Ncf1 (p47phox) polymorphism determines oxidative burst and the severity of arthritis in rats and mice.
(2005) In Cellular Immunology 233(2). p.97-101- Abstract
- Identifying genes that regulate polygenic diseases influenced by the environment such as rheumatoid arthritis (RA), has so far proven to be difficult. By using an alternative approach, i.e., linkage analysis using relevant animal models we succeeded in finding the Ncf1 gene residing in the Pia4 quantitative trait locus to be responsible for the severity of pristane induced arthritis in rats. The influence of another mutation in the mouse Ncf1 gene showed the same association between decreased oxidative burst and enhanced arthritis. In this case the mutation affected a splice site giving a non-detectable oxidative burst response and enhanced collagen induced arthritis as well as myelin oligodendrocyte protein induced experimental autoimmune... (More)
- Identifying genes that regulate polygenic diseases influenced by the environment such as rheumatoid arthritis (RA), has so far proven to be difficult. By using an alternative approach, i.e., linkage analysis using relevant animal models we succeeded in finding the Ncf1 gene residing in the Pia4 quantitative trait locus to be responsible for the severity of pristane induced arthritis in rats. The influence of another mutation in the mouse Ncf1 gene showed the same association between decreased oxidative burst and enhanced arthritis. In this case the mutation affected a splice site giving a non-detectable oxidative burst response and enhanced collagen induced arthritis as well as myelin oligodendrocyte protein induced experimental autoimmune encephalomyelitis. These findings open up new possibilities for new treatments for autoimmune diseases, i.e., RA, targeting the NADPH oxidase pathway. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/140235
- author
- Hultqvist, Malin LU and Holmdahl, Rikard LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- mice, Ncf1, arthritis, rat, NADPH
- in
- Cellular Immunology
- volume
- 233
- issue
- 2
- pages
- 97 - 101
- publisher
- Elsevier
- external identifiers
-
- wos:000231191100005
- pmid:15936744
- scopus:23044447997
- pmid:15936744
- ISSN
- 0008-8749
- DOI
- 10.1016/j.cellimm.2005.04.008
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019)
- id
- aca8bd92-1ae0-462b-8afc-6536f89dbf62 (old id 140235)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15936744&query_hl=6
- date added to LUP
- 2016-04-01 15:55:38
- date last changed
- 2022-01-28 08:06:01
@article{aca8bd92-1ae0-462b-8afc-6536f89dbf62,
abstract = {{Identifying genes that regulate polygenic diseases influenced by the environment such as rheumatoid arthritis (RA), has so far proven to be difficult. By using an alternative approach, i.e., linkage analysis using relevant animal models we succeeded in finding the Ncf1 gene residing in the Pia4 quantitative trait locus to be responsible for the severity of pristane induced arthritis in rats. The influence of another mutation in the mouse Ncf1 gene showed the same association between decreased oxidative burst and enhanced arthritis. In this case the mutation affected a splice site giving a non-detectable oxidative burst response and enhanced collagen induced arthritis as well as myelin oligodendrocyte protein induced experimental autoimmune encephalomyelitis. These findings open up new possibilities for new treatments for autoimmune diseases, i.e., RA, targeting the NADPH oxidase pathway.}},
author = {{Hultqvist, Malin and Holmdahl, Rikard}},
issn = {{0008-8749}},
keywords = {{mice; Ncf1; arthritis; rat; NADPH}},
language = {{eng}},
number = {{2}},
pages = {{97--101}},
publisher = {{Elsevier}},
series = {{Cellular Immunology}},
title = {{Ncf1 (p47phox) polymorphism determines oxidative burst and the severity of arthritis in rats and mice.}},
url = {{http://dx.doi.org/10.1016/j.cellimm.2005.04.008}},
doi = {{10.1016/j.cellimm.2005.04.008}},
volume = {{233}},
year = {{2005}},
}