35-0.81). CONCLUSIONS: Cytogenetically abnormal MDS was generally not associated with occupational or hobby exposure to known or suspected genotoxic agents. However, exposure prevalences and intensities were low for several agents. An association was suggested between occupational exposure to EMF and MDS with a normal karyotype. Biases due to differential information quality and selective participation cannot be ruled out. (Less)

Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/118166

author

Albin, Maria ^LU ; Björk, Jonas ^LU ; Welinder, Hans ^LU ; Tinnerberg, Håkan ^LU ; Mauritzson, Nils ; Billström, Rolf ; Strömberg, Ulf ^LU ; Mikoczy, Zoli ^LU ; Johansson, Bertil and Ahlgren, Tomas , et al. (More)

Albin, Maria ^LU ; Björk, Jonas ^LU ; Welinder, Hans ^LU ; Tinnerberg, Håkan ^LU ; Mauritzson, Nils ; Billström, Rolf ; Strömberg, Ulf ^LU ; Mikoczy, Zoli ^LU ; Johansson, Bertil ; Ahlgren, Tomas ; Nilsson, Per-Gunnar ; Mitelman, Felix ^LU

and Hagmar, Lars (Less)

organization

publishing date

2003

type

Contribution to journal

publication status

published

subject

Environmental Health and Occupational Health

in

Scandinavian Journal of Work, Environment and Health

volume

29

issue

5

pages

378 - 387

publisher

Finnish Institute of Occupational Health

external identifiers

wos:000186016900007
pmid:14584518
scopus:10744232773

ISSN

0355-3140

language

English

LU publication?

yes

id

8700cb40-c0e0-43ed-9fe2-f5278582f532 (old id 118166)

alternative location

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=14584518&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

http://www.sjweh.fi/sjweh_file/files/j_03_5/art_03_5_378.pdf

date added to LUP

2016-04-01 12:09:19

date last changed

2022-01-26 23:36:18

@article{8700cb40-c0e0-43ed-9fe2-f5278582f532,
  abstract     = {{OBJECTIVES: This study investigated the association between occupational and hobby exposure and the risk of myelodysplastic syndromes (MDS) while focusing on differential patterns of clonal chromosome aberrations and morphologic subgroups. METHODS: A case-referent study was conducted with 330 MDS patients investigated cytogenetically in 1976-1993 (cases) and matched referents. Telephone interviews with either the person or a next-of-kin were used. The participation rate of the cases and referents was 85% and 60%, respectively. Information was obtained from the next-of-kin more often for the cases (88%) than for the referents (26%). Occupational hygienists assessed the exposure using interview data on worktasks and hobbies. Associations with disease risk were evaluated for 10 exposures with a logistic regression analysis. RESULTS: The investigated exposures were generally not associated with cytogenetically abnormal MDS. Effect estimates for specific cytogenetic or morphologic subgroups were generally imprecise. Occupational exposure to extremely low-frequency magnetic fields (EMF) was associated with MDS with a normal karyotype [odds ratio (OR) 2.0, 95% confidence interval (95% CI) 1.0-4.0]. The exposure-response association was consistent for intensity but inconclusive for duration. A decreased risk was observed for MDS, irrespective of karyotypic pattern, among farmers and farmhands (OR 0.53, 95% CI 0.35-0.81). CONCLUSIONS: Cytogenetically abnormal MDS was generally not associated with occupational or hobby exposure to known or suspected genotoxic agents. However, exposure prevalences and intensities were low for several agents. An association was suggested between occupational exposure to EMF and MDS with a normal karyotype. Biases due to differential information quality and selective participation cannot be ruled out.}},
  author       = {{Albin, Maria and Björk, Jonas and Welinder, Hans and Tinnerberg, Håkan and Mauritzson, Nils and Billström, Rolf and Strömberg, Ulf and Mikoczy, Zoli and Johansson, Bertil and Ahlgren, Tomas and Nilsson, Per-Gunnar and Mitelman, Felix and Hagmar, Lars}},
  issn         = {{0355-3140}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{378--387}},
  publisher    = {{Finnish Institute of Occupational Health}},
  series       = {{Scandinavian Journal of Work, Environment and Health}},
  title        = {{Cytogenetic and morphologic subgroups of myelodysplastic syndromes in relation to occupational and hobby exposures.}},
  url          = {{http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=14584518&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum}},
  volume       = {{29}},
  year         = {{2003}},
}

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Cytogenetic and morphologic subgroups of myelodysplastic syndromes in relation to occupational and hobby exposures.