Scaling up effects in the organic laboratory
(2004) In Journal of Chemical Education 81(9). p.1353-1354- Abstract
- A simple, yet safe and effective set of experiments to expose chemistry students to some of the effects that may be encountered when scaling up an organic reaction is described. The exothermic Diels–Alder reaction between maleic anhydride and cyclopentadiene was found to be ideal for our purposes and was performed in small, medium, and large scale for comparison. The observed differences of heat evolution between the three scales were significant. Also, to demonstrate how excess heat evolution can be controlled by simple means, two additional experiments in which the reaction was run either with small glass helices or water present were performed. The experiments were combined with some simple calculations that provided graphic... (More)
- A simple, yet safe and effective set of experiments to expose chemistry students to some of the effects that may be encountered when scaling up an organic reaction is described. The exothermic Diels–Alder reaction between maleic anhydride and cyclopentadiene was found to be ideal for our purposes and was performed in small, medium, and large scale for comparison. The observed differences of heat evolution between the three scales were significant. Also, to demonstrate how excess heat evolution can be controlled by simple means, two additional experiments in which the reaction was run either with small glass helices or water present were performed. The experiments were combined with some simple calculations that provided graphic illustrations of the observed differences, which aided the students in their understanding of the topic. This assignment can easily be adapted to work with both small and large groups of students. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/141209
- author
- Persson, Anna and Lindström, Ulf LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Chemical Education
- volume
- 81
- issue
- 9
- pages
- 1353 - 1354
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- wos:000223203100030
- scopus:4344632009
- ISSN
- 0021-9584
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
- id
- 0a17182e-987f-4d10-8504-8cfb8d7c28a7 (old id 141209)
- alternative location
- http://jchemed.chem.wisc.edu/Journal/Issues/2004/Sep/abs1353.html
- date added to LUP
- 2016-04-01 16:50:35
- date last changed
- 2022-01-28 22:33:59
@article{0a17182e-987f-4d10-8504-8cfb8d7c28a7,
abstract = {{A simple, yet safe and effective set of experiments to expose chemistry students to some of the effects that may be encountered when scaling up an organic reaction is described. The exothermic Diels–Alder reaction between maleic anhydride and cyclopentadiene was found to be ideal for our purposes and was performed in small, medium, and large scale for comparison. The observed differences of heat evolution between the three scales were significant. Also, to demonstrate how excess heat evolution can be controlled by simple means, two additional experiments in which the reaction was run either with small glass helices or water present were performed. The experiments were combined with some simple calculations that provided graphic illustrations of the observed differences, which aided the students in their understanding of the topic. This assignment can easily be adapted to work with both small and large groups of students.}},
author = {{Persson, Anna and Lindström, Ulf}},
issn = {{0021-9584}},
language = {{eng}},
number = {{9}},
pages = {{1353--1354}},
publisher = {{The American Chemical Society (ACS)}},
series = {{Journal of Chemical Education}},
title = {{Scaling up effects in the organic laboratory}},
url = {{http://jchemed.chem.wisc.edu/Journal/Issues/2004/Sep/abs1353.html}},
volume = {{81}},
year = {{2004}},
}