Practical suggestions on how to differentiate dementia with Lewy bodies from Alzheimer's disease with common cognitive tests.
Palmqvist, Sebastian LU
; Hansson, Oskar
LU
; Minthon, Lennart
LU
and Londos, Elisabet
LU
(2009)
In International Journal of Geriatric Psychiatry
24.
p.1405-1412
- Abstract
- OBJECTIVE: Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia, but it is often underdiagnosed and mistaken for Alzheimer's disease (AD) with sometimes lethal consequences. Over 35 studies have established the differences between DLB and AD in neuropsychological tests, but none have provided easy interpretations of common tests suitable for the clinician. The aim of this study was to suggest practical interpretations of the Mini-Mental State Examination (MMSE), clock drawing, and cube-copying to identify DLB and differentiate it from AD. METHODS: Thirty-three DLB patients were matched according to gender, MMSE, and age with 66 AD patients. The median MMSE score was 24. Easy interpretations of the tests,... (More)
- OBJECTIVE: Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia, but it is often underdiagnosed and mistaken for Alzheimer's disease (AD) with sometimes lethal consequences. Over 35 studies have established the differences between DLB and AD in neuropsychological tests, but none have provided easy interpretations of common tests suitable for the clinician. The aim of this study was to suggest practical interpretations of the Mini-Mental State Examination (MMSE), clock drawing, and cube-copying to identify DLB and differentiate it from AD. METHODS: Thirty-three DLB patients were matched according to gender, MMSE, and age with 66 AD patients. The median MMSE score was 24. Easy interpretations of the tests, including the MMSE orientation subscore, were sought for. RESULTS: The identified criteria to separate DLB from AD were (1) the MMSE orientation score x 3 >/= the total MMSE score, (2) an impaired clock drawing, and (3) a non-3D cube-copying. If (1) was fulfilled, the sensitivity and specificity were 100 and 57% in patients with MMSE 21-27. If (1) and (2) were fulfilled in patients with MMSE 21-27, the sensitivity and specificity were 93 and 70%. If at least two of the three criteria were fulfilled, the sensitivity was 85%, and the specificity 75% regardless of MMSE score. CONCLUSION: If the orientation score x 3 >/= the total MMSE score together with an impaired clock drawing and possibly a non-3D cube-copying, the patient should be thoroughly investigated according to the DLB consensus criteria. Copyright (c) 2009 John Wiley & Sons, Ltd. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1392403
- author
- Palmqvist, Sebastian
LU
; Hansson, Oskar
LU
; Minthon, Lennart
LU
and Londos, Elisabet
LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Geriatric Psychiatry
- volume
- 24
- pages
- 1405 - 1412
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000272636000011
- pmid:19347836
- scopus:73249145387
- pmid:19347836
- ISSN
- 1099-1166
- DOI
- 10.1002/gps.2277
- language
- English
- LU publication?
- yes
- id
- aadaf461-cc94-4a6b-ac62-74e46e158529 (old id 1392403)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19347836?dopt=Abstract
- date added to LUP
- 2016-04-04 07:40:40
- date last changed
- 2022-03-30 22:34:34
@article{aadaf461-cc94-4a6b-ac62-74e46e158529,
abstract = {{OBJECTIVE: Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia, but it is often underdiagnosed and mistaken for Alzheimer's disease (AD) with sometimes lethal consequences. Over 35 studies have established the differences between DLB and AD in neuropsychological tests, but none have provided easy interpretations of common tests suitable for the clinician. The aim of this study was to suggest practical interpretations of the Mini-Mental State Examination (MMSE), clock drawing, and cube-copying to identify DLB and differentiate it from AD. METHODS: Thirty-three DLB patients were matched according to gender, MMSE, and age with 66 AD patients. The median MMSE score was 24. Easy interpretations of the tests, including the MMSE orientation subscore, were sought for. RESULTS: The identified criteria to separate DLB from AD were (1) the MMSE orientation score x 3 >/= the total MMSE score, (2) an impaired clock drawing, and (3) a non-3D cube-copying. If (1) was fulfilled, the sensitivity and specificity were 100 and 57% in patients with MMSE 21-27. If (1) and (2) were fulfilled in patients with MMSE 21-27, the sensitivity and specificity were 93 and 70%. If at least two of the three criteria were fulfilled, the sensitivity was 85%, and the specificity 75% regardless of MMSE score. CONCLUSION: If the orientation score x 3 >/= the total MMSE score together with an impaired clock drawing and possibly a non-3D cube-copying, the patient should be thoroughly investigated according to the DLB consensus criteria. Copyright (c) 2009 John Wiley & Sons, Ltd.}},
author = {{Palmqvist, Sebastian and Hansson, Oskar and Minthon, Lennart and Londos, Elisabet}},
issn = {{1099-1166}},
language = {{eng}},
pages = {{1405--1412}},
publisher = {{John Wiley & Sons Inc.}},
series = {{International Journal of Geriatric Psychiatry}},
title = {{Practical suggestions on how to differentiate dementia with Lewy bodies from Alzheimer's disease with common cognitive tests.}},
url = {{http://dx.doi.org/10.1002/gps.2277}},
doi = {{10.1002/gps.2277}},
volume = {{24}},
year = {{2009}},
}