Absolute quantification of perfusion using dynamic susceptibility contrast MRI: pitfalls and possibilities.
Knutsson, Linda LU
; Ståhlberg, Freddy
LU
and Wirestam, Ronnie
LU
(2010)
In Magma
23.
p.1-21
- Abstract
- Absolute quantification of cerebral blood flow, cerebral blood volume and mean transit time is desirable in the determination of tissue viability thresholds and tissue at risk in acute ischaemic stroke, as well as in cases where a global reduction in cerebral blood flow is expected, for example, in patients with dementia or depressive disorders. Absolute values are also useful when comparing sequential examinations of tissue perfusion parameters, for example, in the monitoring and follow-up of various kinds of therapy. Regardless of the method employed, a number of assumptions and approximations must be made to obtain absolute measures of perfusion. Furthermore, the different stages of data acquisition and processing are associated with... (More)
- Absolute quantification of cerebral blood flow, cerebral blood volume and mean transit time is desirable in the determination of tissue viability thresholds and tissue at risk in acute ischaemic stroke, as well as in cases where a global reduction in cerebral blood flow is expected, for example, in patients with dementia or depressive disorders. Absolute values are also useful when comparing sequential examinations of tissue perfusion parameters, for example, in the monitoring and follow-up of various kinds of therapy. Regardless of the method employed, a number of assumptions and approximations must be made to obtain absolute measures of perfusion. Furthermore, the different stages of data acquisition and processing are associated with various degrees of uncertainty. In this review, the problems of particular relevance to absolute quantification of cerebral perfusion parameters using dynamic susceptibility contrast magnetic resonance imaging are discussed, and possible solutions are outlined. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1524000
- author
- Knutsson, Linda
LU
; Ståhlberg, Freddy
LU
and Wirestam, Ronnie
LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Magma
- volume
- 23
- pages
- 1 - 21
- publisher
- Springer
- external identifiers
-
- wos:000274299500001
- pmid:19960361
- scopus:76649106726
- ISSN
- 1352-8661
- DOI
- 10.1007/s10334-009-0190-2
- project
- Optimisation and Validation of Dynamic Susceptibility Contrast MRI
- language
- English
- LU publication?
- yes
- id
- cd0b19c7-ceba-4544-87e8-4d54d55b5c08 (old id 1524000)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19960361?dopt=Abstract
- date added to LUP
- 2016-04-04 13:51:14
- date last changed
- 2022-04-13 12:04:44
@article{cd0b19c7-ceba-4544-87e8-4d54d55b5c08,
abstract = {{Absolute quantification of cerebral blood flow, cerebral blood volume and mean transit time is desirable in the determination of tissue viability thresholds and tissue at risk in acute ischaemic stroke, as well as in cases where a global reduction in cerebral blood flow is expected, for example, in patients with dementia or depressive disorders. Absolute values are also useful when comparing sequential examinations of tissue perfusion parameters, for example, in the monitoring and follow-up of various kinds of therapy. Regardless of the method employed, a number of assumptions and approximations must be made to obtain absolute measures of perfusion. Furthermore, the different stages of data acquisition and processing are associated with various degrees of uncertainty. In this review, the problems of particular relevance to absolute quantification of cerebral perfusion parameters using dynamic susceptibility contrast magnetic resonance imaging are discussed, and possible solutions are outlined.}},
author = {{Knutsson, Linda and Ståhlberg, Freddy and Wirestam, Ronnie}},
issn = {{1352-8661}},
language = {{eng}},
pages = {{1--21}},
publisher = {{Springer}},
series = {{Magma}},
title = {{Absolute quantification of perfusion using dynamic susceptibility contrast MRI: pitfalls and possibilities.}},
url = {{http://dx.doi.org/10.1007/s10334-009-0190-2}},
doi = {{10.1007/s10334-009-0190-2}},
volume = {{23}},
year = {{2010}},
}