Enriched environment enhances recovery of motor function after focal ischemia in mice, and downregulates the transcription factor NGFI-A.
(2005) In Journal of Cerebral Blood Flow and Metabolism 25(12). p.1625-1633- Abstract
- The purpose of this study was to investigate the effect of enriched environment on motor function after experimental stroke in mice, and to determine whether time in enriched environment affects functional recovery. Earlier investigations have shown that rats placed in an enriched environment after focal ischemia, remarkably improve motor function, but similar observations in mice have not been reported. In this study, we show that placing mice in an enriched environment for 3 h daily for 2 weeks, after transient (50 mins) occlusion of the middle cerebral artery, enhanced neurologic outcome. Continuous postischemic housing in the enriched environment likewise improved motor function, but mortality increased. Two weeks exposure to enriched... (More)
- The purpose of this study was to investigate the effect of enriched environment on motor function after experimental stroke in mice, and to determine whether time in enriched environment affects functional recovery. Earlier investigations have shown that rats placed in an enriched environment after focal ischemia, remarkably improve motor function, but similar observations in mice have not been reported. In this study, we show that placing mice in an enriched environment for 3 h daily for 2 weeks, after transient (50 mins) occlusion of the middle cerebral artery, enhanced neurologic outcome. Continuous postischemic housing in the enriched environment likewise improved motor function, but mortality increased. Two weeks exposure to enriched environment followed by housing the mice in standard cages for 2 weeks, resulted in a loss of the improved motor function. In contrast, 4 weeks exposure to enriched environment led to an improved motor function and to a better maintenance of neurologic recovery. The expression levels of the immediate-early gene nerve growth factor-induced gene A at 2 to 3 weeks of recovery decreased in animals housed in enriched environment, implying this transcription factor in the recovery process. We conclude that housing mice in an enriched environment after experimental stroke improves functional outcome. Also, the presented experimental procedure is useful for further studies of the genomics of functional recovery after experimental stroke. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/137808
- author
- Nygren, Josefine LU and Wieloch, Tadeusz LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- enriched environment, stroke, NGFI-A, mice, brain plasticity
- in
- Journal of Cerebral Blood Flow and Metabolism
- volume
- 25
- issue
- 12
- pages
- 1625 - 1633
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000235939600006
- pmid:15917744
- scopus:28044468869
- ISSN
- 1559-7016
- DOI
- 10.1038/sj.jcbfm.9600157
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Experimental Brain Research (0131000120), Laboratory for Experimental Brain Research (013041000)
- id
- ab5f8138-7e7c-48a9-81df-0895fd994240 (old id 137808)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15917744&dopt=Abstract
- date added to LUP
- 2016-04-01 17:04:32
- date last changed
- 2022-01-29 00:11:56
@article{ab5f8138-7e7c-48a9-81df-0895fd994240,
abstract = {{The purpose of this study was to investigate the effect of enriched environment on motor function after experimental stroke in mice, and to determine whether time in enriched environment affects functional recovery. Earlier investigations have shown that rats placed in an enriched environment after focal ischemia, remarkably improve motor function, but similar observations in mice have not been reported. In this study, we show that placing mice in an enriched environment for 3 h daily for 2 weeks, after transient (50 mins) occlusion of the middle cerebral artery, enhanced neurologic outcome. Continuous postischemic housing in the enriched environment likewise improved motor function, but mortality increased. Two weeks exposure to enriched environment followed by housing the mice in standard cages for 2 weeks, resulted in a loss of the improved motor function. In contrast, 4 weeks exposure to enriched environment led to an improved motor function and to a better maintenance of neurologic recovery. The expression levels of the immediate-early gene nerve growth factor-induced gene A at 2 to 3 weeks of recovery decreased in animals housed in enriched environment, implying this transcription factor in the recovery process. We conclude that housing mice in an enriched environment after experimental stroke improves functional outcome. Also, the presented experimental procedure is useful for further studies of the genomics of functional recovery after experimental stroke.}},
author = {{Nygren, Josefine and Wieloch, Tadeusz}},
issn = {{1559-7016}},
keywords = {{enriched environment; stroke; NGFI-A; mice; brain plasticity}},
language = {{eng}},
number = {{12}},
pages = {{1625--1633}},
publisher = {{Nature Publishing Group}},
series = {{Journal of Cerebral Blood Flow and Metabolism}},
title = {{Enriched environment enhances recovery of motor function after focal ischemia in mice, and downregulates the transcription factor NGFI-A.}},
url = {{http://dx.doi.org/10.1038/sj.jcbfm.9600157}},
doi = {{10.1038/sj.jcbfm.9600157}},
volume = {{25}},
year = {{2005}},
}