beta(1) integrins are not required for the maintenance of lymphocytes within intestinal epithelia.
(2005) In European Journal of Immunology 35(6). p.1805-1811- Abstract
- b1 integrins are thought to play a central role in maintaining lymphocytes within
mucosal epithelia via their interactions with extracellular matrix proteins and
subepithelial cellular components within and underlying the basement membrane.
In the current study type a (CD8abTCRab) and type b (CD8aaTCRcd and
CD8aaTCRab) intraepithelial lymphocyte (IEL) subsets within the mouse small
intestine were found to express functional b1 integrin and the b1 integrin a chain
partners a1, a2, and a4. Using inducible b1 integrin-knockout bone marrow-chimeric
mice we demonstrate that IEL expression of a1 and a2 but not a4 is dependent on
expression of the b1 chain. Importantly,... (More) - b1 integrins are thought to play a central role in maintaining lymphocytes within
mucosal epithelia via their interactions with extracellular matrix proteins and
subepithelial cellular components within and underlying the basement membrane.
In the current study type a (CD8abTCRab) and type b (CD8aaTCRcd and
CD8aaTCRab) intraepithelial lymphocyte (IEL) subsets within the mouse small
intestine were found to express functional b1 integrin and the b1 integrin a chain
partners a1, a2, and a4. Using inducible b1 integrin-knockout bone marrow-chimeric
mice we demonstrate that IEL expression of a1 and a2 but not a4 is dependent on
expression of the b1 chain. Importantly, deletion of the b1 chain in IEL did not alter the
number or composition of lymphocytes within the intestinal epithelium. Thus, while IEL
express functional b1 integrins, these are not required to maintain lymphocytes within
intestinal epithelia. This result is discussed in the light of conventional views of
intestinal lymphocyte homing and localization. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/138067
- author
- Marsal, Jan LU ; Brakebusch, Cord ; Bungartz, Gerd ; Fässler, Reinhard and Agace, William LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- T lymphocytes, Adhesion molecules, Mucosa
- in
- European Journal of Immunology
- volume
- 35
- issue
- 6
- pages
- 1805 - 1811
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:15884052
- wos:000229947300015
- scopus:20844462939
- ISSN
- 1521-4141
- DOI
- 10.1002/eji.200425941
- language
- English
- LU publication?
- yes
- id
- 422dc890-8af2-4c9c-a800-70c540a84a06 (old id 138067)
- date added to LUP
- 2016-04-01 12:21:50
- date last changed
- 2022-01-27 02:43:08
@article{422dc890-8af2-4c9c-a800-70c540a84a06,
abstract = {{b1 integrins are thought to play a central role in maintaining lymphocytes within<br/><br>
mucosal epithelia via their interactions with extracellular matrix proteins and<br/><br>
subepithelial cellular components within and underlying the basement membrane.<br/><br>
In the current study type a (CD8abTCRab) and type b (CD8aaTCRcd and<br/><br>
CD8aaTCRab) intraepithelial lymphocyte (IEL) subsets within the mouse small<br/><br>
intestine were found to express functional b1 integrin and the b1 integrin a chain<br/><br>
partners a1, a2, and a4. Using inducible b1 integrin-knockout bone marrow-chimeric<br/><br>
mice we demonstrate that IEL expression of a1 and a2 but not a4 is dependent on<br/><br>
expression of the b1 chain. Importantly, deletion of the b1 chain in IEL did not alter the<br/><br>
number or composition of lymphocytes within the intestinal epithelium. Thus, while IEL<br/><br>
express functional b1 integrins, these are not required to maintain lymphocytes within<br/><br>
intestinal epithelia. This result is discussed in the light of conventional views of<br/><br>
intestinal lymphocyte homing and localization.}},
author = {{Marsal, Jan and Brakebusch, Cord and Bungartz, Gerd and Fässler, Reinhard and Agace, William}},
issn = {{1521-4141}},
keywords = {{T lymphocytes; Adhesion molecules; Mucosa}},
language = {{eng}},
number = {{6}},
pages = {{1805--1811}},
publisher = {{John Wiley & Sons Inc.}},
series = {{European Journal of Immunology}},
title = {{beta(1) integrins are not required for the maintenance of lymphocytes within intestinal epithelia.}},
url = {{http://dx.doi.org/10.1002/eji.200425941}},
doi = {{10.1002/eji.200425941}},
volume = {{35}},
year = {{2005}},
}