Complex formed in the system hydrophobically modified polyethylene glycol/methylated alpha-cyclodextrin/water. An NMR diffusometry study
(2003) In Colloids and Surfaces A: Physicochemical and Engineering Aspects 228(1-3). p.171-179- Abstract
- In aqueous solutions hydrophobically modified polyethylene glycol (HM-PEG) forms a transient polymer network held together by intermolecular hydrophobic associations. In the present investigation we have used NMR-diffusometry to study how the addition of methylated alpha-cyclodextrin (M-alpha-CD) influences the polymer network. The addit
on of M-alpha-CD resulted in an increased mean self-diffusion of HM-PEG,
DHM-PEG, which is referred to a degradation of the polymer network when
hydrophobic associations are disrupted due to complex formation between
the hydrophobic groups of HM-PEG and M-alpha-CD. Addition of small
amounts of M-alpha-CD results in a dramatic increase in DHM-PEG.... (More) - In aqueous solutions hydrophobically modified polyethylene glycol (HM-PEG) forms a transient polymer network held together by intermolecular hydrophobic associations. In the present investigation we have used NMR-diffusometry to study how the addition of methylated alpha-cyclodextrin (M-alpha-CD) influences the polymer network. The addit
on of M-alpha-CD resulted in an increased mean self-diffusion of HM-PEG,
DHM-PEG, which is referred to a degradation of the polymer network when
hydrophobic associations are disrupted due to complex formation between
the hydrophobic groups of HM-PEG and M-alpha-CD. Addition of small
amounts of M-alpha-CD results in a dramatic increase in DHM-PEG. Upon
further addition of M-a-CD the increase in DHM-PEG is less dramatic and
at excess M-alpha-CD, DHM-PEG levels off and equals the mean
self-diffusion coefficient for unmodified PEG with the same molecular
weight. The suggested interpretation is that the addition of the first
molecules of M-alpha-CD mainly reduces the probability for hydrophobic
associations inter-connecting different clusters of polymer micelles
whereas at higher M-alpha-CD concentrations a disengagement of the
individual clusters into separate HM-PEG molecules becomes
important. (C) 2003 Elsevier B.V. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/122039
- author
- Karlson, L ; Malmborg, Carin LU ; Thuresson, Krister LU and Söderman, Olle LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Hydrophobically modified polyethylene glycol, Methylated α-cyclodextrin, NMR diffusometry
- in
- Colloids and Surfaces A: Physicochemical and Engineering Aspects
- volume
- 228
- issue
- 1-3
- pages
- 171 - 179
- publisher
- Elsevier
- external identifiers
-
- wos:000187181300017
- scopus:0242593964
- ISSN
- 0927-7757
- DOI
- 10.1016/S0927-7757(03)00333-9
- language
- English
- LU publication?
- yes
- id
- 26581057-243f-415b-8e79-3eca701348ab (old id 122039)
- date added to LUP
- 2016-04-01 15:48:04
- date last changed
- 2022-04-07 00:56:06
@article{26581057-243f-415b-8e79-3eca701348ab,
abstract = {{In aqueous solutions hydrophobically modified polyethylene glycol (HM-PEG) forms a transient polymer network held together by intermolecular hydrophobic associations. In the present investigation we have used NMR-diffusometry to study how the addition of methylated alpha-cyclodextrin (M-alpha-CD) influences the polymer network. The addit<br/><br>
on of M-alpha-CD resulted in an increased mean self-diffusion of HM-PEG,<br/><br>
DHM-PEG, which is referred to a degradation of the polymer network when<br/><br>
hydrophobic associations are disrupted due to complex formation between<br/><br>
the hydrophobic groups of HM-PEG and M-alpha-CD. Addition of small<br/><br>
amounts of M-alpha-CD results in a dramatic increase in DHM-PEG. Upon<br/><br>
further addition of M-a-CD the increase in DHM-PEG is less dramatic and<br/><br>
at excess M-alpha-CD, DHM-PEG levels off and equals the mean<br/><br>
self-diffusion coefficient for unmodified PEG with the same molecular<br/><br>
weight. The suggested interpretation is that the addition of the first<br/><br>
molecules of M-alpha-CD mainly reduces the probability for hydrophobic<br/><br>
associations inter-connecting different clusters of polymer micelles<br/><br>
whereas at higher M-alpha-CD concentrations a disengagement of the<br/><br>
individual clusters into separate HM-PEG molecules becomes<br/><br>
important. (C) 2003 Elsevier B.V. All rights reserved.}},
author = {{Karlson, L and Malmborg, Carin and Thuresson, Krister and Söderman, Olle}},
issn = {{0927-7757}},
keywords = {{Hydrophobically modified polyethylene glycol; Methylated α-cyclodextrin; NMR diffusometry}},
language = {{eng}},
number = {{1-3}},
pages = {{171--179}},
publisher = {{Elsevier}},
series = {{Colloids and Surfaces A: Physicochemical and Engineering Aspects}},
title = {{Complex formed in the system hydrophobically modified polyethylene glycol/methylated alpha-cyclodextrin/water. An NMR diffusometry study}},
url = {{http://dx.doi.org/10.1016/S0927-7757(03)00333-9}},
doi = {{10.1016/S0927-7757(03)00333-9}},
volume = {{228}},
year = {{2003}},
}