The non-coding RNA of the multidrug resistance-linked vault particle encodes multiple regulatory small RNAs.
Persson, Helena LU
; Kvist, Anders
LU
; Vallon-Christersson, Johan
LU
; Medstrand, Patrik
LU
; Borg, Åke
LU
and Rovira, Carlos
LU
(2009)
In Nature Cell Biology
11(10).
p.1268-1271
- Abstract
- Vault particles are conserved organelles implicated in multidrug resistance and intracellular transport. They contain three different proteins and non-coding vault RNAs (vRNAs). Here we show that human vRNAs produce several small RNAs (svRNAs) by mechanisms different from those in the canonical microRNA (miRNA) pathway. At least one of these svRNAs, svRNAb, associates with Argonaute proteins to guide sequence-specific cleavage and regulate gene expression similarly to miRNAs. We demonstrate that svRNAb downregulates CYP3A4, a key enzyme in drug metabolism. Our findings expand the repertoire of small regulatory RNAs and assign, for the first time, a function to vRNAs that may help explain the association between vault particles and drug... (More)
- Vault particles are conserved organelles implicated in multidrug resistance and intracellular transport. They contain three different proteins and non-coding vault RNAs (vRNAs). Here we show that human vRNAs produce several small RNAs (svRNAs) by mechanisms different from those in the canonical microRNA (miRNA) pathway. At least one of these svRNAs, svRNAb, associates with Argonaute proteins to guide sequence-specific cleavage and regulate gene expression similarly to miRNAs. We demonstrate that svRNAb downregulates CYP3A4, a key enzyme in drug metabolism. Our findings expand the repertoire of small regulatory RNAs and assign, for the first time, a function to vRNAs that may help explain the association between vault particles and drug resistance. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1483540
- author
- Persson, Helena
LU
; Kvist, Anders
LU
; Vallon-Christersson, Johan
LU
; Medstrand, Patrik
LU
; Borg, Åke
LU
and Rovira, Carlos
LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Cell Biology
- volume
- 11
- issue
- 10
- pages
- 1268 - 1271
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000270382000018
- pmid:19749744
- scopus:70349652191
- ISSN
- 1465-7392
- DOI
- 10.1038/ncb1972
- language
- English
- LU publication?
- yes
- id
- 1a267a54-1563-4360-8753-0ea975cdc78f (old id 1483540)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19749744?dopt=Abstract
- date added to LUP
- 2016-04-04 09:20:36
- date last changed
- 2022-05-16 23:59:33
@article{1a267a54-1563-4360-8753-0ea975cdc78f,
abstract = {{Vault particles are conserved organelles implicated in multidrug resistance and intracellular transport. They contain three different proteins and non-coding vault RNAs (vRNAs). Here we show that human vRNAs produce several small RNAs (svRNAs) by mechanisms different from those in the canonical microRNA (miRNA) pathway. At least one of these svRNAs, svRNAb, associates with Argonaute proteins to guide sequence-specific cleavage and regulate gene expression similarly to miRNAs. We demonstrate that svRNAb downregulates CYP3A4, a key enzyme in drug metabolism. Our findings expand the repertoire of small regulatory RNAs and assign, for the first time, a function to vRNAs that may help explain the association between vault particles and drug resistance.}},
author = {{Persson, Helena and Kvist, Anders and Vallon-Christersson, Johan and Medstrand, Patrik and Borg, Åke and Rovira, Carlos}},
issn = {{1465-7392}},
language = {{eng}},
number = {{10}},
pages = {{1268--1271}},
publisher = {{Nature Publishing Group}},
series = {{Nature Cell Biology}},
title = {{The non-coding RNA of the multidrug resistance-linked vault particle encodes multiple regulatory small RNAs.}},
url = {{http://dx.doi.org/10.1038/ncb1972}},
doi = {{10.1038/ncb1972}},
volume = {{11}},
year = {{2009}},
}