Airborne chemistry: acoustic levitation in chemical analysis
(2004) In Analytical and Bioanalytical Chemistry 378(7). p.1704-1709- Abstract
- This review with 60 references describes a unique path to miniaturisation, that is, the use of acoustic levitation in analytical and bioanalytical chemistry applications. Levitation of small volumes of sample by means of a levitation technique can be used as a way to avoid solid walls around the sample, thus circumventing the main problem of miniaturisation, the unfavourable surface-to-volume ratio. Different techniques for sample levitation have been developed and improved. Of the levitation techniques described, acoustic or ultrasonic levitation fulfils all requirements for analytical chemistry applications. This technique has previously been used to study properties of molten materials and the equilibrium shape and stability of liquid... (More)
- This review with 60 references describes a unique path to miniaturisation, that is, the use of acoustic levitation in analytical and bioanalytical chemistry applications. Levitation of small volumes of sample by means of a levitation technique can be used as a way to avoid solid walls around the sample, thus circumventing the main problem of miniaturisation, the unfavourable surface-to-volume ratio. Different techniques for sample levitation have been developed and improved. Of the levitation techniques described, acoustic or ultrasonic levitation fulfils all requirements for analytical chemistry applications. This technique has previously been used to study properties of molten materials and the equilibrium shape and stability of liquid drops. Temperature and mass transfer in levitated drops have also been described, as have crystallisation and microgravity applications.
The airborne analytical system described here is equipped with different and exchangeable remote detection systems. The levitated drops are normally in the 100 nL–2 mgrL volume range and additions to the levitated drop can be made in the pL-volume range.
The use of levitated drops in analytical and bioanalytical chemistry offers several benefits. Several remote detection systems are compatible with acoustic levitation, including fluorescence imaging detection, right angle light scattering, Raman spectroscopy, and X-ray diffraction. Applications include liquid/liquid extractions, solvent exchange, analyte enrichment, single-cell analysis, cell–cell communication studies, precipitation screening of proteins to establish nucleation conditions, and crystallisation of proteins and pharmaceuticals. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/141347
- author
- Santesson, Sabina LU and Nilsson, Staffan LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Analytical and Bioanalytical Chemistry
- volume
- 378
- issue
- 7
- pages
- 1704 - 1709
- publisher
- Springer
- external identifiers
-
- wos:000220458400007
- pmid:14762640
- scopus:17644390506
- ISSN
- 1618-2642
- DOI
- 10.1007/s00216-003-2403-2
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Analytical Chemistry (S/LTH) (011001004)
- id
- 519fd50f-0825-4cc4-8580-8cca352ce473 (old id 141347)
- date added to LUP
- 2016-04-01 11:39:03
- date last changed
- 2022-04-20 19:41:23
@article{519fd50f-0825-4cc4-8580-8cca352ce473,
abstract = {{This review with 60 references describes a unique path to miniaturisation, that is, the use of acoustic levitation in analytical and bioanalytical chemistry applications. Levitation of small volumes of sample by means of a levitation technique can be used as a way to avoid solid walls around the sample, thus circumventing the main problem of miniaturisation, the unfavourable surface-to-volume ratio. Different techniques for sample levitation have been developed and improved. Of the levitation techniques described, acoustic or ultrasonic levitation fulfils all requirements for analytical chemistry applications. This technique has previously been used to study properties of molten materials and the equilibrium shape and stability of liquid drops. Temperature and mass transfer in levitated drops have also been described, as have crystallisation and microgravity applications.<br/><br>
The airborne analytical system described here is equipped with different and exchangeable remote detection systems. The levitated drops are normally in the 100 nL–2 mgrL volume range and additions to the levitated drop can be made in the pL-volume range.<br/><br>
The use of levitated drops in analytical and bioanalytical chemistry offers several benefits. Several remote detection systems are compatible with acoustic levitation, including fluorescence imaging detection, right angle light scattering, Raman spectroscopy, and X-ray diffraction. Applications include liquid/liquid extractions, solvent exchange, analyte enrichment, single-cell analysis, cell–cell communication studies, precipitation screening of proteins to establish nucleation conditions, and crystallisation of proteins and pharmaceuticals.}},
author = {{Santesson, Sabina and Nilsson, Staffan}},
issn = {{1618-2642}},
language = {{eng}},
number = {{7}},
pages = {{1704--1709}},
publisher = {{Springer}},
series = {{Analytical and Bioanalytical Chemistry}},
title = {{Airborne chemistry: acoustic levitation in chemical analysis}},
url = {{http://dx.doi.org/10.1007/s00216-003-2403-2}},
doi = {{10.1007/s00216-003-2403-2}},
volume = {{378}},
year = {{2004}},
}