Development of Humanized Ossicles : Bridging the Hematopoietic Gap
Dupard, Steven J. LU ; Grigoryan, Ani LU ; Farhat, Stephanie ; Coutu, Daniel L. and Bourgine, Paul E. LU
(2020)
In Trends in Molecular Medicine
26(6).
p.552-569
- Abstract
Ectopic 'humanized ossicles' (hOss) are miniaturized, engineered human bone organs in mice displaying a similar structure and function to native mouse bones. However, they are composed of human mesenchymal derived cells forming a humanized bone marrow niche. This in vivo reconstitution of human skeletal and hematopoietic compartments provides an opportunity to investigate the cellular and molecular processes involved in their establishment and functions in a human setting. However, current hOs strategies vary in their engineering methods and their downstream applications, undermining comprehensive exploitation of their potential. This review describes the specificities of the hOs models and highlights their potential and limits.... (More)
Ectopic 'humanized ossicles' (hOss) are miniaturized, engineered human bone organs in mice displaying a similar structure and function to native mouse bones. However, they are composed of human mesenchymal derived cells forming a humanized bone marrow niche. This in vivo reconstitution of human skeletal and hematopoietic compartments provides an opportunity to investigate the cellular and molecular processes involved in their establishment and functions in a human setting. However, current hOs strategies vary in their engineering methods and their downstream applications, undermining comprehensive exploitation of their potential. This review describes the specificities of the hOs models and highlights their potential and limits. Ultimately, we propose directions for the development of hOss as a technological platform for human hematopoietic studies.
(Less)
- author
- Dupard, Steven J.
LU
; Grigoryan, Ani
LU
; Farhat, Stephanie
; Coutu, Daniel L.
and Bourgine, Paul E.
LU
- organization
- publishing date
- 2020-06-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- bone marrow niche, bone tissue engineering, hematopoiesis, hematopoietic stem cells, humanized ossicle, mesenchymal stromal cells
- in
- Trends in Molecular Medicine
- volume
- 26
- issue
- 6
- pages
- 18 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85080905352
- pmid:32470383
- ISSN
- 1471-4914
- DOI
- 10.1016/j.molmed.2020.01.016
- language
- English
- LU publication?
- yes
- id
- 132dbd87-58fa-4acf-a207-a4c1bf99b0cb
- date added to LUP
- 2020-03-20 16:45:05
- date last changed
- 2024-03-20 06:48:34
@article{132dbd87-58fa-4acf-a207-a4c1bf99b0cb,
abstract = {{<p>Ectopic 'humanized ossicles' (hOss) are miniaturized, engineered human bone organs in mice displaying a similar structure and function to native mouse bones. However, they are composed of human mesenchymal derived cells forming a humanized bone marrow niche. This in vivo reconstitution of human skeletal and hematopoietic compartments provides an opportunity to investigate the cellular and molecular processes involved in their establishment and functions in a human setting. However, current hOs strategies vary in their engineering methods and their downstream applications, undermining comprehensive exploitation of their potential. This review describes the specificities of the hOs models and highlights their potential and limits. Ultimately, we propose directions for the development of hOss as a technological platform for human hematopoietic studies.</p>}},
author = {{Dupard, Steven J. and Grigoryan, Ani and Farhat, Stephanie and Coutu, Daniel L. and Bourgine, Paul E.}},
issn = {{1471-4914}},
keywords = {{bone marrow niche; bone tissue engineering; hematopoiesis; hematopoietic stem cells; humanized ossicle; mesenchymal stromal cells}},
language = {{eng}},
month = {{06}},
number = {{6}},
pages = {{552--569}},
publisher = {{Elsevier}},
series = {{Trends in Molecular Medicine}},
title = {{Development of Humanized Ossicles : Bridging the Hematopoietic Gap}},
url = {{http://dx.doi.org/10.1016/j.molmed.2020.01.016}},
doi = {{10.1016/j.molmed.2020.01.016}},
volume = {{26}},
year = {{2020}},
}