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Glucose Detection With a Commercial MOSFET Using a ZnO Nanowires Extended Gate

Ali, Syed Muhammad Usman ; Nur, Omer ; Willander, Magnus and Danielsson, Bengt LU (2009) In IEEE Transactions on Nanotechnology 8(6). p.678-683
Abstract
ZnO nanowires were grown on Ag wire with a diameter of similar to 250 mu m and used in an electrochemical sensor. The enzyme glucose oxidase (GOD) was immobilized on the ZnO nanowires, and the Ag wire was connected directly to the gate of a MOSFET. Upon exposure to glucose (1-100 mu M), the electrochemical response from the GOD induced a stable measurable voltage change on the gate leading to a strong modulation of the current through the MOSFET. For a sensor with uniform ZnO nanowires functionalized with GOD, a fast response time of less than 100 ms was demonstrated. The effect of the uniformity of the ZnO nanowires on the sensing property was also investigated. The extended-gate arrangement facilitated glucose detection in small sample... (More)
ZnO nanowires were grown on Ag wire with a diameter of similar to 250 mu m and used in an electrochemical sensor. The enzyme glucose oxidase (GOD) was immobilized on the ZnO nanowires, and the Ag wire was connected directly to the gate of a MOSFET. Upon exposure to glucose (1-100 mu M), the electrochemical response from the GOD induced a stable measurable voltage change on the gate leading to a strong modulation of the current through the MOSFET. For a sensor with uniform ZnO nanowires functionalized with GOD, a fast response time of less than 100 ms was demonstrated. The effect of the uniformity of the ZnO nanowires on the sensing property was also investigated. The extended-gate arrangement facilitated glucose detection in small sample volumes, and made it possible to demonstrate the present sensor concept using a standard low-threshold MOSFET. The extended-gate MOSFET sensor approach demonstrates the possibility and potential of the use of nanostructures coupled to standard electronic components for biosensing applications. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
MOSFETs, electrochemical devices, Biomedical transducers, biosensor
in
IEEE Transactions on Nanotechnology
volume
8
issue
6
pages
678 - 683
publisher
IEEE - Institute of Electrical and Electronics Engineers Inc.
external identifiers
  • wos:000272047300003
  • scopus:70749117080
ISSN
1536-125X
DOI
10.1109/TNANO.2009.2019958
language
English
LU publication?
yes
id
3eceea8d-3d7f-4d57-819b-cc86a26bdec1 (old id 1518349)
date added to LUP
2016-04-01 14:09:43
date last changed
2022-03-21 22:33:29
@article{3eceea8d-3d7f-4d57-819b-cc86a26bdec1,
  abstract     = {{ZnO nanowires were grown on Ag wire with a diameter of similar to 250 mu m and used in an electrochemical sensor. The enzyme glucose oxidase (GOD) was immobilized on the ZnO nanowires, and the Ag wire was connected directly to the gate of a MOSFET. Upon exposure to glucose (1-100 mu M), the electrochemical response from the GOD induced a stable measurable voltage change on the gate leading to a strong modulation of the current through the MOSFET. For a sensor with uniform ZnO nanowires functionalized with GOD, a fast response time of less than 100 ms was demonstrated. The effect of the uniformity of the ZnO nanowires on the sensing property was also investigated. The extended-gate arrangement facilitated glucose detection in small sample volumes, and made it possible to demonstrate the present sensor concept using a standard low-threshold MOSFET. The extended-gate MOSFET sensor approach demonstrates the possibility and potential of the use of nanostructures coupled to standard electronic components for biosensing applications.}},
  author       = {{Ali, Syed Muhammad Usman and Nur, Omer and Willander, Magnus and Danielsson, Bengt}},
  issn         = {{1536-125X}},
  keywords     = {{MOSFETs; electrochemical devices; Biomedical transducers; biosensor}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{678--683}},
  publisher    = {{IEEE - Institute of Electrical and Electronics Engineers Inc.}},
  series       = {{IEEE Transactions on Nanotechnology}},
  title        = {{Glucose Detection With a Commercial MOSFET Using a ZnO Nanowires Extended Gate}},
  url          = {{http://dx.doi.org/10.1109/TNANO.2009.2019958}},
  doi          = {{10.1109/TNANO.2009.2019958}},
  volume       = {{8}},
  year         = {{2009}},
}