Prediction of postpartum diabetes in women with gestational diabetes mellitus
Ekelund, M. ; Shaat, Nael LU
; Almgren, Peter
LU
; Groop, Leif
LU
and Berntorp, Kerstin
LU
(2010)
In Diabetologia
53(3).
p.452-457
- Abstract
- We studied the incidence of postpartum diabetes after gestational diabetes mellitus and investigated biochemical and clinical predictors of postpartum diabetes. We monitored 174 women with gestational diabetes by performing oral glucose tolerance tests during pregnancy as well as 1, 2 and 5 years postpartum. Women who developed impaired fasting glucose, impaired glucose tolerance or diabetes were compared with women who remained normoglycaemic at 5 years. Insulinogenic index, disposition index and HOMA-beta cell index were used to assess beta cell function; insulin resistance was estimated by HOMA index of insulin resistance. At 5 years postpartum, 30% of the women had developed diabetes and 51% some form of abnormal glucose tolerance.... (More)
- We studied the incidence of postpartum diabetes after gestational diabetes mellitus and investigated biochemical and clinical predictors of postpartum diabetes. We monitored 174 women with gestational diabetes by performing oral glucose tolerance tests during pregnancy as well as 1, 2 and 5 years postpartum. Women who developed impaired fasting glucose, impaired glucose tolerance or diabetes were compared with women who remained normoglycaemic at 5 years. Insulinogenic index, disposition index and HOMA-beta cell index were used to assess beta cell function; insulin resistance was estimated by HOMA index of insulin resistance. At 5 years postpartum, 30% of the women had developed diabetes and 51% some form of abnormal glucose tolerance. Women who developed diabetes had higher fasting glucose and HbA(1c) during pregnancy than those who remained normoglycaemic. They also had lower HOMA-beta cell index, insulinogenic index and disposition index than the normoglycaemic women. HbA(1c) and fasting glucose during pregnancy as well as the number of previous pregnancies and family history of diabetes were independent predictors of postpartum diabetes. HbA(1c) a parts per thousand yen4.7% (Swedish Mono S) or a parts per thousand yen5.7% (National Glycohemoglobin Standardization Program) and fasting blood glucose a parts per thousand yen5.2 mmol/l were associated with a four- to sixfold increased risk. Among women with gestational diabetes mellitus, those at risk of future diabetes can be identified by HbA(1c) and fasting glucose values in the upper normal range during pregnancy. A family history of diabetes and previous pregnancies further increase this risk. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1571085
- author
- Ekelund, M.
; Shaat, Nael
LU
; Almgren, Peter
LU
; Groop, Leif
LU
and Berntorp, Kerstin
LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- resistance, Insulin, Insulinogenic index, HOMA, HbA(1c), diabetes mellitus, Gestational, GAD-antibodies, Beta cell dysfunction, Disposition index, OGTT, Postpartum diabetes
- in
- Diabetologia
- volume
- 53
- issue
- 3
- pages
- 452 - 457
- publisher
- Springer
- external identifiers
-
- wos:000274238500008
- scopus:77949275838
- ISSN
- 1432-0428
- DOI
- 10.1007/s00125-009-1621-3
- language
- English
- LU publication?
- yes
- id
- 5650f1b7-d1a7-4a95-babe-7bb6d030571b (old id 1571085)
- date added to LUP
- 2016-04-01 10:30:11
- date last changed
- 2024-04-07 11:30:34
@article{5650f1b7-d1a7-4a95-babe-7bb6d030571b,
abstract = {{We studied the incidence of postpartum diabetes after gestational diabetes mellitus and investigated biochemical and clinical predictors of postpartum diabetes. We monitored 174 women with gestational diabetes by performing oral glucose tolerance tests during pregnancy as well as 1, 2 and 5 years postpartum. Women who developed impaired fasting glucose, impaired glucose tolerance or diabetes were compared with women who remained normoglycaemic at 5 years. Insulinogenic index, disposition index and HOMA-beta cell index were used to assess beta cell function; insulin resistance was estimated by HOMA index of insulin resistance. At 5 years postpartum, 30% of the women had developed diabetes and 51% some form of abnormal glucose tolerance. Women who developed diabetes had higher fasting glucose and HbA(1c) during pregnancy than those who remained normoglycaemic. They also had lower HOMA-beta cell index, insulinogenic index and disposition index than the normoglycaemic women. HbA(1c) and fasting glucose during pregnancy as well as the number of previous pregnancies and family history of diabetes were independent predictors of postpartum diabetes. HbA(1c) a parts per thousand yen4.7% (Swedish Mono S) or a parts per thousand yen5.7% (National Glycohemoglobin Standardization Program) and fasting blood glucose a parts per thousand yen5.2 mmol/l were associated with a four- to sixfold increased risk. Among women with gestational diabetes mellitus, those at risk of future diabetes can be identified by HbA(1c) and fasting glucose values in the upper normal range during pregnancy. A family history of diabetes and previous pregnancies further increase this risk.}},
author = {{Ekelund, M. and Shaat, Nael and Almgren, Peter and Groop, Leif and Berntorp, Kerstin}},
issn = {{1432-0428}},
keywords = {{resistance; Insulin; Insulinogenic index; HOMA; HbA(1c); diabetes mellitus; Gestational; GAD-antibodies; Beta cell dysfunction; Disposition index; OGTT; Postpartum diabetes}},
language = {{eng}},
number = {{3}},
pages = {{452--457}},
publisher = {{Springer}},
series = {{Diabetologia}},
title = {{Prediction of postpartum diabetes in women with gestational diabetes mellitus}},
url = {{http://dx.doi.org/10.1007/s00125-009-1621-3}},
doi = {{10.1007/s00125-009-1621-3}},
volume = {{53}},
year = {{2010}},
}