Hypotermi efter perinatal asfyxi minskar risken för hjärnskada. Men för tidigt att rekommendera rutinmässig behandling
(2005) In Läkartidningen 102(42). p.1-3030- Abstract
- Two randomised controlled trials evaluating intervention with moderate hypothermia after perinatal asphyxia will probably be published this year. The first study, evaluating head cooling with a "cool cap" is already published, and preliminary data from the other study evaluating body cooling earlier have been presented. Both studies indicate that moderate hypothermia, initiated within 6 h after birth, for 72 h reduces mortality and survival with severe brain injury. Several issues must, however, be solved before postasphyctic cooling can be recommended as clinical routine. There are no data on optimal duration, degree of cooling, best method, or if methods and degree of cooling should be adapted to type of brain injury. Continued research... (More)
- Two randomised controlled trials evaluating intervention with moderate hypothermia after perinatal asphyxia will probably be published this year. The first study, evaluating head cooling with a "cool cap" is already published, and preliminary data from the other study evaluating body cooling earlier have been presented. Both studies indicate that moderate hypothermia, initiated within 6 h after birth, for 72 h reduces mortality and survival with severe brain injury. Several issues must, however, be solved before postasphyctic cooling can be recommended as clinical routine. There are no data on optimal duration, degree of cooling, best method, or if methods and degree of cooling should be adapted to type of brain injury. Continued research with randomised controlled trials is recommended. (Less)
- Abstract (Swedish)
- Måttlig hypotermi efter perinatal asfyxi reducerar
mortaliteten och risken för överlevnad med svårt
handikapp, visar två randomiserade, kontrollerade
studier. Fler studier pågår och förväntas bli publicerade
inom de närmaste åren.
Den publicerade studien visar dock att det endast är
barn med måttlig hjärnskada som har effekt av hypotermi.
Hypotermi efter perinatal asfyxi kan ännu inte rekommenderas
som klinisk rutin. Det behövs mer kunskap
om dosering av hypotermin (duration, optimal temperatur)
i relation till den dominerande skadetypen
(kortikala eller basala ganglier).
Neonatalsektionen anordnade i september 2005 ett
... (More) - Måttlig hypotermi efter perinatal asfyxi reducerar
mortaliteten och risken för överlevnad med svårt
handikapp, visar två randomiserade, kontrollerade
studier. Fler studier pågår och förväntas bli publicerade
inom de närmaste åren.
Den publicerade studien visar dock att det endast är
barn med måttlig hjärnskada som har effekt av hypotermi.
Hypotermi efter perinatal asfyxi kan ännu inte rekommenderas
som klinisk rutin. Det behövs mer kunskap
om dosering av hypotermin (duration, optimal temperatur)
i relation till den dominerande skadetypen
(kortikala eller basala ganglier).
Neonatalsektionen anordnade i september 2005 ett
nationellt expertmöte om återupplivning och hypotermi.
Centra som vill starta hypotermibehandling rekommenderades
att ansluta sig till någon av de pågående
studierna. Möjligheterna att skapa en nordisk
multicenterstudie diskuterades också. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/147891
- author
- Hellström-Westas, Lena LU
- organization
- alternative title
- Hypothermia after perinatal asphyxia reduces the risk of brain damage. But it's too early to recommend the method for routine treatment
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Neonatal asfyxi, Kronisk hjärnskada, Framkallad hypotermi, Hypoxi-ischemi, hjärna
- in
- Läkartidningen
- volume
- 102
- issue
- 42
- pages
- 1 - 3030
- publisher
- Swedish Medical Association
- external identifiers
-
- pmid:16294526
- scopus:27644579561
- ISSN
- 0023-7205
- language
- Swedish
- LU publication?
- yes
- id
- e8c4084c-ddd9-45a9-b780-1a9598b18416 (old id 147891)
- alternative location
- http://ltarkiv.lakartidningen.se/artNo30832
- date added to LUP
- 2016-04-01 15:16:58
- date last changed
- 2022-01-28 04:37:36
@article{e8c4084c-ddd9-45a9-b780-1a9598b18416,
abstract = {{Two randomised controlled trials evaluating intervention with moderate hypothermia after perinatal asphyxia will probably be published this year. The first study, evaluating head cooling with a "cool cap" is already published, and preliminary data from the other study evaluating body cooling earlier have been presented. Both studies indicate that moderate hypothermia, initiated within 6 h after birth, for 72 h reduces mortality and survival with severe brain injury. Several issues must, however, be solved before postasphyctic cooling can be recommended as clinical routine. There are no data on optimal duration, degree of cooling, best method, or if methods and degree of cooling should be adapted to type of brain injury. Continued research with randomised controlled trials is recommended.}},
author = {{Hellström-Westas, Lena}},
issn = {{0023-7205}},
keywords = {{Neonatal asfyxi; Kronisk hjärnskada; Framkallad hypotermi; Hypoxi-ischemi; hjärna}},
language = {{swe}},
number = {{42}},
pages = {{1--3030}},
publisher = {{Swedish Medical Association}},
series = {{Läkartidningen}},
title = {{Hypotermi efter perinatal asfyxi minskar risken för hjärnskada. Men för tidigt att rekommendera rutinmässig behandling}},
url = {{http://ltarkiv.lakartidningen.se/artNo30832}},
volume = {{102}},
year = {{2005}},
}